Diencephalic Seizures

Andy, O.J.; Jurko, M.

doi:10.1159/000101244

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Thalamic areas are also able to reduce epileptiform activity if they were stimulated electrically. In humans, electrical stimulation of the centromedial, anterior or reticular nuclei reduced different types of epilepsy 31,32 . In summary, our results suggest that these differences may be particularly important for understanding triggering and spreading mechanisms underlying epileptic activity during status epilepticus and recurrent seizures.…”

Section: Discussionmentioning

confidence: 99%

Glucose utilisation during status epilepticus in an epilepsy model induced by pilocarpine: a qualitative study

Arida

Priel

Calderazzo

et al. 2002

Arq. Neuro-Psiquiatr.

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-Status epilepticus (SE) is a medical emergency and it is associated to brain damage. 2-deoxy-[14 C] glucose (2-DG) procedure has been used to measure the alterations in the functional activity of the brain induced by various pharmacological and toxicological agents. The aim of this study was to determine which changes occur in the seizure anatomic substrates during the SE induced by pilocarpine (PILO) using [ 14 C]-2 deoxyglucose functional mapping technique. Wistar male adult rats were submitted to SE PILO-induced for 6h and received [ 14 C] 2-deoxyglucose injection via jugular vein 45 min before the 6 th hour of SE. The control animals were submitted to all procedures but received saline and not pilocarpine. Brain sections were prepared and exposed X-ray film about seven days. The optical density of each region was obtained using a solid state digital analyser. The analysis revealed that 14 C-2DG utilisation was pronounced in the SE rats on the areas corresponding to the hippocampal formation (+50.6%), caudate-putamen (+30.6%), frontoparietal cortex (+32.2%), amygdala (+31.7%), entorrinal cortex (+28.2%), thalamic nucleus (+93.5%), pre-tectal area (+50.1%) and substantia nigra (+50.3%) when compared to control. Our results suggest that the different activation levels of the distinct structures may be particularly important for understanding triggering and spreading mechanisms underlying epileptic activity during status epilepticus.KEY WORDS: deoxyglucose, pilocarpine, seizure, status epilepticus.Utilização de glicose durante o estado de mal epiléptico no modelo de epilepsia induzido pela pilocarpina: um estudo qualitativo RESUMO -O estado de mal epiléptico (SE) é uma emergência médica e está associado a lesão cerebral. O procedimento da [ 14 C] desoxiglicose tem sido utilizado para avaliar as alterações da atividade funcional cerebral induzidas por agentes farmacológicos e toxicológicos. O objetivo deste estudo foi verificar as alterações metabólicas do cérebro de ratos durante o SE induzido pela pilocarpina, para tanto, utilizamos a técnica de mapeamento funcional da [ 14 C] desoxiglicose. Ratos machos da raça Wistar foram submetidos ao SE induzido pela pilocarpina durante período de 6 horas; 45 minutos antes de se completar 6 horas de SE, tais animais receberam uma injeção de [ 14 C] desoxiglicose por via venosa (veia jugular). Os animais pertencentes ao grupo controle foram submetidos aos mesmos procedimentos, no entanto, receberam solução salina e não pilocarpina. As fatias cerebrais foram preparadas e expostas em filme de raioX por um período de sete dias. A análise da densidade óptica de cada região foi obtida por analisador digital de estado sólido. Tal análise revelou aumento no consumo de glicose durante o SE nas seguintes regiões: formação hipocampal (+50,6%), núcleo caudadoputamen (+30,6%), córtex frontoparietal (+32,2%), amigdala (+31,7%), córtex entorrinal (+28,2%), complexo talâmico (+93,5%), área pré-tectal (+50,1%) e substância negra (+50,3%), quando comparadas com os animais pertence...

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Section: Discussionmentioning

confidence: 99%

Glucose utilisation during status epilepticus in an epilepsy model induced by pilocarpine: a qualitative study

Arida

Priel

Calderazzo

et al. 2002

Arq. Neuro-Psiquiatr.

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“…Salvos of yawning and irrepressible hiccupping accompany this spectacular and very unpleasant profile. The cases described reveal the presence of thalamic tumors [83][84][85][86][87]. D'Mello et al [88] also reported salvos of yawns as an iatrogenic effect of vibratory massage or of the withdrawal of neuroleptics, persisting several months after convulsions are provoked.…”

Section: Excessive Yawningmentioning

confidence: 93%

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Walusinski¹

2010

The Mystery of Yawning in Physiology and Disease

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Diencephalic Seizures

Cited by 2 publications

References 8 publications

Glucose utilisation during status epilepticus in an epilepsy model induced by pilocarpine: a qualitative study

Glucose utilisation during status epilepticus in an epilepsy model induced by pilocarpine: a qualitative study

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