Diet and functional dyspepsia: Clinical correlates and therapeutic perspectives

Pesce, Marcella; Cargiolli, Martina; Cassarano, Sara; Polese, Barbara; Conno, Barbara De; Aurino, Laura; Mancino, Nicola; Sarnelli, Giovanni

doi:10.3748/wjg.v26.i5.456

Cited by 43 publications

(35 citation statements)

References 61 publications

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“…Complementary and alternative treatments have been reported as beneficial in treating FD symptoms [ 27 ], and may thereby enhance the effectiveness of dietary management strategies. Four trials have reported that supplements containing peppermint and caraway oil were more effective than placebo in improving dyspeptic symptoms, with an average decreased intensity of epigastric pain compared to placebo [ 4 , 111 , 112 , 113 ]. In mechanistic studies, the active components of these oils were reported to have antiemetic, choleretic and spasmolytic effects in the distal stomach and duodenal bulb [ 112 ].…”

Section: Complementary Therapies and Micronutrient Supplementation In Dietary Management Of Fdmentioning

confidence: 99%

“…Four trials have reported that supplements containing peppermint and caraway oil were more effective than placebo in improving dyspeptic symptoms, with an average decreased intensity of epigastric pain compared to placebo [ 4 , 111 , 112 , 113 ]. In mechanistic studies, the active components of these oils were reported to have antiemetic, choleretic and spasmolytic effects in the distal stomach and duodenal bulb [ 112 ]. The anti-inflammatory, antiemetic and motility-related properties of polyphenols in ginger enhance gastric emptying, improve gastric motility, reduce nausea and vomiting and reduce inflammation [ 112 ].…”

Section: Complementary Therapies and Micronutrient Supplementation In Dietary Management Of Fdmentioning

confidence: 99%

“…In mechanistic studies, the active components of these oils were reported to have antiemetic, choleretic and spasmolytic effects in the distal stomach and duodenal bulb [ 112 ]. The anti-inflammatory, antiemetic and motility-related properties of polyphenols in ginger enhance gastric emptying, improve gastric motility, reduce nausea and vomiting and reduce inflammation [ 112 ]. Iberogast (STW5) contains a combination of nine herbs and appears to reduce FD symptoms by enhancing antral motility and proximal gastric relaxation [ 38 ].…”

Section: Complementary Therapies and Micronutrient Supplementation In Dietary Management Of Fdmentioning

confidence: 99%

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Mechanisms of Food-Induced Symptom Induction and Dietary Management in Functional Dyspepsia

et al. 2021

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Functional dyspepsia (FD) is a common disorder of gut-brain interaction, characterised by upper gastrointestinal symptom profiles that differentiate FD from the irritable bowel syndrome (IBS), although the two conditions often co-exist. Despite food and eating being implicated in FD symptom induction, evidence-based guidance for dietetic management of FD is limited. The aim of this narrative review is to collate the possible mechanisms for eating-induced and food-related symptoms of FD for stratification of dietetic management. Specific carbohydrates, proteins and fats, or foods high in these macronutrients have all been reported as influencing FD symptom induction, with removal of ‘trigger’ foods or nutrients shown to alleviate symptoms. Food additives and natural food chemicals have also been implicated, but there is a lack of convincing evidence. Emerging evidence suggests the gastrointestinal microbiota is the primary interface between food and symptom induction in FD, and is therefore a research direction that warrants substantial attention. Objective markers of FD, along with more sensitive and specific dietary assessment tools will contribute to progressing towards evidence-based dietetic management of FD.

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Section: Complementary Therapies and Micronutrient Supplementation In Dietary Management Of Fdmentioning

confidence: 99%

Section: Complementary Therapies and Micronutrient Supplementation In Dietary Management Of Fdmentioning

confidence: 99%

Section: Complementary Therapies and Micronutrient Supplementation In Dietary Management Of Fdmentioning

confidence: 99%

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Mechanisms of Food-Induced Symptom Induction and Dietary Management in Functional Dyspepsia

et al. 2021

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“…Even if there is no standardized approach to the dietary management of functional dyspepsia, current dietary suggestions focus on eating more frequent and smaller meals, based on the evidence that a high meal volume and gastric distension could be implicated in triggering symptoms, and on "low-fat" diets [111]. It has been demonstrated that fats could exacerbate the symptoms of dyspepsia through delayed gastric emptying and hypersensitivity to gastrointestinal hormones [112].…”

Section: Functional Dyspepsiamentioning

confidence: 99%

Diet and Nutrients in Gastrointestinal Chronic Diseases

et al. 2020

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Diet and nutrition are known to play key roles in many chronic gastrointestinal diseases, regarding both pathogenesis and therapeutic possibilities. A strong correlation between symptomatology, disease activity and eating habits has been observed in many common diseases, both organic and functional, such as inflammatory bowel disease and irritable bowel syndrome. New different dietary approaches have been evaluated in order improve patients’ symptoms, modulating the type of sugars ingested, the daily amount of fats or the kind of metabolites produced in gut. Even if many clinical studies have been conducted to fully understand the impact of nutrition on the progression of disease, more studies are needed to test the most promising approaches for different diseases, in order to define useful guidelines for patients.

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“…In functional dyspepsia, acid suppressive therapy, Helicobacter pylori eradication, prokinetic agents, and neuromodulators can be applied [33]. No standardized nutritional guidelines for functional dyspepsia are available presumably due to the heterogeneous nature of functional dyspepsia [34].…”

Section: Literature Reviewmentioning

confidence: 99%

Dietary modifications achieved successful resolution of symptoms of gastroparesis diagnosed by demonstrating gastric food retention after overnight fasting in diabetic dialysis patients: two case reports with literature review

Eguchi¹

2020

Ren Replace Ther

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Background Gastroparesis is frequently overlooked and difficult to treat. The diagnosis of gastroparesis requires standard upper gastrointestinal endoscopy to exclude gastric outlet obstruction and objective evidence demonstrating delayed gastric emptying. However, none of the internationally recommended methods for measuring gastric emptying including scintigraphy are covered by the Japanese health insurance system. Limitations in the diagnosis might be related to the disease being overlooked in Japan. Meanwhile, presence of retained food in the stomach after overnight fasting without obstruction is classically known to be suggestive of gastroparesis. Some recent reports have considered gastric food retention after an overnight fasting equivalent to delayed gastric emptying. Case presentation Two diabetic dialysis patients presented with nausea, vomiting, and oral feeding intolerance in the absence of mechanical obstruction. Abdominal computed tomography, upper gastrointestinal endoscopy, and ultrasonography demonstrated gastric food retention after overnight fasting. The findings led to the diagnosis of gastroparesis. Appropriate dietary modifications alone successfully relieved the symptoms despite persistent delayed gastric emptying. Conclusions Demonstrating retained food residue after fasting for sufficient duration might be a diagnostic alternative. Dietary modifications alone provided significant clinical benefits. Possible approaches for the diagnosis and treatment of gastroparesis in Japan should be investigated.

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Diet and functional dyspepsia: Clinical correlates and therapeutic perspectives

Cited by 43 publications

References 61 publications

Mechanisms of Food-Induced Symptom Induction and Dietary Management in Functional Dyspepsia

Mechanisms of Food-Induced Symptom Induction and Dietary Management in Functional Dyspepsia

Diet and Nutrients in Gastrointestinal Chronic Diseases

Dietary modifications achieved successful resolution of symptoms of gastroparesis diagnosed by demonstrating gastric food retention after overnight fasting in diabetic dialysis patients: two case reports with literature review

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