2020
DOI: 10.21203/rs.3.rs-84809/v1
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Dienogest exerts its anti-endometriotic effect throughthe direct suppression of matrix metallopeptidases

Abstract: Background: Endometriosis, which affects up to 10% women of reproductive age, is defined by the presence of ectopic endometrial tissue outside the uterus. The current key drug of hormonal therapies for endometriosis is dienogest, which is a progestin with high specificity for the progesterone receptor. Although many findings about the anti-endometriotic effect of dienogest on endometriosis have been reported, the precise mechanisms of dienogest's anti-endometriotic effect remain unknown. Methods: To investigat… Show more

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