Diet and vascular risk

Gómez-Delgado, Francisco; Romero-Cabrera, Juan Luis; Pérez‐Martínez, Pablo

doi:10.1097/hco.0000000000000960

Cited by 7 publications

(7 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While regulatory bodies generally consider ASwt safe at recommended intake levels, some observational studies suggest an association between high ASwt consumption and an increased risk of CVD. [5][6][7][8] This study did reveal potential interactions between ASwt, particularly As and Su, with cellular targets (CAPN1, LTA4H, MKNK2, ITGA2, and HDAC1) involved in various physiological processes. Notably, some of these targets are linked to functions relevant to CVD development.…”

Section: Discussionmentioning

confidence: 99%

“…Despite safety evaluations, several studies suggest potential health risks associated with chronic consumption of ASwt. A WHO systematic review 3 revealed that replacement of ASwt with sugar does not provide a means for weight management in the long-term, and several studies have discovered a positive correlation between long term ASwt consumption and risk of developing cardiovascular disease [5][6][7][8] , type 2 diabetes mellitus 6,[8][9][10][11] , and mortality in adults 6,8,9,12 . Current literature also reveals other concerning associations between ASwt consumption and various routinely observed clinical conditions, including heightened risks of developing cancer [13][14][15] , chronic kidney disease 16,17 , adiposity related diseases 8,9,18,19 , as well as non-alcoholic fatty liver disease 20 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative network pharmacology of artificial sweeteners to understand Its health consequences

Tankala,

Kumar

2024

Preprint

View full text Add to dashboard Cite

Background: Artificial sweeteners (ASwt) are widely consumed sugar substitutes, but their long-term health effects remain a subject of debate. While regulatory bodies generally consider them safe at recommended doses, concerns persist regarding potential adverse effects. This study aimed to investigate the interactions between ASwt and biological targets using in silico analysis, focusing on target affinity, selectivity, and tissue expression. Methods: Five common ASwt, acesulfame K (Ac), aspartame (As), sucralose (Su), steviol (St), and saccharin (Sa) were evaluated. Their target interactions were predicted using a cheminformatics approach, analysing affinity towards functional groups and protein targets. Concentration/affinity (C/A) ratios were calculated to assess the likelihood of target activation at achievable doses. Expression of high-affinity targets with significant C/A ratios in various organs was assessed using the Human Protein Atlas database. Results: The ASwt displayed potential to modulate most of the functional groups at physiologically feasible affinities. Ac exhibited a broad range of targets, while St showed a preference for kinases and proteases. Notably, As and Su demonstrated interactions with membrane receptors and kinases. C/A ratio analysis revealed potential concerns for As and Su. Several of its targets, including ROCK2, ACE, ITGA2/5, PIM2, KDM5C, PIM1, SLC1A2, SETD2, CAPN1, LTA4H, MKNK2, HDAC1 and CDK, showed high C/A ratios, suggesting possible functional modulation at achievable intake levels. Organ specific expression analysis identified the endocrine, respiratory, renal, reproductive, central nervous, digestive, and musculoskeletal systems as a region particularly susceptible due to the high expression of high affinity targets linked to cell growth, extracellular matrix, epigenetic regulations, and inflammation. Interestingly, 30 tissues expressed high-affinity targets for both As and Su, while 14 tissues exclusively expressed targets for As. Conclusion: This study highlights the potential for ASwt to interact with various biological targets, particularly As and Su. The high C/A ratios of some As targets and the tissue-specific expression patterns suggest potential safety concerns that require in vivo validation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative network pharmacology of artificial sweeteners to understand Its health consequences

Tankala,

Kumar

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…It has been widely demonstrated that lifestyle improvement is the cornerstone of CVD prevention [ 21 ]. Among lifestyle strategies, a healthy diet is one of the most effective strategies for attaining BP reduction and control [ 22 ]. In effect, a large body of evidence suggests that some food or food components—along with low-dose daily intake of sodium—might provide a specific advantage for BP [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Self-Reported Coffee Consumption and Central and Peripheral Blood Pressure in the Cohort of the Brisighella Heart Study

Cicero

Fogacci²,

D’Addato³

et al. 2023

Nutrients

View full text Add to dashboard Cite

Even though coffee consumption has been clearly related to a number of benefits to the cardiovascular system, its effect on blood pressure (BP) has not been fully elucidated. In this sub-analysis of the Brisighella Heart Study (BHS), we compared central and peripheral BP values in a sub-cohort of 720 men (47.9%) and 783 women (52.1%) reporting the drinking of different amounts of coffee each day, for whom a full set of clinical, laboratory and hemodynamic parameters was available. According to our observations, moderate coffee drinking was associated to either higher levels of systolic BP (SBP) compared to those with heavy coffee consumption or lower SBP than that in the non-coffee drinking group (p-value for trend <0.05). In particular, people who drank 2 cups of coffee per day and people who drank >3 cups per day had lower SBP than non-coffee drinkers by 5.2 ± 1.6 mmHg (p = 0.010) and 9.7 ± 3.2 mmHg, respectively (p = 0.007). Similar trends were also observed for peripheral pulse pressure (PP), aortic BP and aortic PP. In the age-adjusted multiple linear regression model, negative predictors of SBP, PP, aortic BP and aortic PP were the estimated glomerular filtration rate (eGFR), female sex and coffee consumption. Positive predictors included body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C). Then, our findings show that regular coffee drinking is associated with lower SBP, PP, aortic BP and aortic PP, but with similar arterial stiffness.

show abstract

“…In addition to epidemiological data (often related to the Mediterranean diet [ 118 ]) linking a plant-based diet with lower blood pressure [ 119 ], some human studies provided direct evidence of the (poly)phenol-induced increase in vasomotion. Three examples are worth mentioning.…”

Section: Methodsmentioning

confidence: 99%

Plant-Based Diets Reduce Blood Pressure: A Systematic Review of Recent Evidence

Tomé‐Carneiro

Visioli

2023

Curr Hypertens Rep

View full text Add to dashboard Cite

Purpose of Review Accumulating data on the consumption of plant-based diets and their impact on blood pressure indicate a consensus that plant-based diets are linked to reduced blood pressure. The suggested mechanisms of action are manifold, and, in this systematic review, we provide a summary of the most recent findings on plant-based diets and their impact on blood pressure, along with an analysis of the molecules accountable for the observed effects. Recent Findings The overwhelming majority of intervention studies demonstrate that plant-based diets result in lower blood pressure readings when compared to diets that are based on animal products. The various mechanisms of action are being clarified. Summary The data discussed in this systematic review allow us to conclude that plant-based diets are associated with lower blood pressure and overall better health outcomes (namely, on the cardiovascular system) when compared to animal-based diets. The mechanisms of action are being actively investigated and involve many macro- and micronutrients plentiful in plants and the dishes prepared with them.

show abstract

Diet and vascular risk

Cited by 7 publications

References 53 publications

Comparative network pharmacology of artificial sweeteners to understand Its health consequences

Comparative network pharmacology of artificial sweeteners to understand Its health consequences

Self-Reported Coffee Consumption and Central and Peripheral Blood Pressure in the Cohort of the Brisighella Heart Study

Plant-Based Diets Reduce Blood Pressure: A Systematic Review of Recent Evidence

Contact Info

Product

Resources

About