Diet and Microbes in the Pathogenesis of Lupus

Luo, Xin; Edwards, Michael; Reilly, Christopher M.; Mu, Qinghui; Ahmed, S. Ansar

doi:10.5772/68110

Cited by 2 publications

(1 citation statement)

References 179 publications

(228 reference statements)

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“…Phytoestrogens are estrogen-like substances of plant origin and can produce either good or bad effects on the development of SLE, depending on the estrogen receptor they affect [ 44 ]. Proinflammatory effect is associated with increased estrogen receptor alpha (ER α ) in lupus-prone models [ 45 ]. The difference in fiber sources between the 2018 diet with RD diet and 7013 diets is thought to be the cause of the difference in the abundance of Lachnospiraceae , where the 2018 diet used a mixture of soluble and insoluble fiber derived from plants.…”

Section: Discussionmentioning

confidence: 99%

The Role of Diet in Influencing the Diversity of Gut Microbiome Related to Lupus Disease Activities: A Systematic Review

Putri

Hamijoyo

Sahiratmadja

2022

International Journal of Microbiology

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Gut microbiome dysbiosis can affect the host immune system. The balance and activity of the gut microbiome, which are influenced by daily diet, might be associated with disease activity in systemic lupus erythematosus (SLE). Therefore, we conducted a systematic review based on the PRISMA guideline to explore the role and types of diet that affects the gut microbiome related to changes in SLE disease activity. All original and full-text English articles in the last ten years were included using predefined keywords according to PEO (population, exposure, and outcome) design in PubMed. The study subjects were carefully analyzed, including lupus-susceptible mice and humans with SLE on various diets. Children and pregnant women populations were excluded. Of 134 studies found, only seven full-text articles had met the inclusion criteria of which only one study conducted in human. This human study showed that dietary polyphenol as dihydrochalcones and flavanones affected the gut microbiome and ameliorated lupus disease activity. On the contrary, dietary flavones increased Blautia (family: Lachnospiraceae), and that often found in active lupus diseases. Furthermore, six studies in lupus-prone mice models showed that resistant starch (RS), retinoic acid (RA) or all-trans retinoic acid (tRA), and acidic water (AW) had influenced the gut microbiome, leading to an improved lupus development. Conversely, the 2018 commercial rodent diet, vitamin A-retinoic acid (VARA), neutral water (NW), and high tryptophan diet had impacted various microbiomes, resulting in increased lupus activity. Interestingly, several diets have the effect of either increasing or decreasing lupus disease activity depending on the microbiome they affect, such as AW associated with Turicibacter spp., which is frequently found in active lupus disease, and tRA in Bacteroidetes associated with renal pathology. To conclude, diet can influence the gut microbiome, which is related to the disease activity process of SLE.

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Section: Discussionmentioning

confidence: 99%

The Role of Diet in Influencing the Diversity of Gut Microbiome Related to Lupus Disease Activities: A Systematic Review

Putri

Hamijoyo

Sahiratmadja

2022

International Journal of Microbiology

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Advances in Microbiome Detection Technologies and Application in Antirheumatic Drug Design

Chen²,

Lyu³

et al. 2021

CPD

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: Rheumatic diseases are a kind of chronic inflammatory and autoimmune disease affecting the connection or supporting structures of the human body, such as the most common diseases Ankylosing spondylitis (AS), gout and Systemic lupus erythematosus (SLE). Although the precise etiology and pathogenesis of the different types of rheumatic diseases remain mostly unknown, it is now commonly believed that these diseases are attributed to some complex interactions between genetics and environmental factors, especially the gut microbiome. Altered microbiome showed clinical improvement in disease symptoms and partially restored to normality after prescribing disease-modifying antirheumatic drugs (DMARDs) or other treatment strategies. Recent advances in next-generation sequencing-based microbial profiling technology, especially metagenomics, have identified alteration of the composition and function of the gut microbiota in patients. Clinical and experimental data suggest dysbiosis may play a pivotal role in the pathogenesis of these diseases. In this paper, we provide a brief review of the advances in the microbial profiling technology and up-todate resources for accurate taxonomic assignment of metagenomic reads, which is a key step for metagenomics studies. In addition, we review the altered gut microbiota signatures that have been reported so far across various studies, upon which diagnostics classification models can be constructed, and the drug-induced regulation of the host microbiota can be used to control disease progression and symptoms.

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Diet and Microbes in the Pathogenesis of Lupus

Cited by 2 publications

References 179 publications

The Role of Diet in Influencing the Diversity of Gut Microbiome Related to Lupus Disease Activities: A Systematic Review

The Role of Diet in Influencing the Diversity of Gut Microbiome Related to Lupus Disease Activities: A Systematic Review

Advances in Microbiome Detection Technologies and Application in Antirheumatic Drug Design

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