Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment

Bayer-Carter, Jennifer L.; Green, Pattie S.; Montine, Thomas J.; VanFossen, Brian T.; Baker, Laura D.; Watson, G. Stennis; Bonner, Laura M.; Callaghan, Maureen; Leverenz, James B.; Walter, Brooke K.; Tsai, Elaine C.; Plymate, Stephen R.; Postupna, Nadia; Wilkinson, Charles W.; Zhang, Jing; Lampe, Johanna W.; Kahn, Steven E.; Craft, Suzanne

doi:10.1001/archneurol.2011.125

Cited by 134 publications

(121 citation statements)

References 58 publications

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“…glycemic diet was found to lower CSF insulin concentrations in healthy adults (96), corroborating the possibility that physiological mechanisms result in decreased brain insulin levels following peripheral hyperinsulinemia. Interestingly, impaired insulin sensitivity has been linked to cognitive deficits and structural and functional brain deficits in the elderly (97).…”

Section: Figurementioning

confidence: 54%

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

Felice¹

2013

J. Clin. Invest.

285

208

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Section: Figurementioning

confidence: 54%

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

Felice¹

2013

J. Clin. Invest.

285

208

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“…A 4-week RCT compared the effects of two different diets on insulin and lipid metabolism, cerebrospinal fluid markers of AD, and cognition in healthy subjects and subjects with amnestic MCI, aged on average 68 years (68) . The two diets were the high-saturated fat/high-glycaemic index (HIGH) diet (45 % fat with 25 % saturated fat, 35 -40 % carbohydrates with glycaemic index .…”

Section: Perspectives With a Priori Scores In Relationship With Cognimentioning

confidence: 99%

Dietary patterns: a novel approach to examine the link between nutrition and cognitive function in older individuals

et al. 2012

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Cognitive decline may lead to dementia whose most frequent cause is Alzheimer's disease (AD). Among the many potential risk factors of cognitive decline and AD, diet raises increasing interest. Most studies considered diet in the frame of a single nutrient approach with inconsistent results. A novel approach to examine the link between nutrition and cognitive function is the use of dietary patterns. The aim of the present review was to update and complete the body of knowledge about dietary patterns in relationship with various cognitive outcomes in the elderly. Two approaches can be used: a priori and a posteriori patterns. A priori patterns are defined by the adhesion to a predefined healthy diet using a score such as the Mediterranean diet (MeDi) score, the Healthy Eating Index, the Canadian Healthy Eating Index, the French National Nutrition and Health Programme (Programme National Nutrition Santé) Guideline Score (PNNS-GS), the Recommended Food Score (RFS) and Dietary Approaches to Stop Hypertension (DASH). MeDi score, RFS, PNNS-GS and DASH have been associated with lower risks of cognitive impairment, cognitive decline, and dementia or AD. Principal components analysis, reduced rank regression and clustering methods allow the identification of 'healthy' patterns associated with lower risk of cognitive decline. However, some studies did not report any associations with cognitive outcomes and results are discordant especially regarding MeDi and the risk of dementia. Several methodological challenges should be overcome to provide a higher level of evidence supporting the development of nutritional policies to prevent cognitive decline and AD.

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“…More recently, cerebrospinal fluid insulin levels were reported to be decreased in patients with mild AD [15]. Furthermore, a high saturated fat and high glycemic diet were found to lower cerebrospinal fluid insulin concentrations in healthy adults [16], corroborating the possibility that physiological mechanisms result in decreased brain insulin levels following peripheral hyperinsulinemia, a hallmark of Type 2 diabetes. Hyperinsulinemic/hyperglycemic individuals and mice show increased brain Ab levels [17][18][19], AD-associated toxins.…”

mentioning

confidence: 77%

Connecting Type 2 diabetes to Alzheimer’s disease

Felice

2013

Expert Review of Neurotherapeutics

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Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment

Cited by 134 publications

References 58 publications

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

Dietary patterns: a novel approach to examine the link between nutrition and cognitive function in older individuals

Connecting Type 2 diabetes to Alzheimer’s disease

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