Diet and the microbiota–gut–brain-axis: a primer for clinical nutrition

Ribeiro, Gabriela; Ferri, Aimone; Clarke, Gerard; Cryan, John F.

doi:10.1097/mco.0000000000000874

Cited by 33 publications

(20 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the mechanisms linking MS-diet to depression are uncertain, a role of the gut-brain axis has been suggested (27). Inflammation is known to play a key role in MS progression (46) and the anti-inflammatory and neuroprotective effects of fruit/vegetables and of low saturated fat diet have been documented (9,47,48). Our findings may be in part explained by the anti-inflammatory effects of a low saturated fat diet such as the OMS-diet.…”

Section: Discussionmentioning

confidence: 50%

Self-reported ongoing adherence to diet is associated with lower depression, fatigue, and disability, in people with multiple sclerosis

Jelinek

Simpson‐Yap

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

IntroductionIncreasingly, dietary improvements have been shown to have positive associations with health outcomes in people with multiple sclerosis (pwMS). However, adhering to a MS-specific or high-quality diet may be a challenge. We therefore assessed the level of diet-adherence necessary to improve health outcomes of depression, fatigue, and disability.MethodsData from an international population of pwMS followed over 7.5 years (n = 671) were analyzed. Self-reported diet quality via diet habits questionnaire (DHQ), and adherence to six MS-diets [Ashton Embry Best Bet, McDougall, Overcoming MS (OMS), Paleolithic (Paleo), Swank, and Wahls] were queried at two timepoints. Four levels of diet adherence were assessed: non-adherence at either timepoint; ceased at second timepoint; commenced at second timepoint; and ongoing at both timepoints. Associations between adherence to OMS and high-quality diet (DHQ score > median) with depression, fatigue, and disability, were assessed by log-binomial regression models adjusted for confounders.ResultsForty-two percent of pwMS reported ongoing-adherence to a MS-diet at both timepoints, OMS (33%), Swank (4%), Wahls (1.5%), other (<1%). Of these, only OMS-diet adherence was analyzed for associations due to data availability. Ongoing-adherence to the OMS-diet or a high-quality diet, was associated with lower depression compared to non-adherence [OMS: Risk ratios (RR) = 0.80, p = 0.021; DHQ: RR = 0.78, p = 0.009] and ceased-adherence (OMS: RR = 0.70, p = 0.008; DHQ: RR = 0.70, p = 0.010), respectively. Ongoing-adherence to OMS-diet was associated with lower fatigue (RR = 0.71, p = 0.031) and lower severe disability (RR = 0.43, p = 0.033) compared to ceased-adherence.ConclusionResults suggest potential benefits of adherence to the OMS- or a high-quality diet on MS health outcomes, with ongoing-adherence likely best. Diet modification and maintenance may serve as a point of intervention to manage MS symptoms, especially depression, in pwMS.

show abstract

Section: Discussionmentioning

confidence: 50%

Self-reported ongoing adherence to diet is associated with lower depression, fatigue, and disability, in people with multiple sclerosis

Jelinek

Simpson‐Yap

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…In addition, new clinical trials indicated that the gut-microbiota–brain axis pathways and mechanisms are prone to dietary modulation and are of vital interest in clinical nutrition. As a matter of fact, dietary interventions and supplementation with probiotics and prebiotics can reshape the bacterial composition and are now administered as “psychobiotics” to treat neurological disorders because of their beneficial effects on the brain [ 176 ]. This means that by reshaping the GM, the whole gut-microbiota-BBB axis is positively modulated.…”

Section: Beneficial Modulation Of the Gut-microbiota–brain Axismentioning

confidence: 99%

Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review

Diwan

Lahimer

Bach

et al. 2023

IJMS

View full text Add to dashboard Cite

Accumulating evidence indicates that chronic exposure to a low level of pesticides found in diet affects the human gut-microbiota–blood–brain barrier (BBB) axis. This axis describes the physiological and bidirectional connection between the microbiota, the intestinal barrier (IB), and the BBB. Preclinical observations reported a gut microbial alteration induced by pesticides, also known as dysbiosis, a condition associated not only with gastrointestinal disorders but also with diseases affecting other distal organs, such as the BBB. However, the interplay between pesticides, microbiota, the IB, and the BBB is still not fully explored. In this review, we first consider the similarities/differences between these two physiological barriers and the different pathways that link the gut microbiota and the BBB to better understand the dialogue between bacteria and the brain. We then discuss the effects of chronic oral pesticide exposure on the gut-microbiota-BBB axis and raise awareness of the danger of chronic exposure, especially during the perinatal period (pregnant women and offspring).

show abstract

“…The Mediterranean diet constitutes a food model that characterizes not only a lifestyle but also a culture and has been indicated as a hub for improving health, quality of life, and life span. Numerous studies have highlighted the positive correlation between MD and longevity; individuals who adhere to a nutritional style such as this have a longer life expectancy [ 81 , 82 ]. Moreover, the Mediterranean diet prevents many metabolic, cardiovascular, and neurodegenerative diseases; insulin resistance; and different types of cancer [ 83 , 84 ].…”

Section: The Mediterranean Diet (Md)mentioning

confidence: 99%

The Mediterranean Lifestyle to Contrast Low-Grade Inflammation Behavior in Cancer

Divella¹,

Marino

Infusino

et al. 2023

Nutrients

View full text Add to dashboard Cite

A healthy diet and an active lifestyle are both effective ways to prevent, manage, and treat many diseases, including cancer. A healthy, well-balanced diet not only ensures that the body gets the right amount of nutrients to meet its needs, but it also lets the body get substances that protect against and/or prevent certain diseases. It is now clear that obesity is linked to long-term diseases such as heart disease, diabetes, and cancer. The main reasons for people being overweight or obese are having bad eating habits and not moving around enough. Maintaining weight in the normal range may be one of the best things to avoid cancer. It has been scientifically proven that those who perform regular physical activity are less likely to develop cancer than those who lead a sedentary lifestyle. Moving regularly not only helps to maintain a normal body weight, avoiding the effects that favor tumor growth in overweight subjects, but also makes the immune system more resistant by counteracting the growth of tumor cells. Physical activity also helps prevent cardiovascular and metabolic diseases. In this review, it is highlighted that the association between the Mediterranean diet and physical activity triggers biological mechanisms capable of counteracting the low-grade chronic inflammation found in patients with cancer. This assumes that healthy lifestyles associated with cancer therapies can improve the expectations and quality of life of cancer patients.

show abstract

Diet and the microbiota–gut–brain-axis: a primer for clinical nutrition

Cited by 33 publications

References 54 publications

Self-reported ongoing adherence to diet is associated with lower depression, fatigue, and disability, in people with multiple sclerosis

Self-reported ongoing adherence to diet is associated with lower depression, fatigue, and disability, in people with multiple sclerosis

Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review

The Mediterranean Lifestyle to Contrast Low-Grade Inflammation Behavior in Cancer

Contact Info

Product

Resources

About