Diencephalic syndrome in childhood craniopharyngioma – Results of German multicentre studies on 485 long-term survivors of childhood craniopharyngioma

Hoffmann, Anika; Sterkenburg, AS; Gebhardt, Ursel; Warmuth-Metz, M.; Müller, HL

doi:10.1055/s-0035-1547676

Cited by 2 publications

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“…Surgical removal of tumor tissue beyond the mammillary bodies (i.e., in the posterior hypothalamic area) endangers hypothalamic structures and may cause hypothalamic obesity (Muller, 2011a(Muller, , 2011b. With the aid of imaging studies, several reports have indicated that the degree of obesity of affected childhood craniopharyngioma patients is positively correlated with the degree and extent of hypothalamic damage (de Vile et al, 1996a;Holmer et al, 2009Holmer et al, , 2010Muller et al, 2011b;Hoffmann et al, 2014a). Fjalldal et al recently published the results of a cross-sectional study of 42 patients who were analyzed for cognitive performance and psychosocial health at a median follow-up of 20 years (1e40 years) after diagnosis of childhood craniopharyngioma.…”

Section: Hypothalamic Dysfunctionmentioning

confidence: 99%

Craniopharyngioma – Pediatric Management

Müller

2015

Craniopharyngiomas

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Section: Hypothalamic Dysfunctionmentioning

confidence: 99%

Craniopharyngioma – Pediatric Management

Müller

2015

Craniopharyngiomas

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“…This is a significant problem in ADH insufficiency (15), which may be an initial symptom. Another aspect of pharmaceutical therapy is currently under investigation for hypothalamic obesity, a common complication of these tumors or surgery (16,17). So far, only limited success has been reported.…”

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confidence: 99%

Surgery for pediatric craniopharyngiomas: is less more?

Flitsch

Aberle

Burkhardt

2015

Journal of Pediatric Endocrinology and Metabolism

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Surgery for craniopharyngiomas, especially in childhood and adolescence, has evolved from an era of aggressive strategies - with the primary goal of gross total removal and accepting an impaired functional outcome - to a more individually tailored therapy that avoids immediate treatment-related and long-term morbidity. Modern imaging techniques and a wider understanding of hypothalamic risk factors have led to surgical strategies adapted to the localization of these inhomogenously grown pathologies. Whereas purely infradiaphragmatic as well as supradiaphragmatic/infrachiasmatic tumors have a favorably surgical outcome with higher gross total resection rates in experienced hands, lesions within the third ventricle extending beyond the mammillary bodies remain a problem. The same is valid for lesions beyond 3 cm in diameter, more or less independent of their localization. Aside from the traditional microscopic approach via the subfrontal or pterional craniotomy, transsphenoidal approaches and other minimal invasive surgical methods, e.g., catheter implantation into cystic formations of the tumor have become popular. Radiotherapy, with its risks and limitations, can effectively be added to avoid recurrences. Nowadays, surgery as part of an interdisciplinary treatment strategy is still the typical first choice. However, taking the patient's long-term prognosis into considertaion, the surgical complication rates have to be minimized.

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Diencephalic syndrome in childhood craniopharyngioma – Results of German multicentre studies on 485 long-term survivors of childhood craniopharyngioma

Cited by 2 publications

References 0 publications

Craniopharyngioma – Pediatric Management

Craniopharyngioma – Pediatric Management

Surgery for pediatric craniopharyngiomas: is less more?

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