2017
DOI: 10.1016/j.ejogrb.2017.02.015
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Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission

Abstract: Dienogest is an effective medication to control symptoms of pain related to DIE, even without reducing the volume of DIE nodules.

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Cited by 60 publications
(48 citation statements)
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“…Eight studies were case series (seven prospective, one retrospective) (10)(11)(12)(13)(14)(32)(33)(34), two were retrospective cohort studies (29,35) and four were case reports (36-39) ( Table 1). Eight studies were case series (seven prospective, one retrospective) (10)(11)(12)(13)(14)(32)(33)(34), two were retrospective cohort studies (29,35) and four were case reports (36-39) ( Table 1).…”
Section: Resultsmentioning
confidence: 99%
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“…Eight studies were case series (seven prospective, one retrospective) (10)(11)(12)(13)(14)(32)(33)(34), two were retrospective cohort studies (29,35) and four were case reports (36-39) ( Table 1). Eight studies were case series (seven prospective, one retrospective) (10)(11)(12)(13)(14)(32)(33)(34), two were retrospective cohort studies (29,35) and four were case reports (36-39) ( Table 1).…”
Section: Resultsmentioning
confidence: 99%
“…A total of 420 women with large bowel endometriosis treated with combined oral contraceptives (OC), progestins, gonadotropin releasing-hormone (GnRH) agonists, and aromatase inhibitors have been described in 14 articles published in 2000-2018. Eight studies were case series (seven prospective, one retrospective) (10)(11)(12)(13)(14)(32)(33)(34), two were retrospective cohort studies (29,35) and four were case reports (36-39) ( Table 1). The precise location of lesions has not been systematically specified, and sometimes what was exactly intended with "colorectal endometriosis" is unclear.…”
Section: Resultsmentioning
confidence: 99%
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“…61,71,411,412 This raises the question as whether hormonal therapeutics can actually modify the epigenetic aberration, resulting in a gradual reverse of fibrogenesis, especially in highly fibrotic lesions such as DE. A recent study reports that, dienogest, a synthetic progestin, is effective in alleviating symptoms but does not reduce nodular size in DE, 413 suggesting that hormonal therapeutics cannot modify the epigenetic aberration that is already in place. This would mean the necessity of taking these drugs for a long period in order to alleviate the symptoms without changing the existing epigenetic aberrations.…”
Section: Con Clus Ionsmentioning
confidence: 99%