Diet and organochlorine contaminants in women of reproductive age under 40 years old

Campoy, Cristina; Olea‐Serrano, F.; Jiménez, M. Consuelo; Cañabate, F.; Rosales, María J.; Blanca, E.; Olea, Nicolás

doi:10.1016/s0378-3782(01)00220-1

Cited by 17 publications

(5 citation statements)

References 37 publications

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“…The major reason for drug investigation in human milk is to calculate excretion of certain compounds in this fluid and, consequently, the approximate dose ingested by breastfeeding infants 1, 2. This information is important not only to protect nursing infants from undesired effects of the maternal consumption of any licit or illicit drug, but also to allow effective pharmacological treatment of breastfeeding mothers 3…”

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confidence: 99%

Liquid chromatography/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk

Pellegrini

Marchei

Rossi

et al. 2007

Rapid Comm Mass Spectrometry

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A procedure based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) is described for the determination of nicotine and its principal metabolites cotinine, trans-3-hydroxycotinine and cotinine-N-oxide, caffeine and arecoline in breast milk, using N-ethylnorcotinine as internal standard. Liquid/liquid extraction with chloroform/isopropanol (95:5, v/v) was used for nicotine, cotinine, trans-3-hydroxycotinine, cotinine-N-oxide and caffeine under neutral conditions and for arecoline under basic conditions. Chromatography was performed on a C(8) reversed-phase column using a gradient of 50 mM ammonium formate, pH 5.0, and acetonitrile as a mobile phase at a flow rate of 0.5 mL/min. Separated analytes were determined by electrospray ionization tandem mass spectrometry in the positive ion mode using multiple reaction monitoring. Limits of quantification were 5 microg/L for nicotine, cotinine, trans-3-hydroxycotinine, cotinine-N-oxide and caffeine, and 50 microg/L for arecoline using 1 mL human milk per assay. Calibration curves were linear over the calibration ranges for all the substances under investigation, with a minimum r(2) > 0.998. At three concentrations spanning the linear dynamic range of the assay, mean recoveries from breast milk ranged between 71.8 and 77.4% for different analytes. This method was applied to the analysis of analytes in human milk to assess substance exposure in breast-fed infants in relation to eventual clinical outcomes. This LC/MS/MS assay provides adequate sensitivity and performance characteristics for the simultaneous quantification of biomarkers of three of the drugs most commonly used worldwide (tobacco, caffeine and areca nut).

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confidence: 99%

Liquid chromatography/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk

Pellegrini

Marchei

Rossi

et al. 2007

Rapid Comm Mass Spectrometry

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“…As for fish, only saurel positively correlated with breast milk level of Co‐PCBs and the total of PCDD/Fs and Co‐PCBs, and salt codfish negatively correlated with the total of PCDD/Fs and Co‐PCBs. The results are not in accord with other similar studies 20–23 .…”

Section: Discussionmentioning

confidence: 99%

Associations between dietary intake and breast milk dioxin levels in Tokyo, Japan

Guan

Tajimi

Uehara

et al. 2005

Pediatrics International

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“…Similar weak and non-significant correlations between human milk BDEs and fish diet were identified. [35][36][37] Poor connections may be explained by differences in how people absorb and metabolize the contaminants. The absence of a correlation could also be due to the fact that PBDEs can come from a variety of different places, including other foods and both indoor and outdoor exposure.…”

Section: Methodsmentioning

confidence: 99%

Levels and profiles of pentabromodiphenyl ether contaminants in human breast milk from Riyadh, Saudi Arabia

Yakout

Isa

El-Sayed

et al. 2023

SMJ

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Objectives: To investigate levels of pentabromodiphenyl ether )PBDEs( in breast milk samples from healthy mothers who had lived in Riyadh for the last 5 years. Methods:In this cross sectional study, 75 samples were collected and were extracted, cleaned by solid-phase extraction )SPE( and PBDEs analysis was done using gas chromatography-mass spectrometry.Results: Total PBDEs )∑PBDEs( ranged from 0.2 to 3.6 ng/g lipid weight )lw(. were the dominant congeners. The mothers in this study consumed more meat )69%(, followed by the egg )50%(, and milk )36%(. The majority of donors consumed fish )44%( and egg )33%( 2 times per week. The majority of the participating mothers had completed higher Original Article education )68%(. All PBDE congeners were detected in the human breast milk samples with high detection frequency )98%(. The dominant congener was BDE 47, accounting more than 39% of all BDE congeners, followed by BDE-99 and BDEs 153 which accounted for18% and 12% of the total BDE congeners respectively. Conclusion:Higher rates of meat and poultry consumption were positively associated with higher breast milk levels of ∑PBDEs. The significant levels of PBDEs that occur in the meat and poultry reared in Saudi Arabia need further investigation especially as Saudis among largest consumers of poultry meat.

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Diet and organochlorine contaminants in women of reproductive age under 40 years old

Cited by 17 publications

References 37 publications

Liquid chromatography/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk

Liquid chromatography/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk

Associations between dietary intake and breast milk dioxin levels in Tokyo, Japan

Levels and profiles of pentabromodiphenyl ether contaminants in human breast milk from Riyadh, Saudi Arabia

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