Diet and Maternal Obesity Are Associated with Increased Oxidative Stress in Newborns: A Cross-Sectional Study

Blanco, Arturo Lopez-Yañez; Díaz-López, Keyla M; Vilchis-Gil, Jenny; Díaz-García, Héctor; Gomez-Lopez, Jacqueline; Medina-Bravo, Patricia; Granados-Riverón, Javier T.; Gallardo, Juan Manuel; Klünder-Klünder, Miguel; Sánchez-Urbina, Rocío

doi:10.3390/nu14040746

Cited by 16 publications

(19 citation statements)

References 34 publications

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“…We observed that the 8-OHdG levels in mothers and newborns correlated strongly ( Figure 2 ), which is in accordance with our previous study of another OS marker [ 39 ]. The source of 8-OHdG in pregnant women and newborns has not been identified yet [ 52 ], but Fukushima et al showed that placental tissue stained positive for 8-OHdG [ 53 ].…”

Section: Discussionsupporting

confidence: 92%

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Dietary and Antioxidant Vitamins Limit the DNA Damage Mediated by Oxidative Stress in the Mother–Newborn Binomial

Díaz-García

Vilchis-Gil

García-Roca

et al. 2022

Life

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During pregnancy, appropriate nutritional support is necessary for the development of the foetus. Maternal nutrition might protect the foetus from toxic agents such as free radicals due to its antioxidant content. In this study, 90 mothers and their children were recruited. DNA damage mediated by oxidative stress (OS) was determined by the levels of 8-hidroxy-2′-deoxyguanosine (8-OHdG) in the plasma of women and umbilical cord blood. The mothers and newborns were categorised into tertiles according to their 8-OHdG levels for further comparison. No relevant clinical differences were observed in each group. A strong correlation was observed in the mother–newborn binomial for 8-OHdG levels (Rho = 0.694, p < 0.001). In the binomial, a lower level of 8-OHdG was associated with higher consumption of calories, carbohydrates, lipids, and vitamin A (p < 0.05). In addition, the levels of 8-OHdG were only significantly lower in newborns from mothers with a higher consumption of vitamin A and E (p < 0.01). These findings were confirmed by a significant negative correlation between the 8-OHdG levels of newborns and the maternal consumption of vitamins A and E, but not C (Rho = −0.445 (p < 0.001), −0.281 (p = 0.007), and −0.120 (p = 0.257), respectively). Multiple regression analysis showed that the 8-OHdG levels in mothers and newborns inversely correlated with vitamin A (β = −1.26 (p = 0.016) and −2.17 (p < 0.001), respectively) and pregestational body mass index (β = −1.04 (p = 0.007) and −0.977 (p = 0.008), respectively). In conclusion, maternal consumption of vitamins A and E, but not C, might protect newborns from DNA damage mediated by OS.

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Section: Discussionsupporting

confidence: 92%

“…A food frequency questionnaire to assess regular food intake was administered by a trained doctor to all participants in the third trimester before labour, as previously described [ 39 ]. The questionnaire was validated for estimated folate intake in the Mexican population.…”

Section: Methodsmentioning

confidence: 99%

Dietary and Antioxidant Vitamins Limit the DNA Damage Mediated by Oxidative Stress in the Mother–Newborn Binomial

Díaz-García

Vilchis-Gil

García-Roca

et al. 2022

Life

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“…In a recent cross‐sectional study involving 242 mother‐newborn pairs, levels of oxidative stress markers (malondialdehyde and nitric oxide) in plasma from cord blood at birth were higher in mother‐newborn pairs with maternal obesity than those with normal weight. Meaningfully, a higher intake of fruit and vegetables during pregnancy was negatively correlated with the levels of oxidative stress markers 136 . Consistently, another study in nonhuman primates also reported that maternal WSD induces oxidative stress in hepatic stellate cells and myofibroblasts of fetuses 44 .…”

