Diet as an environmental trigger in inflammatory bowel disease: a retrospective comparative study in two European cohorts

Preda, Carmen Monica; Manuc, Teodora; Chifulescu, Andreea Elena; Istrătescu, Doina; Louis, Édouard; Băicuș, Cristian; Sandra, Irina; Diculescu, Mihai Mircea; Reenaers, Cathérine; Kemseke, Catherine Van; Nițescu, Maria; Tieranu, Cristian; Popescu, Miruna; Tugui, Letitia; A, Andrei; Ciora, Cosmin-Alexandru; Gherorghe, Iliana simona; Manuc, Mircea

doi:10.17235/reed.2020.6552/2019

Cited by 15 publications

(19 citation statements)

References 30 publications

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“…Processed meat was avoided only by 6.6% of our patients, though it has been found that a high consumption of foods containing linoleic acid, red meat, and processed meats increases the risk of developing IBD, especially UC [3,17,18].…”

Section: Discussionmentioning

confidence: 81%

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Perception of the Role of Food and Dietary Modifications in Patients with Inflammatory Bowel Disease: Impact on Lifestyle

et al. 2021

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Background: Diet has a relevant role in triggering symptoms in inflammatory bowel disease (IBD) from the patients’ perspective, but there is gap the between patients’ and doctors’ perceptions. Few studies have addressed this topic. The aim of this study was to evaluate food habits and nutrition knowledge in a homogeneous cohort of patients with IBD from southern Italy. Methods: 167 consecutive patients with IBD were recruited. The survey was based on the administration of a semi-structured questionnaire assessing demographics, disease features, dietary behavior, and food intolerance. Results: The majority of patients did not consider food a cause of their disease. However more than 80% changed their diet after the diagnosis and most report an improvement in symptoms. Spiced and seasoned foods, dairy products, vegetables, and fruit were often avoided. A dairy-free diet was adopted by 33.7%. Food choices were based on self-experience and not on medical counselling. Dietary modifications deeply impact on lifestyle. Conclusions: Most of the patients with IBD set diet and lifestyle on self-experience and give up many foods. This has an impact on psychosocial functioning and can lead to nutritional deficiencies. High quality studies are warranted to assess evidence-based dietary strategies and develop patient-targeted dietary recommendations.

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Section: Discussionmentioning

confidence: 81%

“…Previous studies [16,17] showed that the incidence of IBD is higher in patients who do not eat fruit and vegetables but eat a lot of fats and proteins. Recently, the International Organization for the Study of IBD (IOIBD) recommended increasing exposure to fruit and vegetables in Crohn's disease [18].…”

Section: Discussionmentioning

confidence: 99%

Perception of the Role of Food and Dietary Modifications in Patients with Inflammatory Bowel Disease: Impact on Lifestyle

et al. 2021

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“…The gastrointestinal (GI) tract is a complex microenvironment; the molecular crosstalk among the human host, luminal resident microbes, and nutritional intakes plays a pivotal role in physiology, in both physiological and pathological conditions. Epidemiological data indicate the role of diet in IBD onset and relapse, but dietary adjuvant intervention to induce or maintain IBD remission has been little considered in many clinical studies [ 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study

et al. 2022

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Antioxidants are privileged candidates for the development of adjuvants able to improve the efficiency of pharmacological therapies, particularly for chronic inflammatory syndromes. During the last 20 years, anti-TNFα (tumor necrosis factor alpha) monoclonal antibodies infusion has been the biological therapy most frequently administered but there is still large space for improvement in disease remission rates and maintenance. In this context, nutritional bioactive compounds contained in dietary patterns or included as supplements, may act as adjuvants for the induction and maintenance of IBD (inflammatory bowel diseases) remission. To verify this possibility, a single-center preliminary study (SI-CURA, Soluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite UlceRosA) was designed and carried out to evaluate whether a daily administration of purple corn supplement could improve the response to Infliximab (IFX) infusion of IBD patients with both Crohn’s disease (CD) and ulcerative colitis (UC). A cohort of 47 patients was enrolled in the study. Biological samples were collected before the first and the third IFX infusion. All patients received nutritional guidelines, 27 of them received commercial red fruit tea with low anthocyanins content, while 20 received a purple corn supplement with a high anthocyanin content. Results show that the administration of an antioxidant-enriched purple corn supplement could improve IFX-mediated disease remission in terms of circulating inflammatory markers. Comparison between CD and UC patients revealed that, at this anthocyanin dosage, the purple corn extract administration improved the IFX response in CD but not in UC patients. Our results may pave the way for a new metacentric study of CD patients, recruiting a wider cohort and followed-up over a longer observational time.

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“…Common pro-inflammatory foods are red meat, refined carbohydrates, sweetened beverages, sweets, fried food, margarine, etc. ( Supplementary Table 1 ) ( 27 , 28 ). High consumption of processed red meat increases the risk of chronic obstructive pulmonary disease ( 29 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Diet-Related Inflammation and COPD: Findings From NHANES III

et al. 2021

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Background and Aims: Little is known about diet-related inflammation in chronic obstructive pulmonary disease (COPD). In this study, we aimed to explore the association between COPD and dietary inflammatory index (DII) scores in adults over 40 years old.Methods: Data were obtained from the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES). In the present study, 9,929 participants were included and analyzed. The DII score was calculated and divided into tertiles. Logistic regression analysis was performed to determine the odds ratios of DII tertiles.Results: Participants were categorized into COPD (565, 5.69%) and non-COPD groups (9,364, 94.31%) according to interview information. COPD individuals had higher DII scores than non-COPD individuals (0.429 ± 1.809 vs. −0.191 ± 1.791, p < 0.001). The highest DII score tertile included 46.55% of COPD individuals was associated with lower family incomes and education and a higher smoking rate (p < 0.01). The odds ratios (95% CIs) of COPD according to logistic regression were 0.709 (0.512–0.982) for T1 and 0.645 (0.475–0.877) for T2 of the DII score (p = 0.011).Conclusion: Higher DII scores were positively correlated with COPD in participants over 40 years old. These results further support that diet can be used as an intervention strategy for COPD management.

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Diet as an environmental trigger in inflammatory bowel disease: a retrospective comparative study in two European cohorts

Cited by 15 publications

References 30 publications

Perception of the Role of Food and Dietary Modifications in Patients with Inflammatory Bowel Disease: Impact on Lifestyle

Perception of the Role of Food and Dietary Modifications in Patients with Inflammatory Bowel Disease: Impact on Lifestyle

Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study

Association Between Diet-Related Inflammation and COPD: Findings From NHANES III

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