Diesel Exhaust Particles: Effects on Neurofunction in Female Mice

Hougaard, Karin Sørig; Saber, Anne Thoustrup; Jensen, Keld Alstrup; Vogel, Ulla; Wallin, Håkan

doi:10.1111/j.1742-7843.2009.00407.x

Cited by 22 publications

(16 citation statements)

References 20 publications

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“…In particular body size, age, gender, species, and strain are known to have dosimetric effects in air pollution research [81]. Although there is growing epidemiologic evidence that associations between air pollution and respiratory health differ between females and males, comparative studies or studies on female rodents in general are limited [72, 82]. …”

Section: Air Pollution and Neurological Diseasementioning

confidence: 99%

The Adverse Effects of Air Pollution on the Nervous System

Genç

Zadeoğluları

Fuss

et al. 2012

Journal of Toxicology

538

334

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Exposure to ambient air pollution is a serious and common public health concern associated with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air pollution on the pulmonary and cardiovascular systems have been well established in a series of major epidemiological and observational studies. In the recent past, air pollution has also been associated with diseases of the central nervous system (CNS), including stroke, Alzheimer's disease, Parkinson's disease, and neurodevelopmental disorders. It has been demonstrated that various components of air pollution, such as nanosized particles, can easily translocate to the CNS where they can activate innate immune responses. Furthermore, systemic inflammation arising from the pulmonary or cardiovascular system can affect CNS health. Despite intense studies on the health effects of ambient air pollution, the underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology. A better understanding of the mediators and mechanisms will enable the development of new strategies to protect individuals at risk and to reduce detrimental effects of air pollution on the nervous system and mental health.

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Section: Air Pollution and Neurological Diseasementioning

confidence: 99%

The Adverse Effects of Air Pollution on the Nervous System

Genç

Zadeoğluları

Fuss

et al. 2012

Journal of Toxicology

538

334

View full text Add to dashboard Cite

show abstract

“…Exposure of adult mice to DE has been reported to alter locomotor activity, spatial learning and memory, and novel object recognition ability [71–73]. Nasal instillation of nanoparticle-rich DE alters emotional behavior and learning capability in rats [74].…”

Section: Neurotoxic Effects Of Air Pollution In Animals and In Vitmentioning

confidence: 99%

Neurotoxicants Are in the Air: Convergence of Human, Animal, andIn VitroStudies on the Effects of Air Pollution on the Brain

Costa

Cole

Coburn

et al. 2014

BioMed Research International

177

121

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In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also negatively affect the brain and contribute to central nervous system diseases. Air pollution is a mixture comprised of several components, of which ultrafine particulate matter (UFPM; <100 nm) is of much concern, as these particles can enter the circulation and distribute to most organs, including the brain. A major constituent of ambient UFPM is represented by traffic-related air pollution, mostly ascribed to diesel exhaust (DE). Human epidemiological studies and controlled animal studies have shown that exposure to air pollution may lead to neurotoxicity. In addition to a variety of behavioral abnormalities, two prominent effects caused by air pollution are oxidative stress and neuroinflammation, which are seen in both humans and animals and are confirmed by in vitro studies. Among factors which can affect neurotoxic outcomes, age is considered the most relevant. Human and animal studies suggest that air pollution (and DE) may cause developmental neurotoxicity and may contribute to the etiology of neurodevelopmental disorders, including autistic spectrum disorders. In addition, air pollution exposure has been associated with increased expression of markers of neurodegenerative disease pathologies.

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“…Few studies have examined controlled acute exposure of humans to DE; for example, acute exposure of humans to DE (300 µg/m 3 ) has been shown to induce EEG changes (Cruts et al, 2008). Exposure of mice to DE has been reported to alter locomotor activity and spatial learning and memory (Yokota et al, 2009; Hougaard et al, 2009; Suzuki et al, 2010; Win-Shwe et al, 2008; 2014). Biochemical and molecular studies have evidenced that the most prominent effects of DE exposure on the CNS are oxidative stress and neuroinflammation (MohanKumar et al, 2008; Kraft and Harry, 2011; Win-Shwe and Fujimaki, 2011).…”

Section: Introductionmentioning

confidence: 99%

Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain

et al. 2016

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In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also contribute to central nervous system (CNS) diseases. Traffic-related air pollution is a major contributor to global air pollution, and diesel exhaust (DE) is its most important component. DE contains more than 40 toxic air pollutants and is a major constituent of ambient particulate matter (PM), particularly of ultrafine-PM. Limited information suggest that exposure to DE may cause oxidative stress and neuroinflammation in the CNS. We hypothesized that males may be more susceptible than females to DE neurotoxicity, because of a lower level of expression of paraoxonase 2 (PON2), an intracellular anti-oxidant and anti-inflammatory enzyme. Acute exposure of C57BL/6 mice to DE (250–300 µg/m3 for 6h) caused significant increases in lipid peroxidation and of pro-inflammatory cytokines (IL-1α, IL-1β, IL-3, IL-6, TNF-α) in various brain regions (particularly olfactory bulb and hippocampus). In a number of cases the observed effects were more pronounced in male than in female mice. DE exposure also caused microglia activation, as measured by increased Iba1 (ionized calcium-binding adapter molecule 1) expression, and of TSPO (translocator protein) binding. Mice heterozygotes for the modifier subunit of glutamate cysteine ligase (the limiting enzyme in glutathione biosynthesis; Gclm+/− mice) appeared to be significantly more susceptible to DE-induced neuroinflammation than wild type mice. These findings indicate that acute exposure to DE causes neuroinflammation and oxidative stress in brain, and suggests that sex and genetic background may play important roles in modulating susceptibility to DE neurotoxicity.

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Diesel Exhaust Particles: Effects on Neurofunction in Female Mice

Cited by 22 publications

References 20 publications

The Adverse Effects of Air Pollution on the Nervous System

The Adverse Effects of Air Pollution on the Nervous System

Neurotoxicants Are in the Air: Convergence of Human, Animal, andIn VitroStudies on the Effects of Air Pollution on the Brain

Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain

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