Diet-Microbe-Host Interactions That Affect Gut Mucosal Integrity and Infection Resistance

Forgie, Andrew J.; Fouhse, Janelle M; Willing, Benjamin P.

doi:10.3389/fimmu.2019.01802

Cited by 61 publications

(43 citation statements)

References 173 publications

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“…Especially, species belonging to the phylum Proteobacteria are reported to increase epithelial cell death and mucus degradations [119]. Only some specialized bacteria such as; Clostridiaceae, Lactobacillaceae, Helicobacteraceae and Enterococcaceae are capable to adhere to mucus layer suggesting that these bacteria have a pivotal role in maintaining the gut intestinal barrier integrity [120][121][122]. Mucin degrading Akkermansia which have been previously shown to lower visceral fat deposits are associated with decreased body weight gain rate [123].…”

Section: Discussionmentioning

confidence: 99%

“…Mucin degrading Akkermansia which have been previously shown to lower visceral fat deposits are associated with decreased body weight gain rate [123]. Furthermore, the presence of mucin-degrading bacteria is associated with intestinal health, due to competitive exclusion of other bacteria which adhere less effectively to the mucosal surface [121,123]. Based on our data, the increase in the abundance of Akkermansia due to anthocyanins treatment decreased body weight moderately (TS6 2590 ± 280 g vs CS1 2758 ± 264 g) and FCR (TS6 1.36 ± 0.19 vs CS1 1.06 ± 0.3) in comparison to controls.…”

Section: Discussionmentioning

confidence: 99%

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Nutraceuticals Induced Structural Changes in Broiler Gastrointestinal Tract Microbiota

Tolnai¹,

Fauszt²,

Fidler³

et al. 2020

Preprint

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Background The effects of nutraceuticals on the modulation of the intestinal microbiota are receiving increased attention however there are scarce number of studies investigating their effects in broiler meat production. The aim of this study was to implement feeding strategies and carry out a comprehensive trial on the interplay between carotenoids, anthocyanins, fructo-oligosaccharides, probiotics and gastrointestinal tract microbiota. Our feeding program was applied on an intensive production system with 1080 broiler Ross 308 flock.Results We observed that nutraceuticals and synbiotics did not affect growth performance remarkably nevertheless, positive correlation was found between body weight and the beneficious Bacteroidales, Corynebacteriales and Pseudomonadales. Nutraceuticals were shown to boost broiler intestinal diversity and differentially enriched Lactobacillus, Enterococcus, Streptococcus and Escherichia-Shigella in core microbiome during the different stages of broiler rearing. Furthermore, diet supplemented with different nutraceuticals was shown to increase the number of unique beneficial bacteria (Faecalibacterium, Akkermansia).Conclusion We concluded that nutraceutical-based feeding strategies can offer a promising, green approach for intensive poultry rearing by improving the health and production of livestock. We believe that the conversion of food industrial waste would result more sustainable bioactive component rich forages which invention could be implemented by other commercial antibiotic-free animal production system providing safe and quality meat.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nutraceuticals Induced Structural Changes in Broiler Gastrointestinal Tract Microbiota

Tolnai¹,

Fauszt²,

Fidler³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…2). Dietary components play a major role in maintaining microbe-host interactions that may promote intestinal health [47]. Therefore, nutrition is an important tool that can be manipulated to restore beneficial microbe-host interactions that enhance intestinal integrity and health.…”

Section: The Diet-microbe Linkmentioning

confidence: 99%

The impact of maternal and early life malnutrition on health: a diet-microbe perspective

Forgie

Drall

Bourque

et al. 2020

BMC Med

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Background: Early-life malnutrition may have long-lasting effects on microbe-host interactions that affect health and disease susceptibility later in life. Diet quality and quantity in conjunction with toxin and pathogen exposure are key contributors to microbe-host physiology and malnutrition. Consequently, it is important to consider both diet-and microbe-induced pathologies as well as their interactions underlying malnutrition. Main Body: Gastrointestinal immunity and digestive function are vital to maintain a symbiotic relationship between the host and microbiota. Childhood malnutrition can be impacted by numerous factors including gestational malnutrition, early life antibiotic use, psychological stress, food allergy, hygiene, and exposure to other chemicals and pollutants. These factors can contribute to reoccurring environmental enteropathy, a condition characterized by the expansion of commensal pathobionts and environmental pathogens. Reoccurring intestinal dysfunction, particularly during the critical window of development, may be a consequence of diet-microbe interactions and may lead to lifelong immune and metabolic programming and increased disease risk. We provide an overview of the some key factors implicated in the progression of malnutrition (protein, fat, carbohydrate, iron, vitamin D, and vitamin B12) and discuss the microbiota during early life that may contribute health risk later in life. Conclusion: Identifying key microbe-host interactions, particularly those associated with diet and malnutrition requires well-controlled dietary studies. Furthering our understanding of diet-microbe-host interactions will help to provide better strategies during gestation and early life to promote health later in life.

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“…The damage of gut barrier integrity has been regarded as a fundamental factor in the pathogenesis of many gut-derived diseases, such as inammatory bowel diseases and MS. 28 Researches have demonstrated the importance of a consecutive and functional barrier in maintaining intestinal homeostasis and preventing diseases. [29][30][31] Thus, a BEB that could spread on the intestine with functional properties against pathogens could enhance the barrier function and contribute to many diseases.…”

Section: Characterizing the Beb Microcapsulementioning

confidence: 99%

Biomimetic enzyme barrier for preventing intestine-derived LPS induced diseases

et al. 2020

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Biomimetic enzyme barrier (BEB) encapsulated microcapsules with alginate shells were in situ fabricated with a microfluidic electrospray approach for preventing intestine-derived LPS induced diseases. As the alginate shells could protect the contents in gastric juice and release them in the intestine, the inner BEB could form a consecutive immune barrier on the surface of the intestine during the release. Through combining BEB with alkaline phosphatase, the immune barrier could degrade and prevent the permeation of lipopolysaccharide, which enhanced the intestinal barrier function. Thus, the BEB microcapsules were imparted with outstanding ability in preventing intestine-derived LPS induced diseases. Based on an in vivo study, we demonstrated that this BEB microcapsule could effectively protect organ function, restore intestinal barrier integrity, prevent the permeation of LPS and alleviate inflammation. Therefore, the generated microcapsules have potential for clinical applications.

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Diet-Microbe-Host Interactions That Affect Gut Mucosal Integrity and Infection Resistance

Cited by 61 publications

References 173 publications

Nutraceuticals Induced Structural Changes in Broiler Gastrointestinal Tract Microbiota

Nutraceuticals Induced Structural Changes in Broiler Gastrointestinal Tract Microbiota

The impact of maternal and early life malnutrition on health: a diet-microbe perspective

Biomimetic enzyme barrier for preventing intestine-derived LPS induced diseases

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