Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics

Li, Dan; Li, Yujuan; Yang, Shengjie; Lu, Jing; Jin, Xiao; Wu, Min

doi:10.1016/j.biopha.2022.113290

Cited by 75 publications

(42 citation statements)

References 194 publications

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“…McNabney and Henagan (2017) demonstrated that SCFAs are potential metabolic targets for preventing and counteracting obesity. Gut microbiota metabolizes flavonoids to produce SCFAs (Li et al, 2022). Therefore, diet-driven changes in the gut microbiota led to variations in SCFAs (Morrison and Preston, 2016).…”

Section: Discussionmentioning

confidence: 99%

Soybean isoflavones modulate gut microbiota to benefit the health weight and metabolism

Huang

Zheng

Hui

et al. 2022

Front. Cell. Infect. Microbiol.

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Soybean isoflavones (SIs) are widely found in food and herbal medicines. Although the pharmacological activities of SIs have been widely reported, their effects on the intestinal microecology of normal hosts have received little attention. Five-week-old Kunming (KM) mice were administered SIs (10 mg/kg/day) for 15 days. Food intake, body weight, and digestive enzyme activity were measured. Small intestine microbiota, including lumen-associated bacteria (LAB) and mucosa-associated bacteria (MAB), were analyzed using 16S ribosomal ribonucleic acid (16S rRNA) gene sequencing. Short-chain fatty acids (SCFAs) were analyzed using gas chromatography-mass spectrometry (GC-MS). The results showed that the mice that consuming SIs showed a higher food intake but a lower body weight gain rate than that of normal mice. Sucrase, cellulase, and amylase activities reduced, while protease activity increased after SIs intervention. Moreover, SIs increased the intestinal bacterial diversity in both LAB and MAB of normal mice. The composition of LAB was more sensitive to SIs than those of MAB. Lactobacillus, Adlercreutzia, Coprococcus, Ruminococcus, Butyricicoccus, and Desulfovibrio were the differential bacteria among the LAB of mice treated with SIs. In addition, acetic acid, valeric acid, isobutyric acid, isovaleric acid, and caproic acid decreased, while butyric acid and propionic acid increased in the mice treated with SIs. Taken together, SIs are beneficial for weight control, even in short-term interventions. The specific mechanism is related to regulating the gut microbiota, changing digestive enzyme activities, and further affecting carbohydrate absorption and metabolism.

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Section: Discussionmentioning

confidence: 99%

Soybean isoflavones modulate gut microbiota to benefit the health weight and metabolism

Huang

Zheng

Hui

et al. 2022

Front. Cell. Infect. Microbiol.

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“…First, a plant-based diet has a lower energy density, resulting in greater satiety with a lower energy consumption [18,32]. Furthermore, plant-based diets contain lower fat and higher ber which may impact the microbiome, which is known to have substantive impacts on energy utilization in humans [33][34][35]. However, the microbiome research has not progressed to the point that changes in the gut microbiome can be considered a cause or cure for excess body weight.…”

Section: Discussionmentioning

confidence: 99%

Plant-based and high protein diets are associated with a lower risk of obesity among Koreans at a high genetic risk of obesity.

Daily¹,

Park

2022

Preprint

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Background/Objectives: Obesity has become a severe public health challenge globally. The present study aimed to identify separate and interactive dietary, genetic, and other factors that increase the risk of obesity, as measured by body fat mass. Subjects/Methods: We utilized a genome-wide association study to identify genetic variants associated with high-fat mass(obesity; n=10,502) and combined them to generate polygenic risk scores(PRS) of genetic variants interacting with each other in adults aged over 40(n=58,701). We then evaluated dietary and lifestyle factors in subjects to assess what factors might help overcome a genetic propensity for higher body fat. Results: The three-SNP model included brain-derived neurotrophic factor(BDNF)_rs6265, fat mass and obesity-associated protein(FTO)_rs1421085, and SEC16B_rs509325. ADCY3_rs6545790 and BAIAP2_rs35867081 minor alleles increased their gene expression in the visceral and subcutaneous adipocytes, but ADCY3_rs6545790 and BAIAP2_rs35867081 minor alleles decreased their gene expression in the hypothalamus. In the three-SNP model, the PRS was associated with body fat mass by 1.408 and 1.396 times after adjusting covariates 1 and 2, respectively. However, when separating subjects by PRS of the three-SNP model, a plant-based diet was the most significant factor associated with low body fat, followed by high protein diets and lower energy intakes. They could offset the effects of high genetic risk for high body fat. Conclusions: Modulating nutrient intakes might overcome a high genetic risk for obesity. Dietary choices favoring more plant-based and higher protein foods might help prevent increased body fat in Asians and potentially people of other ethnicities with high polygenetic risk scores.

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“…Thus, low IgA levels at the intestinal surface barrier can also contribute to FA. In fact, gut microbiota can stimulate DCs in the Peyer’s patches to activate B cells, leading to specific IgA antibody production through class switching [ 213 , 214 ]. Follicular T cells also activate B cells, inducing the production of IgA antibodies.…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

Allergic Inflammation: Effect of Propolis and Its Flavonoids

Oršolić

2022

Molecules

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The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported.

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Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics

Cited by 75 publications

References 194 publications

Soybean isoflavones modulate gut microbiota to benefit the health weight and metabolism

Soybean isoflavones modulate gut microbiota to benefit the health weight and metabolism

Plant-based and high protein diets are associated with a lower risk of obesity among Koreans at a high genetic risk of obesity.

Allergic Inflammation: Effect of Propolis and Its Flavonoids

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