Diet-Induced Prediabetes: Effects on Oxidative Stress and Inflammatory Biomarkers as Agents for Vascular Complications in Renal Function

Khathi, Andile; Luvuno, Mluleki; Mabandla, Musa V.

doi:10.21506/j.ponte.2019.2.9

Cited by 5 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, an inference can be made regarding the reduced creatinine levels, which form as a by-product of protein degradation in the prediabetic group, as the reduction in T4 would subsequently enhance the synthesis and degradation of proteins. A previously published study showed no significant changes in glomerular filtration during the prediabetic state, thus eliminating hyperfiltration as a possible cause for the reduction in creatinine levels [39]. The reduced plasma creatinine observed in the prediabetic group may therefore be an indicator of reduced protein synthesis, preceded by the reduction in thyroid hormone activity [40].…”

Section: Discussionmentioning

confidence: 91%

Association between Altered Thyroid Function and Prediabetes in Diet-Induced Prediabetic Male Sprague Dawley Rats

Pillay,

Mosili,

Akinnuga

et al. 2023

Diabetology

Self Cite

View full text Add to dashboard Cite

There is a correlation between the existence of type 2 diabetes mellitus (T2DM) and the development of thyroid disorders. Prediabetes is a progressive state of moderate insulin resistance that often precedes the onset of T2DM. However, the association between prediabetes and thyroid function is unknown. This study assessed changes in markers of thyroid function in diet-induced prediabetes. Twelve male Sprague Dawley rats (n = 12) were randomly assigned into two groups. Rats in the non-prediabetic (NPD) group were fed a standard rat diet, while rats in the prediabetic (PD) were fed a high-fat high-carbohydrate diet for 20 weeks to induce prediabetes. Thereafter, fasting blood glucose levels were measured. Plasma samples were assessed for triiodothyronine (T3), thyroxine (T4), thyroxine peroxidase (TPO) antibody, insulin, and glycated hemoglobin (HbA1c) concentrations. The elevated blood glucose, HbA1c, and plasma insulin levels coincided with increased T3 and reduced T4 levels in the PD group when compared to the NPD group. There was also an increase in the concentration of TPO antibodies in the PD group. Additionally, there was a significant correlation between the thyroid hormone concentrations and HbA1c levels. In conclusion, these results indicated that there is a positive association between thyroid dysfunction and diet-induced prediabetes in rats.

show abstract

Section: Discussionmentioning

confidence: 91%

Association between Altered Thyroid Function and Prediabetes in Diet-Induced Prediabetic Male Sprague Dawley Rats

Pillay,

Mosili,

Akinnuga

et al. 2023

Diabetology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our laboratory has established a pre-diabetic rat model that mimics the human condition. Using this model, we investigated changes in the activity of the cardiovascular system, the functioning of organs such as the kidney and liver, and physiological systems such as renin-angiotensin-aldosterone system in the pre-diabetic state 85–88. The HPA axis and immune systems have also been observed in the pre-diabetic state 89 90.…”

Section: Pre-diabetes: Can Moderate Hyperglycemia Have the Same Effec...mentioning

confidence: 99%

“…Using this model, we investigated changes in the activity of the cardiovascular system, the functioning of organs such as the kidney and liver, and physiological systems such as renin-angiotensin-aldosterone system in the prediabetic state. [85][86][87][88] The HPA axis and immune systems have also been observed in the pre-diabetic state. 89 90 In a study by Mosili and colleagues, hyperactivity of the HPA axis was observed in the pre-diabetic state.…”

Section: Effects Of Immune System Dysregulation Due To Hyperglycemia ...mentioning

confidence: 99%

Review of the direct and indirect effects of hyperglycemia on the HPA axis in T2DM and the co-occurrence of depression

