Diet and systemic lupus erythematosus: from mouse and monkey to woman?

Environmental Influences on Systemic Lupus Erythematosus Expression

“…Conflicting results have been found with certain dietary factors, some of which may have had supporting evidence from animal models or case reports. For example, an association between alfalfa sprout consumption and development of SLE was seen in the Baltimore Lupus Environmental Study, 19 however a Swedish case-control study found no association between alfalfa sprouts and SLE risk. 20 …”

Dieta e aspectos nutricionais no lúpus eritematoso sistêmico

“…20 Some studies have shown that energy restriction around 30%-40% of the food intake prolongs the life of MRL/lpr mice by inhibiting the development of the lymphoproliferative syndrome, with a reduction in the secretion of IgG 2A (the major antibody of the autoimmune nephritis due to renal deposits) and of the platelet-derived growth factor (PDGF), which can reduce the glomerular lesion of NZB/ NZW mice. 17,[21][22][23] Energy restriction inhibits the decrease of CD4 + and CD8 + T lymphocytes, in addition to attenuating the increase in Th1 cytokines (IL-2 and interferon-γ [IFN-γ]) produced in NZB/ NZW mice. 22 The National Academy of Sciences recommends the intake of 1,800-2,000 calories/day for a sedentary eutrophic adult, and of 2,200-2,500 calories/day in the presence of minimum physical activity.…”

“…17,[21][22][23] Energy restriction inhibits the decrease of CD4 + and CD8 + T lymphocytes, in addition to attenuating the increase in Th1 cytokines (IL-2 and interferon-γ [IFN-γ]) produced in NZB/ NZW mice. 22 The National Academy of Sciences recommends the intake of 1,800-2,000 calories/day for a sedentary eutrophic adult, and of 2,200-2,500 calories/day in the presence of minimum physical activity. 24 Regarding the treatment of excessive weight, the assessment of 86 studies performed by the US National Institutes of Health 25 has shown that a diet of 1,000-1,200 kcal/ day results in the loss of 7-13 kg (mean of 8%) in 3-6 months, with a mean 10-cm reduction in abdominal fat in 6-24 weeks.…”

“…17,34 The Baltimore Lupus Environmental Study (BALES) has also shown a signifi cant association between alfalfa sprout consumption and the appearance of SLE, suggesting that none of its derivatives should be used. 22,34 In addition, in patients with SLE and inactive disease, the consumption of 8-15 tablets of alfalfa per day has been shown to reactivate the clinical symptoms of the disease and its serological aspects. 17 Although the fi ndings have suggested that alfalfa derivatives should not be used in SLE, it is worth noting that cooking and autoclaving apparently destroy their deleterious effects without damaging their lipid-lowering properties.…”

“…Inhibits the reduction of CD4 + and CD8 + T lymphocytes and attenuates ↑ of Th1 (IL-2 and IFN-γ) 22 ↓ progression of autoimmune diseases 20 ↓ secretion of IgG 2A 17,[21][22][23] Excessive consumption Metabolic syndrome Higher risk of cardiovascular diseases Disease activity 22 ↑ weight and obesity…”