Diet in the Prevention of Alzheimer’s Disease: Current Knowledge and Future Research Requirements

Stefaniak, Oliwia; Dobrzyńska, Małgorzata; Drzymała-Czyż, Sławomira; Przysławski, Juliusz

doi:10.3390/nu14214564

Cited by 59 publications

(32 citation statements)

References 140 publications

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“…MD also contains many bioactive compounds, such as polyphenols ( 55 , 56 ), which present antioxidant activity ( 57 ). Moreover, consuming polyphenols improve epithelium cells' function and present an antioxidant effect ( 58 ).…”

Section: Mediterranean Lifestyle and Ibdmentioning

confidence: 99%

Should the Mediterranean diet be recommended for inflammatory bowel diseases patients? A narrative review

Ratajczak

Festa²,

Aratari³

et al. 2023

Front. Nutr.

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Inflammatory bowel diseases (IBD) are chronic, progressive and relapsing inflammatory disorders of unknown etiology that may cause disability over time. Data from epidemiologic studies indicate that diet may play a role in the risk of developing and the course of IBD. It is known that the group of beneficial bacteria was reduced in the IBD and that the Mediterranean diet (MD)—which is defined as eating habits characterized by high consumption of plant foods, mainly cereals, vegetables, fruit as well as olive oil, and small portions of dairy products, sweets, sugar and meat products—affects gut microbiota, enriching beneficial bacteria, which support gut barrier function and reduce inflammation. Although several studies support different favorable effects of MD on IBD, adherence to MD by IBD patients is generally low, including patients from the Mediterranean Basin. Patients avoid many products which are elements of MD because there cause gastrointestinal symptoms. Patients should be encouraged to have a healthy and well-balanced diet according to individual tolerance of products. A good option seems to be good modified MD, changing hard-to-digest products to easy digest.

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Section: Mediterranean Lifestyle and Ibdmentioning

confidence: 99%

Should the Mediterranean diet be recommended for inflammatory bowel diseases patients? A narrative review

Ratajczak

Festa²,

Aratari³

et al. 2023

Front. Nutr.

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“…Evidence is accumulating on the many diet components that might have a significant impact on the progression and prevention of AD (reviewed in [ 71 ]). As discussed, nuts are rich in compounds with anti-inflammatory, antioxidant, and hypolipidemic effects, thereby reducing the risk of CVD [ 16 ].…”

Section: Potential Mechanisms Of Action Of Nuts In Cognitive Healthmentioning

confidence: 99%

Impact of Nut Consumption on Cognition across the Lifespan

et al. 2023

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Cognitive health is a life-long concern affected by modifiable risk factors, including lifestyle choices, such as dietary intake, with serious implications for quality of life, morbidity, and mortality worldwide. In addition, nuts are a nutrient-dense food that contain a number of potentially neuroprotective components, including monounsaturated and polyunsaturated fatty acids, fiber, B-vitamins, non-sodium minerals, and highly bioactive polyphenols. However, increased nut consumption relates to a lower cardiovascular risk and a lower burden of cardiovascular risk factors that are shared with neurodegenerative disorders, which is why nuts have been hypothesized to be beneficial for brain health. The present narrative review discusses up-to-date epidemiological, clinical trial, and mechanistic evidence of the effect of exposure to nuts on cognitive performance. While limited and inconclusive, available evidence suggests a possible role for nuts in the maintenance of cognitive health and prevention of cognitive decline in individuals across the lifespan, particularly in older adults and those at higher risk. Walnuts, as a rich source of the plant-based polyunsaturated omega-3 fatty acid alpha-linolenic acid, are the nut type most promising for cognitive health. Given the limited definitive evidence available to date, especially regarding cognitive health biomarkers and hard outcomes, future studies are needed to better elucidate the impact of nuts on the maintenance of cognitive health, as well as the prevention and management of cognitive decline and dementia, including Alzheimer disease.

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“…Участие витамина К в метаболизме сфинголипидов известно уже несколько десятилетий. Однако недавно этот факт вновь привлек к себе повышенное внимание в связи с предполагаемыми эффектами метаболизма сфинголипидов на процесс старения и его участием в развитии нейродегенеративных расстройств, таких как болезни Альцгеймера и Паркинсона [26,28,29]. Было показано, что витамин К активирует 3-кето дигидро сфингозин (3-КДС) синтазу (также известную как серин-С-пальмитоилтрансфераза), которая является ферментом, участвующим в начальной стадии биосинтеза сфинголипидов [30], и сульфотрансферазу, ответственную за синтез сульфатидов.…”

Section: обзорыunclassified