Diet, body composition, and physical fitness influences on IGF-I bioactivity in women

Karl, J. Philip; Alemany, Joseph A.; Koenig, Chad; Kraemer, William J.; Frystyk, Jan; Flyvbjerg, Allan; Young, Andrew; Nindl, Bradley C.

doi:10.1016/j.ghir.2009.04.001

Cited by 22 publications

(9 citation statements)

References 31 publications

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“…However, in contrast to our expectations, bioactive IGF1 correlated with neither measures of muscle strength nor body composition. In contrast to this, Karl et al (29) found that bioactive IGF1 correlated inversely with the percentage of body fat determined by dual-energy X-ray absorptiometry in 44 young females. However, in the same study other measures of body composition did not correlate with either IGF1 or bioactive IGF1 (29).…”

Section: Discussionmentioning

confidence: 85%

Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults

Vestergaard

Hansen

Frystyk

et al. 2014

European Journal of Endocrinology

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Objective: Senescent changes in body composition and muscle strength are accompanied by reduced production of GH and IGF1, but the causal relationship remains elusive. We speculate that serum bioactive IGF1, measured by the IGF1 kinase receptor activation assay, is closer related to human physiological ageing than total IGF1 measured by immunoassay. Design: We conducted a cross-sectional study in 150 adult males and females, between 20 and 70 years. After an overnight fasting, serum levels of bioactive IGF1, total IGF1 and IGF-binding protein 1 (IGFBP1) and IGFBP3 were assessed. Furthermore, body composition and muscle strength was measured. Results: Total IGF1 levels were higher in females (PZ0.048). Bioactive IGF1 were identical in males and females (PZ0.31), decreasing with age. Total IGF1 tended to decrease more with age compared with bioactive IGF1 (K1.48 vs K0.89 percent/year, PZ0.052). Total body fat (TBF) was lower and BMI was higher in males (P!0.001 and PZ0.005), and both increased with age. Knee extension and elbow flexion force were higher in males (PZ0.001 and PZ0.001), but decreased with age in both genders.Total but not bioactive IGF1 was positively correlated to TBF, knee extension and muscle function in males. In multiple linear regression, only age predicted total IGF1, whereas age and IGFBP1 predicted bioactive IGF1. Conclusions: Bioactive IGF1 tends to decrease to a lesser extent than total IGF1 with age and was not correlated with measures of body composition or muscle strength. Therefore, levels of circulating bioactive IGF1 does not appear to be a better biomarker of physiological ageing than total IGF1.

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Section: Discussionmentioning

confidence: 85%

Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults

Vestergaard

Hansen

Frystyk

et al. 2014

European Journal of Endocrinology

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“…As to physical activity, although its role in regulating the expression of specific IGF-1 isoforms has been widely studied, data in the literature regarding humans are often contradictory and are affected by many uncontrolled variables such as the lack of dietary control, heterogeneity of subjects, their physical fitness, differences in proposed physical exercise, and time course of sampling [158–160]. …”

Section: Ros and Igf-1 Signalingmentioning

confidence: 99%

Reactive Oxygen Species in Skeletal Muscle Signaling

Barbieri

Sestili

2012

Journal of Signal Transduction

320

296

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Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic cells' life. Up to the 1990s of the past century, ROS have been solely considered as toxic species resulting in oxidative stress, pathogenesis and aging. However, there is now clear evidence that ROS are not merely toxic species but also—within certain concentrations—useful signaling molecules regulating physiological processes. During intense skeletal muscle contractile activity myotubes' mitochondria generate high ROS flows: this renders skeletal muscle a tissue where ROS hold a particular relevance. According to their hormetic nature, in muscles ROS may trigger different signaling pathways leading to diverging responses, from adaptation to cell death. Whether a “positive” or “negative” response will prevail depends on many variables such as, among others, the site of ROS production, the persistence of ROS flow or target cells' antioxidant status. In this light, a specific threshold of physiological ROS concentrations above which ROS exert negative, toxic effects is hard to determine, and the concept of “physiologically compatible” levels of ROS would better fit with such a dynamic scenario. In this review these concepts will be discussed along with the most relevant signaling pathways triggered and/or affected by ROS in skeletal muscle.

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“…A recent cross-sectional study that involved 44 young women showed a significant association between IGF-1 serum levels and selenium from dietary sources ( r = 0.41, p < 0.01) [83]. …”

Section: Minerals and Igf-1 In The Fire Of Frailtymentioning

confidence: 99%

IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty

et al. 2013

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The decline in functional capacity is a heterogeneous phenomenon in the elderly. An accelerated ageing determines a frail status. It results in an increased vulnerability to stressors for decreased physiological reserves. The early identification of a frail status is essential for preventing loss of functional capacity, and its clinical consequences. Frailty and mobility limitation result from an interplay of different pathways including multiple anabolic deficiency, inflammation, oxidative stress, and a poor nutritional status. However, the age-related decline in insulin-like growth factor 1 (IGF-1) bioactivity deserves special attention as it could represent the ideal crossroad of endocrine, inflammatory, and nutritional pathways to frailty. Several minerals, namely magnesium, selenium, and zinc, appear to be important determinants of IGF-1 bioactivity. This review aims to provide an overview of the potential usefulness of nutrients modulating IGF-1 as potential therapeutic targets in the prevention of mobility limitation occurring in frail older subjects.

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Diet, body composition, and physical fitness influences on IGF-I bioactivity in women

Cited by 22 publications

References 31 publications

Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults

Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults

Reactive Oxygen Species in Skeletal Muscle Signaling

IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty

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