Diet‐Derived Advanced Glycation End Products Are Major Contributors to the Body's AGE Pool and Induce Inflammation in Healthy Subjects

Uribarri, Jaime; Cai, Weiping; Sandu, Oana; Peppa, Μelpomeni; Goldberg, Teresia; Vlassara, Helen

doi:10.1196/annals.1333.052

Cited by 383 publications

(293 citation statements)

References 18 publications

(79 reference statements)

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“…Prominent examples are adducts of glucose to protein or lipids as a consequence of thermal processing of food [49]. Deficiencies of vitamin D and calcium have also been linked with type 2 diabetes [50].…”

Section: Other Food Componentsmentioning

confidence: 99%

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

Kolb¹,

2009

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The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary lifestyle, sleep deprivation and depression) have been found to induce local or systemic low-grade inflammation that is usually transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in the pancreatic islets. Chronic low-grade inflammation will eventually lead to overt diabetes if counter-regulatory circuits to inflammation and metabolic stress are compromised because of a genetic and/or epigenetic predisposition. Hence, it is not the lifestyle change per se but a deficient counter-regulatory response in predisposed individuals which is crucial to disease pathogenesis. Novel approaches of intervention may target these deficient defence mechanisms.

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Section: Other Food Componentsmentioning

confidence: 99%

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

Kolb¹,

2009

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“…In earlier CKD, increased skin AF has been shown to be associated with a wide range of poor prognostic factors, including anemia, proteinuria, diabetes, age, and eGFR, in cross-sectional analysis (2). Dietary modification to reduce exogenous AGEs may be important (4). However, the relationship between elevated skin AF and subsequent adverse outcomes in earlier stages of CKD is not yet known.…”

Section: Introductionmentioning

confidence: 99%

“…Accumulation also occurs from exogenous sources, principally food cooked at high temperature, and AGEs formed by smoking. In addition, AGEs are normally excreted by the kidneys and therefore, accumulate with decreased renal function (2)(3)(4)(5)(6). In CKD, AGE accumulation may be exacerbated by increased formation, because dicarbonyl and oxidative stress are increased with reduced renal function, and there is increased availability of precursor compounds (such as oxidized ascorbic acid arising in people on hemodialysis) (7).…”

Section: Introductionmentioning

confidence: 99%

Skin Autofluorescence and All-Cause Mortality in Stage 3 CKD

Fraser

Roderick

McIntyre

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Novel markers may help to improve risk prediction in CKD. One potential candidate is tissue advanced glycation end product accumulation, a marker of cumulative metabolic stress, which can be assessed by a simple noninvasive measurement of skin autofluorescence. Skin autofluorescence correlates with higher risk of cardiovascular events and mortality in people with diabetes or people requiring RRT, but its role in earlier CKD has not been studied.Design, setting, participants, & measurements A prospective cohort of 1741 people with CKD stage 3 was recruited from primary care between August 2008 and March 2010. Participants underwent medical history, clinical assessment, blood and urine sampling for biochemistry, and measurement of skin autofluorescence. Kaplan-Meier plots and multivariate Cox proportional hazards models were used to investigate associations between skin autofluorescence (categorical in quartiles) and all-cause mortality.Results In total, 1707 participants had skin autofluorescence measured; 170 (10%) participants died after a median of 3.6 years of follow-up. The most common cause of death was cardiovascular disease (41%). Higher skin autofluorescence was associated significantly with poorer survival (all-cause mortality, P,0.001) on KaplanMeier analysis. Univariate and age/sex-adjusted Cox proportional hazards models showed that the highest quartile of skin autofluorescence was associated with all-cause mortality (hazard ratio, 2.64; 95% confidence interval, 1.71 to 4.08; P,0.001 and hazard ratio, 1.84; 95% confidence interval, 1.18 to 2.86; P=0.003, respectively, compared with the lowest quartile). This association was not maintained after additional adjustment to include cardiovascular disease, diabetes, smoking, body mass index, eGFR, albuminuria, and hemoglobin.Conclusions Skin autofluorescence was not independently associated with all-cause mortality in this study. Additional research is needed to clarify whether it has a role in risk prediction in CKD.

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“…dAGEs are an important contributor to the total pool of AGEs formed in the living organism and can induce an oxidant stress and inflammation resulting in an increasing risk of diabetic and cardiovascular diseases [Uribarri et al, 2005;Yamagishi et al, 2007;Ames, 2009]. Furthermore, the list of dAGEs obtained from food products with special guidelines for diabetic patients was elaborated by Uribarii et al [2010].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the In Vitro Inhibitory Activity of Rye-Buckwheat Ginger Cakes with Rutin on the Formation of Advanced Glycation End-Products (AGEs)

Przygodzka¹,

Zieliński²

2015

Pol. J. Food Nutr. Sci.

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In this study, the relationship between the inhibitory effects of extracts from rye-buckwheat ginger cakes supplemented with low and high rutin dosage baked without or with dough fermentation step on the formation of fluorescent advanced glycation end-products (AGEs), and phenolic compounds, rutin, D-chiro-inositol and antioxidant capacity were addressed. The cakes were based on rye flour substituted by light buckwheat flour or flour from roasted buckwheat groats at 30% level, and were produced with or without dough fermentation step. The inhibitory effect against AGEs formation was studied in bovine serum albumin (BSA)-glucose and BSA-methylglyoxal (MGO) systems. The antioxidant capacity was measured by 2,2-diphenyl--1-picrylhydrazyl (DPPH) and cyclic voltammetry (CV), rutin and D-chiro-inositol contents by HPLC and total phenolics (TPC) by spectrophotometric assays. The study showed the inhibitory effects of extracts from rye-buckwheat ginger cakes supplemented with low and high rutin dosage. The results of the inhibitory activity were highly correlated in two applied model systems. Enrichment of rye-buckwheat ginger cakes with rutin improved their antioxidant properties. The correlation studies showed that the inhibitory effects of rye-buckwheat ginger cakes produced with dough fermentation step and enhanced with rutin against formation of AGEs were highly correlated with TPC, rutin and D-chiro-inositol contents, and antioxidant capacity. Moreover, the effect of rutin enrichment was clearly seen in cakes obtained with dough fermentation step, even the inhibitory activity was slightly lower as compared to the cakes produced without dough fermentation.

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Diet‐Derived Advanced Glycation End Products Are Major Contributors to the Body's AGE Pool and Induce Inflammation in Healthy Subjects

Cited by 383 publications

References 18 publications

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

Skin Autofluorescence and All-Cause Mortality in Stage 3 CKD

Evaluation of the In Vitro Inhibitory Activity of Rye-Buckwheat Ginger Cakes with Rutin on the Formation of Advanced Glycation End-Products (AGEs)

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