To reduce CO2 and pollutant emissions, automotive manufacturers tend to turn increasingly toward electrified powertrains solutions, such as Hybrid Vehicles (HEV). Model Based System Engineering (MBSE) and computational tools are useful to support the development of HEV systems. System architectures need to be investigated to find optimal solutions regarding multiple possible goals constraints (fuel consumption, CO2 emissions, etc.). In this study, a novel global optimization framework is proposed to enable an automated cooling system optimization. The methodology starts with a set of components, design rules, and system requirements to search and automatically generate all the admissible cooling system architectures. System architectures are generated by a concept of decision tree. The decision tree algorithm is coupled to a design rules database to avoid exploring solutions that do not satisfy system requirements. Hydraulic models are automatically built for each system architecture generated to optimize head losses and minimize the pump consumption. For the most interesting solutions, 3D piping geometrical data (lengths, angles, and curve radius) are automatically drawn by a 3D optimization tool. Piping geometrical data are integrated in GT-SUITE thermo-hydraulic simulation models automatically built to evaluate the most interesting cooling system architectures generated. The best candidates are identified by a multi-criteria decision-making strategy. A first case of conventional vehicle cooling system is studied. Results on the given example indicate that the difference of energy consumption on WLTC cycle between the best performing architecture and the worst one is 69%.