Dielectrophoretic separation of carbon nanotubes and polystyrene microparticles

Zhang, C.; Khoshmanesh, Khashayar; Tovar-Lopez, Francisco J.; Mitchell, Arnan; Włodarski, W.; Klantar-zadeh, K.

doi:10.1007/s10404-009-0419-4

Cited by 50 publications

(45 citation statements)

References 44 publications

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“…Electrode-based dielectrophoresis (eDEP) separators employ high-frequency AC electric voltages imposed upon in-channel microelectrodes to create electric field gradients (Choi and Park 2005;Kralj et al 2006;Chen and Du 2007;Demierre et al 2007;Kim et al 2007;Vahey and Voldman 2008;Han and Frazier 2008;Wang et al 2009;Khoshmanesh et al 2009;Zhang et al 2009;Lewpiriyawong et al 2010;Khoshmanesh et al 2010). Such active particle separations arise from the dependence of DEP on AC field frequency and particle properties.…”

Section: Introductionmentioning

confidence: 99%

Continuous-flow particle and cell separations in a serpentine microchannel via curvature-induced dielectrophoresis

Zhu

Canter

Keten

et al. 2011

Microfluid Nanofluid

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Particle and cell separations are critical to chemical and biomedical analyses. This study demonstrates a continuous-flow electrokinetic separation of particles and cells in a serpentine microchannel through curvatureinduced dielectrophoresis. The separation arises from the particle size-dependent cross-stream dielectrophoretic deflection that is generated by the inherent electric field gradients within channel turns. Through the use of a sheath flow to focus the particle mixture, we implement a continuous separation of 1 and 5 lm polystyrene particles in a serpentine microchannel under a 15 kV/m DC electric field. The effects of the applied DC voltages and the serpentine length on the separation performance are examined. The same channel is also demonstrated to separate yeast cells (range in diameter between 4 and 8 lm) from 3 lm particles under an electric field as low as 10 kV/m. The observed focusing and separation processes for particles and cells in the serpentine microchannel are reasonably predicted by a numerical model.

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Section: Introductionmentioning

confidence: 99%

Continuous-flow particle and cell separations in a serpentine microchannel via curvature-induced dielectrophoresis

Zhu

Canter

Keten

et al. 2011

Microfluid Nanofluid

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“…Amongst these phenomena, dielectrophoresis can be efficiently employed in exploiting the dielectric properties of particles within the suspension. These properties are closely relevant to particles' structures and compositions which are crucial factors for their manipulations (Gascoyne and Vykoukal 2004;Zhang et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Dielectrophoretic-activated cell sorter based on curved microelectrodes

Khoshmanesh

Zhang

Tovar-Lopez

et al. 2009

Microfluid Nanofluid

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This article presents the numerical and experimental analysis of a dielectrophoretic-activated cell sorter (DACS), which is equipped with curved microelectrodes. Curved microelectrodes offer unique advantages, since they create strong dielectrophoretic (DEP) forces over the tips and maintain it over a large portion of their structure, as predicted by simulations. The performance of the system is assessed using yeast (Saccharomyces cerevisiae) cells as model organisms. The separation of the live and dead cells is demonstrated at different medium conductivities of 0.001 and 0.14 S/m, and the sorting performance was assessed using a second array of microelectrodes patterned downstream the microchannel. Further, microscopic cell counting analysis reveals that a single pass through the system yields a separating efficiency of *80% at low medium conductivities and *85% at high medium conductivities.

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“…LOC systems bring miniaturization, parallelization, and integration to the analyses and applications in chemical, biological and clinical fields [4][5][6] . One of the crucial applications is the continuous and accurate manipulation of microparticles and nanoparticles [7][8][9][10][11][12][13][14][15] , such as bacteria [16][17][18] , protein [19][20][21] , DNA 22 , virus [23][24][25] and cells [26][27][28] .…”

Section: Introductionmentioning

confidence: 99%

Separation of nanoparticles by a nano-orifice based DC-dielectrophoresis method in a pressure-driven flow

Zhao

Peng

2016

Nanoscale

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A novel DC-Dielectrophoresis (DEP) method employing pressure-driven flow for the continuous separation of micro/nanoparticles is presented in this paper. To generate the DEP force, a small voltage difference is applied to produce the nonuniformity of the electric field across a microchannel via a larger orifice of several hundred microns on one side of the channel wall and a smaller orifice of several hundred nanometers on the opposite channel wall. The particles experience DEP force when they move with the flow through the vicinity of the small orifice, where exits the strongest electrical field gradient. Experiments were conducted to demonstrate the separation of 1 µm and 3 µm polystyrene particles by size by adjusting the applied electrical potentials. In order to separate smaller nanoparticles, the electrical conductivity of the suspending solution is adjusted so that the polystyrene nanoparticles of a given size experience positive DEP while the polystyrene nanoparticles of another size experience negative DEP. Using this method, the separation of 51 nm and 140 nm nanoparticles and the separation of 140 nm and 500 nm nanoparticles were demonstrated. In comparison with the microfluidic DC-DEP methods reported in the literatures which utilize hurdles or obstacles to induce the non-uniformity of electric field, a pair of asymmetrical orifices on the channel side walls is used in this method to generate strong electrical field gradient and has advantages such as capability of separating nanoparticles, and locally applied lower electrical voltages to minimize Joule heating effect.

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Dielectrophoretic separation of carbon nanotubes and polystyrene microparticles

Cited by 50 publications

References 44 publications

Continuous-flow particle and cell separations in a serpentine microchannel via curvature-induced dielectrophoresis

Continuous-flow particle and cell separations in a serpentine microchannel via curvature-induced dielectrophoresis

Dielectrophoretic-activated cell sorter based on curved microelectrodes

Separation of nanoparticles by a nano-orifice based DC-dielectrophoresis method in a pressure-driven flow

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