Mosili,

Mkhize,

Sibiya

et al. 2024

BMJ Open Diab Res Care

Self Cite

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is characterized by persistent hyperglycemia which is further associated with hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Several studies have shown that HPA axis hyperactivity is heightened in the chronic hyperglycemic state with severe hyperglycemic events more likely to result in a depressive disorder. The HPA axis is also regulated by the immune system. Upon stress, under homeostatic conditions, the immune system is activated via the sympatho-adrenal-medullary axis resulting in an immune response which secretes proinflammatory cytokines. These cytokines aid in the activation of the HPA axis during stress. However, in T2DM, where there is persistent hyperglycemia, the immune system is dysregulated resulting in the elevated concentrations of these cytokines. The HPA axis, already activated by the hyperglycemia, is further activated by the cytokines which all contribute to a diagnosis of depression in patients with T2DM. However, the onset of T2DM is often preceded by pre-diabetes, a reversible state of moderate hyperglycemia and insulin resistance. Complications often seen in T2DM have been reported to begin in the pre-diabetic state. While the current management strategies have been shown to ameliorate the moderate hyperglycemic state and decrease the risk of developing T2DM, research is necessary for clinical studies to profile these direct effects of moderate hyperglycemia in pre-diabetes on the HPA axis and the indirect effects moderate hyperglycemia may have on the HPA axis by investigating the components of the immune system that play a role in regulating this pathway.

show abstract

“…More recently, studies in our laboratory using animal models have shown that complications often associated with T2D begin during the pre-diabetic state. [6][7][8][9][10][11] In these studies, it was shown that the presence of pre-diabetes could lead to compromised immunity. [6,7] These reports indicated that during the progression from pre-diabetes to overt T2D, there are changes in immune cell concentrations (neutrophils, lymphocytes, monocytes, eosinophils, basophils) and upregulation of inflammatory markers (C-reactive protein [CRP], tumour necrosis factor-alpha [TNF-α], Interleukin-6 [IL-6], P-Selectin, cluster of differentiation 40 ligands [CD40L], and Fibrinogen).…”

Section: Introductionmentioning

confidence: 99%

The changes that occur in the immune system during immune activation in pre-diabetic patients of all ethnicities, from the age of 25- to 45-years: A systematic review and meta-analysis

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background: Pre-diabetes is an intermediate state between normoglycaemia and type 2 diabetes (T2D). This condition has been shown to be asymptomatic thus making it hard to investigate the changes that occur in the body during this state. Recent findings stipulate that in this state, there are changes that are often associated with T2D. These include changes in concentration of immune cells and inflammatory markers. This systematic review will provide a synthesis of the data that is available reporting on the changes in the concentration of immune cells and selected markers during prediabetes. It will also give clarity of the variation of the complications of the condition among the various demographic groups. Methods: The assembly of this systematic review was through strict adherance to the PRISMA 2020 guidelines for reporting systematic reviews. This systematic review has been registered with the International Prospective Registry of Systematic Reviews (PROSPERO), registration number “CRD42020184828” dated 05-07-2020). In this systematic review, published clinical studies articles that involve observational reports, whether it is case-control, cross-sectional, and comparative cross-sectional will be used. Cohort study designs that involve normal/non-diabetic and pre-diabetes reports will be used in this systematic review and meta-analysis. Clinical MeSH headings to search on MEDLINE, COCHRANE library, EMBASE, and ICTRP and African Journal Online will be a tool used to achieve the required report. Reviewers (NCM, AMS, and AK) will screen all the results and select the studies that will be eligible by guidance according to eligibility criteria. Downs and Black Checklist will be used to check the risk of bias and then for meta-analysis Review Manager v5.4 Forrest plot will be used. Additionally, the Forrest plot will also be used for sensitivity analysis. The strength of evidence will then be assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Results: Only 4 reports were eligible and risk of bias checked. The results indicated the outcomes even though there were only few reports. Discussion and conclusion: This systematic review will give an indication on the available data on this research area and lay a foundation for future studies.

show abstract

Diet-Induced Prediabetes: Effects on Oxidative Stress and Inflammatory Biomarkers as Agents for Vascular Complications in Renal Function

Cited by 5 publications

References 0 publications

Association between Altered Thyroid Function and Prediabetes in Diet-Induced Prediabetic Male Sprague Dawley Rats

Association between Altered Thyroid Function and Prediabetes in Diet-Induced Prediabetic Male Sprague Dawley Rats

Review of the direct and indirect effects of hyperglycemia on the HPA axis in T2DM and the co-occurrence of depression

The changes that occur in the immune system during immune activation in pre-diabetic patients of all ethnicities, from the age of 25- to 45-years: A systematic review and meta-analysis

Contact Info

Product

Resources

About