Diet and Thrombosis Risk: Nutrients for Prevention of Thrombotic Disease

Phang, Melinda; Lazarus, Sheryl A.; Wood, Lisa G.; Garg, Manohar L.

doi:10.1055/s-0031-1273084

Cited by 59 publications

(30 citation statements)

References 116 publications

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“…Dietary supplements are widely used for improving the integrity and function of veins in the lower limbs, in order to increase the integrity of the tissue to improve the vein's function [47]. They also decrease the capillary's permeability by reducing the number and size of pores in the capillary's walls, improve the tone of or dilate the blood vessels and affect blood-clotting mechanisms [47]. In particular, we found that use of ginkgo showed a trend for a protective role in relation to CCSVI; however, because only 13% of participants answered this question, the data need to be confirmed in further studies.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers

et al. 2011

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BackgroundThe role of intra- and extra-cranial venous system impairment in the pathogenesis of various vascular, inflammatory and neurodegenerative neurological disorders, as well as in aging, has not been studied in detail. Nor have risk factors been determined for increased susceptibility of venous pathology in the intra-cranial and extra-cranial veins. The aim of this study was to investigate the association between presence of a newly proposed vascular condition called chronic cerebrospinal venous insufficiency (CCSVI) and environmental factors in a large volunteer control group without known central nervous system pathology.Methods and FindingsThe data were collected in a prospective study from 252 subjects who were screened for medical history as part of the entry criteria and participated in the case-control study of CCSVI prevalence in multiple sclerosis (MS) patients, and then were analyzed post-hoc. All participants underwent physical and Doppler sonography examinations, and were assessed with a structured environmental questionnaire. Fullfilment of ≥2 positive venous hemodynamic (VH) criteria on Doppler sonography was considered indicative of CCSVI diagnosis. Risk and protective factors associated with CCSVI were analyzed using logistic regression analysis. Seventy (27.8%) subjects presented with CCSVI diagnosis and 153 (60.7%) presented with one or more VH criteria. The presence of heart disease (p = .001), especially heart murmurs (p = .007), a history of infectious mononucleosis (p = .002), and irritable bowel syndrome (p = .005) were associated with more frequent CCSVI diagnosis. Current or previous smoking (p = .029) showed a trend for association with more frequent CCSVI diagnosis, while use of dietary supplements (p = .018) showed a trend for association with less frequent CCSVI diagnosis.ConclusionsRisk factors for CCSVI differ from established risk factors for peripheral venous diseases. Vascular, infectious and inflammatory factors were associated with higher CCSVI frequency.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers

et al. 2011

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“…Dietary flavonoids also include the anthocyanins cyanidin, delphinidin, malvidin, pelargonidin, peonidin and petunidin together with the flavanones hesperetin and naringenin, the flavones apigenin and luteolin, and the flavonols myricetin, kaempferol, and quercetin (Grotewold, 2006b). Apart from antioxidant activities, food-derived flavonoids were shown to reduce the incidence of atherosclerosis (Terao, 2009), cancer (Clere et al, 2011), cardiovascular diseases (Bojić, 2011), diabetes (Zheng et al, 2011), thrombosis (Phang et al, 2011), inflammation in arthritis (Gonzalez et al, 2011), neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases (Mandel et al, 2011), obesity (Birari et al, 2011), hyperlipidemia (Wang et al, 2011), nerve injury (Jäger and Saaby, 2011) and hypertension (Cassidy et al, 2011). …”

Section: Flavonoids As Nutraceuticalsmentioning

confidence: 99%

Flavonoids: a metabolic network mediating plants adaptation to their real estate

2014

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From an evolutionary perspective, the emergence of the sophisticated chemical scaffolds of flavonoid molecules represents a key step in the colonization of Earth’s terrestrial environment by vascular plants nearly 500 million years ago. The subsequent evolution of flavonoids through recruitment and modification of ancestors involved in primary metabolism has allowed vascular plants to cope with pathogen invasion and damaging UV light. The functional properties of flavonoids as a unique combination of different classes of compounds vary significantly depending on the demands of their local real estate. Apart from geographical location, the composition of flavonoids is largely dependent on the plant species, their developmental stage, tissue type, subcellular localization, and key ecological influences of both biotic and abiotic origin. Molecular and metabolic cross-talk between flavonoid and other pathways as a result of the re-direction of intermediate molecules have been well investigated. This metabolic plasticity is a key factor in plant adaptive strength and is of paramount importance for early land plants adaptation to their local ecosystems. In human and animal health the biological and pharmacological activities of flavonoids have been investigated in great depth and have shown a wide range of anti-inflammatory, anti-oxidant, anti-microbial, and anti-cancer properties. In this paper we review the application of advanced gene technologies for targeted reprogramming of the flavonoid pathway in plants to understand its molecular functions and explore opportunities for major improvements in forage plants enhancing animal health and production.

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“…Nahrungsergänzungsmittel, welche eine hemmende Wirkung auf die Thrombozyten haben können (z. B. Gingko, [24]). Eine ebenfalls häufige Ursache einer Störung der primären Hämostase ist das (meist angeborene) Willebrand-Syndrom [19].…”

Section: Präoperative Gerinnungsdiagnostikunclassified

Aktuelle Gerinnungsdiagnostik in der Intensivmedizin

Lang¹

2011

Med Klin

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In the preoperative setting, a standardized questionnaire on bleeding history cannot be replaced by the Quick test or activated partial thromboplastin time (APTT) measurement. Thrombelastometry provides rapid measurement of coagulation in the intra- and postoperative settings. Besides the Quick test and APTT, thrombelastometry provides information about clot firmness and clot stability. This allows goal-directed management in coagulopathy, which results in a reduction of transfusion of blood products. Furthermore, this can lead to not only an overall reduced length of stay in the hospital, but also in the intensive care unit, thus, contributing to a significant cost reduction.

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Diet and Thrombosis Risk: Nutrients for Prevention of Thrombotic Disease

Cited by 59 publications

References 116 publications

Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers

Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers

Flavonoids: a metabolic network mediating plants adaptation to their real estate

Aktuelle Gerinnungsdiagnostik in der Intensivmedizin

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