Section: Other Mechanisms Involved In Maternal Obesity and Offspring ...mentioning

confidence: 55%

“…Meaningfully, a higher intake of fruit and vegetables during pregnancy was negatively correlated with the levels of oxidative stress markers. 136 Consistently, another study in nonhuman primates also reported that maternal WSD induces oxidative stress in hepatic stellate cells and myofibroblasts of fetuses. 44 Alleviation of oxidative stress in the fetal livers holds the promise for halting hepatic steatosis and fibrosis via supplementation of resveratrol in WSD.…”

Section: Oxidative Stressmentioning

confidence: 59%

Maternal obesity and offspring health: Adapting metabolic changes through autophagy and mitophagy

et al. 2023

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Summary Maternal obesity leads to obstetric complications and a high prevalence of metabolic anomalies in the offspring. Among various contributing factors for maternal obesity‐evoked health sequelae, developmental programming is considered as one of the leading culprit factors for maternal obesity‐associated chronic comorbidities. Although a unified theory is still lacking to systematically address multiple unfavorable postnatal health sequelae, a cadre of etiological machineries have been put forward, including lipotoxicity, inflammation, oxidative stress, autophagy/mitophagy defect, and cell death. Hereinto, autophagy and mitophagy play an essential housekeeping role in the clearance of long‐lived, damaged, and unnecessary cell components to maintain and restore cellular homeostasis. Defective autophagy/mitophagy has been reported in maternal obesity and negatively impacts fetal development and postnatal health. This review will provide an update on metabolic disorders in fetal development and postnatal health issues evoked by maternal obesity and/or intrauterine overnutrition and discuss the possible contribution of autophagy/mitophagy in metabolic diseases. Moreover, relevant mechanisms and potential therapeutic strategies will be discussed in an effort to target autophagy/mitophagy and metabolic disturbances in maternal obesity.

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“…Fiber has usually been associated with beneficial outcomes in pregnancy. The studies by López-Yáñez [ 67 ] and Kim [ 68 ] found that pregnant women with MDA concentrations in the highest tertiles had a lower consumption of high-fiber foods, such as fruits and vegetables, than those in the lowest tertile. The Australian Longitudinal Study for Women’s Health showed that women in the highest quartile of pre-pregnancy fiber intake had a 33% lower risk of GDM compared to women in the lowest quartile.…”

Section: Discussionmentioning

confidence: 99%

Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers

et al. 2022

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Ultra-processed food (UPF) consumption during gestation may lead to increased oxidative stress (OS) and could affect pregnancy outcomes. This study aims to evaluate the association of UPF consumption during pregnancy with circulating levels of OS markers. Diet was assessed (average of three assessments) in 119 pregnant women enrolled in the OBESO perinatal cohort (Mexico), obtaining quantitative data and the percentage of energy that UPFs (NOVA) contributed to the total diet. Sociodemographic, clinical (pregestational body-mass index and gestational weight gain) and lifestyle data were collected. Maternal circulating levels of OS markers (malondialdehyde (MDA), protein carbonylation (PC), and total antioxidant capacity (TAC)) were determined at the third trimester of pregnancy. Adjusted linear regression models were performed to analyze the association between UPFs and OS markers. UPFs represented 27.99% of the total energy intake. Women with a lower UPF consumption (<75 percentile°) presented a higher intake of fiber, ω-3, ω-6, and a lower ω-6/3 ratio. Linear regression models showed that UPFs were inversely associated with TAC and MDA. Fiber intake was associated with PC. UPF intake during pregnancy may result in an increase in oxidative stress. When providing nutrition care, limiting or avoiding UPFs may be an intervention strategy that could promote a better antioxidant capacity in the body.

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Diet and Maternal Obesity Are Associated with Increased Oxidative Stress in Newborns: A Cross-Sectional Study

Cited by 16 publications

References 34 publications

Dietary and Antioxidant Vitamins Limit the DNA Damage Mediated by Oxidative Stress in the Mother–Newborn Binomial

Dietary and Antioxidant Vitamins Limit the DNA Damage Mediated by Oxidative Stress in the Mother–Newborn Binomial

Maternal obesity and offspring health: Adapting metabolic changes through autophagy and mitophagy

Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers

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