Diet and Probucol in Lowering Cholesterol Concentrations

LeLorier, Jacques; Dubreuil-Quidoz, S; Lussier‐Cacan, Suzanne; Huang, Y. S.; Davignon, Jean

doi:10.1001/archinte.1977.03630220067016

Cited by 52 publications

(2 citation statements)

References 17 publications

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“…Probucol decreases the levels of low and high density lipoproteins 9 – 14 . This study shows that probucol also decreased both LDL‐C and HDL‐C in FH patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of Long‐Term Treatment with Probucol on Serum Lipoproteins in Cases of Familial Hypercholesterolemia in the Elderly

Morisaki¹,

Mori²,

Kobayashi³

et al. 1990

J American Geriatrics Society

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The effect of probucol in lowering serum lipoprotein in young and middle-aged (YM) and elderly (E) patients with familial hypercholesterolemia were compared. Probucol at 1000 mg/day was administered orally to 37 YM patients and 14 E patients for an average of 10 months. Probucol treatment for this period caused significant reductions in the serum levels of total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol, and apoprotein AI, AII, B, and CIII in both groups. The decreases in the levels of total cholesterol, LDL-C, and apoprotein B were greater in the E group than in the YM group (total cholesterol: YM, -19.3%, E, -31.3% [P less than .001]; LDL-C: YM, -17.0%, E, -35.4% [P less than .001]; apoprotein B: YM, -12.3%, E, -28.1% [P less than .01]). The decreases in other parameters in the two groups were not significantly different. The serum probucol concentrations in the YM and E groups were not significantly different. No significant side effects were observed in any patient. Thus probucol reduced the serum level of LDL more in the E group than in the YM group, and did so without any increase in the serum concentration of the drug or in side effects, suggesting that probucol is safe and beneficial for use in elderly patients.

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“…Probucol decreases the levels of low and high density lipoproteins 9 – 14 . This study shows that probucol also decreased both LDL‐C and HDL‐C in FH patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of Long‐Term Treatment with Probucol on Serum Lipoproteins in Cases of Familial Hypercholesterolemia in the Elderly

Morisaki¹,

Mori²,

Kobayashi³

et al. 1990

J American Geriatrics Society

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“…On the other hand, the inverse relationship between plasma levels of high density lipoprotein (HDL) and risk of coronary artery disease have been demonstrated in numerous studies (5)(6)(7)(8)(9). Probucol treatment induces a marked reduction in total cholesterol and LDL cholesterol levels (10)(11)(12)(13)(14)(15) concomitant with a significant reduction in HDL cholesterol and apo A-I levels in serum (16,17).…”

mentioning

confidence: 99%

Effect of Probucol, Pantethine and Their Combinations on Serum Lipoprotein Metabolism and on the Incidence of Atheromatous Lesions in the Rabbit

Tawara

Ishihara

Ogawa

et al. 1986

Japanese Journal of Pharmacology

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Abstract-Effect of probucol, pantethine and their combinations on serum lipoprotein metabolism and on the incidence of atheromatous lesions in aorta and coronary artery was studied in cholesterol-fed rabbits.Probucol treatment (0.5% in diet) resulted in reducing HDL cholesterol and serum apo A-I levels significantly, while pantethine treatment (0.25%-0.75% in diet) tended to increase HDL cholesterol and serum apo A-I levels. Combined treatment with these two drugs showed a sig nificant prevention in the reduction of HDL cholesterol and serum apo A-I levels by probucol alone.Probucol or pantethine treatment reduced effectively (V) LDL cholesterol and serum apo B levels, and these effects were accelerated additively when the two drugs were given concurrently.Atheromatous lesions in aorta and coronary artery in cholesterol-fed rabbits were prevented by the treatment with probucol (0.5% in diet) or pantethine (0.75% in diet) for 24 weeks.The combined treatment with these two drugs showed more marked prevention than either drug alone.From these findings, it is concluded that the combined treatment of probucol with pantethine is effective for improvement of serum lipoprotein disorders and for prevention of the incidence of atheromatous lesions in aorta and coronary artery in cholesterol-fed rabbits.

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QT-Interval Prolongation Produced by Probucol

Klein¹

1981

Arch Intern Med

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Diet and Probucol in Lowering Cholesterol Concentrations

Cited by 52 publications

References 17 publications

Effects of Long‐Term Treatment with Probucol on Serum Lipoproteins in Cases of Familial Hypercholesterolemia in the Elderly

Effects of Long‐Term Treatment with Probucol on Serum Lipoproteins in Cases of Familial Hypercholesterolemia in the Elderly

Effect of Probucol, Pantethine and Their Combinations on Serum Lipoprotein Metabolism and on the Incidence of Atheromatous Lesions in the Rabbit

QT-Interval Prolongation Produced by Probucol

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