Diet and growth during the weaning period in 3 communities in developing countries

Gärtner, Andrea; Kb, Simondon; Berger, J.; Cornu, Agnès; Simondon, François; Massamba, JP; Miguel, JL San; Ly, Cheikh; Maire, Bernard; Delpeuch, Francis

doi:10.1051/rnd:19950510

Cited by 1 publication

(2 citation statements)

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“…1. Similar to previous reports [20,21], the present study also showed that CR mice maintain a significantly higher percentage of CD4 + and CD8 + splenocytes (15 and 35% respectively), compared to AL mice. Further, CR also significantly decreased CD19 + splenocytes (22%).…”

Section: Resultssupporting

confidence: 92%

“…Fas‐ligand (Fas‐L), expressed predominantly on activated T lymphocytes [18], mediates cell death by cross‐linking to the Fas receptor [18,19]. Earlier studies, including our own, showed that CR modulates lymphocyte subsets and increases apoptosis [20,21]. Involvement of Fas and Fas‐L in both peripheral lymphoid cell death and lymphoid organ development is well‐established [22].…”

Section: Introductionmentioning

confidence: 98%

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Calorie restriction increases Fas/Fas‐ligand expression and apoptosis in murine splenic lymphocytes

1999

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One-month-old male ICR mice were fed a nutritionally adequate, semipurified diet, either ad libitum (AL) or calorie restricted (CR) (40% less food) for 6 months and were killed to obtain spleens. Flow cytometric analysis revealed increased proportions of both CD4+ and CD8+ T cells in CR-fed mice compared to AL-fed mice. The T cell subsets of CR-fed mice were also found to have higher levels of plasma membrane Fas receptor expression. Similarly, Fas-ligand (Fas-L) expression was higher in anti-CD3-stimulated CD4+ and CD8+ T cells. CR-fed mice also had increased numbers of annexin V-positive CD4+ and CD8+ T cells in stimulated splenic lymphocytes suggesting an increased potential for apoptosis. Fas and Fas-L gene expression in splenic lymphocytes, which correlated closely with the observed increased rate of apoptosis, was significantly increased in CR-fed mice compared to AL-fed mice. In conclusion, these results indicate that CR increases the expression of Fas and Fas-L which may contribute to the known beneficial effects of CR such as prolongation of life span by activating chronic physiologically mediated apoptosis.

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Section: Resultssupporting

confidence: 92%