2020
DOI: 10.3390/mi11070653
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Dielectrophoretic Microfluidic Device for Separating Microparticles Based on Size with Sub-Micron Resolution

Abstract: This article details the mathematical model of a microfluidic device aimed at separating any binary heterogeneous sample of microparticles into two homogeneous samples based on size with sub-micron resolution. The device consists of two sections, where the upstream section is dedicated to focusing of microparticles, while the downstream section is dedicated to separation of the focused stream of microparticles into two samples based on size. Each section has multiple planar electrodes of finite size protruding… Show more

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Cited by 6 publications
(3 citation statements)
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References 23 publications
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“…Numerous separation processes of colloidal particles, including cells, exploit differences in the particle size. Our group has reported the EK size-based separation of polystyrene particles in a continuous mode and also, along with cells, in a trapping mode. , Other groups have also successfully demonstrated size-based separations of cells and polystyrene particles employing EK phenomena. However, at high electric fields in systems stimulated with DC and low frequency AC potentials, nonlinear EP plays a major role in the overall migration of colloidal particles. Thus, it is essential to understand the influence of particle size on nonlinear electrophoretic effects, in particular, the effects of particle size on the mobility of the nonlinear electrophoretic velocity.…”
Section: Resultsmentioning
confidence: 96%
“…Numerous separation processes of colloidal particles, including cells, exploit differences in the particle size. Our group has reported the EK size-based separation of polystyrene particles in a continuous mode and also, along with cells, in a trapping mode. , Other groups have also successfully demonstrated size-based separations of cells and polystyrene particles employing EK phenomena. However, at high electric fields in systems stimulated with DC and low frequency AC potentials, nonlinear EP plays a major role in the overall migration of colloidal particles. Thus, it is essential to understand the influence of particle size on nonlinear electrophoretic effects, in particular, the effects of particle size on the mobility of the nonlinear electrophoretic velocity.…”
Section: Resultsmentioning
confidence: 96%
“…In this article, patterning approaches that use EFs will be referred to as “electropatterning.” The reports analyzed here include the deposition, orderly manipulation, and specific sorting of bioparticles. This review begins with simple colloidal arrangements and progresses to more complex macromolecular structures as EK properties may vary in size and structural complexity [33–36]. Although most of the compiled research studies have focused on manipulation by either electrophoresis (EP) or dielectrophoresis (DEP), some breakthroughs that combine these methods with other mechanical, optical, or magnetic forces are also included.…”
Section: Introductionmentioning
confidence: 99%
“…Even after the above-mentioned traits of these microfluidic systems and tools for manipulation of fluid flow, each system is distinct, and accordingly, each microfluidic device has its own merits and demerits [26]. Usually, microfluidic deal with mixing, transferring, separating, and processing the fluids [27][28][29]. Further, as a passive technique, inertial microfluidic-based devices manipulate particles and cells by taking the advantage of hydrodynamic forces in microchips with a diversity of cross-sections [30].…”
Section: Introductionmentioning
confidence: 99%