Diet, Exercise and the Metabolic Syndrome

Pitsavos, Christos; Panagiotakos, Demosthenes B.; Weinem, Michael; Stefanadis, Christodoulos

doi:10.1900/rds.2006.3.118

Cited by 151 publications

(128 citation statements)

References 66 publications

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“…Several factors, including genetics, diet, lifestyle, and age, have been implicated in the development of NAFLD and associated metabolic disorders including diabetes, dyslipidemia, and cardiovascular disease (Pitsavos et al, 2006;. Recent studies also suggest exposure to environmental contaminants including persistent organic pollutants and organochlorines contributes to metabolic disease development (Cave et al, 2010;Lee et al, 2006Lee et al, , 2007Taylor et al, 2013).…”

mentioning

confidence: 99%

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis

et al. 2016

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Emerging evidence supports a role for environmental chemical exposure in the pathology of non-alcoholic fatty liver disease (NAFLD), a disease process tightly linked to increased activity of the blood coagulation cascade. Exposure of C57BL/6 mice to the persistent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) recapitulates features of the NAFLD spectrum, including steatosis, hepatic injury, inflammation, and fibrosis. We assessed coagulation cascade activation, and determined the role of the thrombin receptor protease activated receptor-1 (PAR-1) in experimental TCDDelicited NAFLD. Chronic exposure to TCDD (30 mg/kg every 4 days for 28 days) was associated with intrahepatic coagulation, indicated by increased plasma thrombin-antithrombin levels and hepatic fibrin(ogen) deposition. PAR-1 deficiency diminished TCDD-elicited body weight loss and relative liver weight was reduced in TCDD-exposed PAR-1 À/À mice compared with TCDD-exposed wild-type mice. PAR-1 deficiency did not affect TCDD-induced hepatic steatosis or hepatocellular injury, as indicated by serum alanine aminotransferase activity. Despite a lack of effect on these 2 features of NAFLD pathology, PAR-1 deficiency was associated with a reduction in hepatic inflammation evident in liver histopathology, and reflected by a reduction in serum levels of the proinflammatory cytokine interleukin-6. Moreover, TCDD-driven hepatic collagen deposition was markedly reduced in PAR-1-deficient mice. These results indicate that experimental TCDD-elicited steatohepatitis is associated with coagulation cascade activation and PAR-1-driven hepatic inflammation and fibrosis.

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mentioning

confidence: 99%

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis

et al. 2016

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“…To some extent, this is already done when an individual has been diagnosed with a particular diet‐related problem. For example, special diets are needed for people with inborn errors of protein metabolism such as phenylketonuria (PKU),58 and dietary changes are recommended for people with dyslipidaemia, hypertension or impaired glucose tolerance 59. Increasingly, however, it will be possible to personalize dietary advice according to dietary preferences, biological data and activity levels.…”

Section: Consumersmentioning

confidence: 99%

Healthy and sustainable diets for future generations

et al. 2018

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Global food systems will face unprecedented challenges in the coming years. They will need to meet the nutritional needs of a growing population and feed an expanding demand for proteins. This is against a backdrop of increasing environmental challenges (water resources, climate change, soil health) and the need to improve farming livelihoods. Collaborative efforts by a variety of stakeholders are needed to ensure that future generations have access to healthy and sustainable diets. Food will play an increasingly important role in the global discourse on health. These topics were explored during Nestlé's second international conference on ‘Planting Seeds for the Future of Food: The Agriculture, Nutrition and Sustainability Nexus’, which took place in July 2017. This article discusses some of the key issues from the perspective of three major stakeholder groups, namely farming/agriculture, the food industry and consumers. © 2018 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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“…A longo prazo, a AF com intensidade, duração e frequência suficientes tem um efeito favorável na redução do peso e distribuição da gordura corporal. A eficácia do exercício para induzir a perda de peso está diretamente relacionada ao grau inicial da obesidade e do gasto total de energia (PITSAVOS et al, 2006).…”

Section: Síndrome Metabólica E Atividade Físicaunclassified

Efeitos De Um Programa De Caminhada Supervisionada Na Qualidade De Vida De Indivíduos Com Síndrome Metabólica

Santos¹,

Silva

Silva³

2011

RevistaUnivap

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RESUMO: A realização de exercício físico regular é a terapia não-medicamentosa de primeira escolha para tratamento de indivíduos com Síndrome Metabólica (SM), ABSTRACT: Regular exercise is the first choice of a non-drug therapy to treat patients with metabolic syndrome, because it reduces weight, improves insulin sensitivity, decreases glucose levels, prevents the onset of diabetes, and improves the quality of life (QL). The aim of this study was to evaluate the benefits of a supervised walking program (SWP) on the QL of individuals with metabolic syndrome. Eight volunteers with metabolic syndrome (63 ± 9.65 years)

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Diet, Exercise and the Metabolic Syndrome

Cited by 151 publications

References 66 publications

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis

Healthy and sustainable diets for future generations

Efeitos De Um Programa De Caminhada Supervisionada Na Qualidade De Vida De Indivíduos Com Síndrome Metabólica

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