Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon

Jin, Yang; Harvey, Thomas Nelson; Bartošová, Zdeňka; Hassani, Sahar; Bruheim, Per; Sandve, Simen Rød; Vik, Jon Olav

doi:10.1021/acs.jafc.0c07281

Cited by 10 publications

(12 citation statements)

References 58 publications

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“…Some studies carried out on fish show that the esterification of fatty acids in the sn-1/2 positions varies depending on the species and living conditions, observing that the abundance of phospholipids in the muscle of Salmo salar was lower in fish reared in seawater compared to freshwater fish, except PC and PE 44:12, which were present in greater abundance in the latter group [ 21 ], which is consistent with the results of this study. Additionally, Song et al [ 16 ] determined by REIMS (negative scan mode) that the main n-7 lipid species detected in Salmo salar fillet correspond to phospholipids such as PC 16:1-18:1, PC 16:1-20: 2, PE 16:1-18:1 and PE 16:1-18:0, unlike those of other species, such as tuna, butterfish and shrimp, among other organisms.…”

Section: Resultssupporting

confidence: 91%

“…Likewise, a recent study determined the effect of the inclusion of palm and flaxseed oil in seawater and freshwater conditions in the diet on lipidome remodeling (UPC2-MS/MS, positive-mode scanning) of Salmo salar (200 g in weight) muscle, showing that the main lipids present in this species correspond to triacylglycerols, phosphatidylcholine and phosphatidylethanolamine. It was observed that seawater allows for more active lipidome remodeling than freshwater-reared fish, mainly due to the more active lipid metabolism in the smoltification process [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

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Analysis of Muscle Lipidome in Juvenile Rainbow Trout Fed Rapeseed Oil and Cochayuyo Meal

et al. 2022

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This study aimed to analyze the effects on the lipidome of juvenile Oncorhynchus mykiss muscle fed 90% Brassica napus “rapeseed” oil and different amounts of Durvillaea antarctica “Cochayuyo” meal (1.5, 3 and 6%) as a replacement for cellulose. The analysis allowed for the identification of 329 lipids, mainly represented by phospholipids and fatty esters. The inclusion of Brassica napus oil significantly increased the levels of C18:2 species and fatty esters of hydroxylated fatty acids, which could play a bioactive role in human health. One of the most abundant lipids in all fillets was Phosphatidylcholine 33:6, which, according to the literature, could be considered a biomarker for the identification of Oncorhynchus mykiss. In all experimental diets, the species Phosphatidylethanolamine 15:1-18:24 showed four-fold higher levels than the control; increments of n-3- and n-6-rich phospholipids were also observed. Diets containing Durvillaea antarctica meal did not generate more significant variation in fish muscle phospholipids relative to the muscle of the rapeseed-oil-only group. These lipid species consist of medium- and long-chain fatty acids with different degrees of unsaturation. Still, it appears that the rapeseed oil masks the lipid contribution of the meal, possibly due to the low levels of total lipids in the macroalgae.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Analysis of Muscle Lipidome in Juvenile Rainbow Trout Fed Rapeseed Oil and Cochayuyo Meal

et al. 2022

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“…On fish so far, few lipidome data are available in relation to crosstalk between organs, maybe due to a key fat storage in liver in some species, or only the existence of white fat adipose tissue, whereas in mammals, brown adipose tissue is involved as well ( 175 , 176 ). To our knowledge, lipidome reports rather appeared in relation to fish environment or diet, focusing more on lipid metabolism than on lipokines ( 177 , 178 ). For instance, Dreier et al.…”

Section: Lipokinesmentioning

confidence: 99%

Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

et al. 2023

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Control of tissue metabolism and growth involves interactions between organs, tissues, and cell types, mediated by cytokines or direct communication through cellular exchanges. Indeed, over the past decades, many peptides produced by adipose tissue, skeletal muscle and bone named adipokines, myokines and osteokines respectively, have been identified in mammals playing key roles in organ/tissue development and function. Some of them are released into the circulation acting as classical hormones, but they can also act locally showing autocrine/paracrine effects. In recent years, some of these cytokines have been identified in fish models of biomedical or agronomic interest. In this review, we will present their state of the art focusing on local actions and inter-tissue effects. Adipokines reported in fish adipocytes include adiponectin and leptin among others. We will focus on their structure characteristics, gene expression, receptors, and effects, in the adipose tissue itself, mainly regulating cell differentiation and metabolism, but in muscle and bone as target tissues too. Moreover, lipid metabolites, named lipokines, can also act as signaling molecules regulating metabolic homeostasis. Regarding myokines, the best documented in fish are myostatin and the insulin-like growth factors. This review summarizes their characteristics at a molecular level, and describes both, autocrine effects and interactions with adipose tissue and bone. Nonetheless, our understanding of the functions and mechanisms of action of many of these cytokines is still largely incomplete in fish, especially concerning osteokines (i.e., osteocalcin), whose potential cross talking roles remain to be elucidated. Furthermore, by using selective breeding or genetic tools, the formation of a specific tissue can be altered, highlighting the consequences on other tissues, and allowing the identification of communication signals. The specific effects of identified cytokines validated through in vitro models or in vivo trials will be described. Moreover, future scientific fronts (i.e., exosomes) and tools (i.e., co-cultures, organoids) for a better understanding of inter-organ crosstalk in fish will also be presented. As a final consideration, further identification of molecules involved in inter-tissue communication will open new avenues of knowledge in the control of fish homeostasis, as well as possible strategies to be applied in aquaculture or biomedicine.

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“…162 The identification of lipid metabolites and the assessment of the variation in their composition have been explored using LC-MS in order to comprehend lipid metabolic changes occurring in fish as a response to factors that break the homeostasis of an organism, such as alterations in temperature, diet and life-stages. 157,165 The lipidome analysis of skeletal muscle from obscure pufferfish (Takifugu fasciatus) demonstrated that PL metabolites increased under cold stress through activation of the MAPK pathway. 157 A comparative study using Atlantic salmon in freshwater and seawater life-stages showed a different dynamic remodelling of the lipid class composition of gut, liver and muscle tissues when fish trailed a change in its diet (fish oil vs. vegetable oil).…”

Section: Lipidomics Of Marine Vertebratesmentioning

confidence: 99%

“…157 A comparative study using Atlantic salmon in freshwater and seawater life-stages showed a different dynamic remodelling of the lipid class composition of gut, liver and muscle tissues when fish trailed a change in its diet (fish oil vs. vegetable oil). 165 DI-MS approaches also provided significant information to elucidate the effects of diet and genetic background on TG and PL metabolism in Atlantic salmon muscle tissue. 160,161 Marine mammals have recently been the subject of some lipidomic studies, which were focused on the cetacean family (whales, dolphins and porpoises).…”

Section: Lipidomics Of Marine Vertebratesmentioning

confidence: 99%

Applications of lipidomics in marine organisms: progress, challenges and future perspectives

et al. 2022

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Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon

Cited by 10 publications

References 58 publications

Analysis of Muscle Lipidome in Juvenile Rainbow Trout Fed Rapeseed Oil and Cochayuyo Meal

Analysis of Muscle Lipidome in Juvenile Rainbow Trout Fed Rapeseed Oil and Cochayuyo Meal

Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

Applications of lipidomics in marine organisms: progress, challenges and future perspectives

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