Diet‐microbiota crosstalk and immunity to helminth infection

Myhill, Laura J.; Williams, Andrew R.

doi:10.1111/pim.12965

Cited by 2 publications

(2 citation statements)

References 105 publications

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“…However, secondary metabolites of indigo could positively affect the gut microbiome, alleviating symptoms of inflammatory bowel disease [ 36 ] or by influencing senescence processes [ 37 ]. On the other hand, an extract of sainfoin exhibited a general positive influence on gut microbial communities [ 38 ], and resulted helpful also for feeding, for example as an anti-helmintic [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

In Vitro Prebiotic Effects and Antibacterial Activity of Five Leguminous Honeys

Fratianni,

De Giulio,

d’Acierno

et al. 2023

Foods

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Honey is a natural remedy for various health conditions. It exhibits a prebiotic effect on the gut microbiome, including lactobacilli, essential for maintaining gut health and regulating the im-mune system. In addition, monofloral honey can show peculiar therapeutic properties. We in-vestigated some legumes honey’s prebiotic properties and potential antimicrobial action against different pathogens. We assessed the prebiotic potentiality of honey by evaluating the antioxidant activity, the growth, and the in vitro adhesion of Lacticaseibacillus casei, Lactobacillus gasseri, Lacticaseibacillus paracasei subsp. paracasei, Lactiplantibacillus plantarum, and Lacticaseibacillus rhamnosus intact cells. We also tested the honey’s capacity to inhibit or limit the biofilm produced by five pathogenic strains. Finally, we assessed the anti-biofilm activity of the growth medium of probiotics cultured with honey as an energy source. Most probiotics increased their growth or the in vitro adhesion ability to 84.13% and 48.67%, respectively. Overall, alfalfa honey best influenced the probiotic strains’ growth and in vitro adhesion properties. Their radical-scavenging activity arrived at 83.7%. All types of honey increased the antioxidant activity of the probiotic cells, except for the less sensitive L. plantarum. Except for a few cases, we observed a bio-film-inhibitory action of all legumes’ honey, with percentages up to 81.71%. Carob honey was the most effective in inhibiting the biofilm of Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, and Staphylococcus aureus; it retained almost entirely the ability to act against the bio-film of E. coli, L. monocytogenes, and S. aureus also when added to the bacterial growth medium instead of glucose. On the other hand, alfalfa and astragalus honey exhibited greater efficacy in acting against the biofilm of Acinetobacter baumannii. Indigo honey, whose biofilm-inhibitory action was fragile per se, was very effective when we added it to the culture broth of L. casei, whose supernatant exhibited an anti-biofilm activity against all the pathogenic strains tested. Conclusions: the five kinds of honey in different ways can improve some prebiotic properties and have an inhibitory biofilm effect when consumed.

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Section: Resultsmentioning

confidence: 99%

In Vitro Prebiotic Effects and Antibacterial Activity of Five Leguminous Honeys

Fratianni,

De Giulio,

d’Acierno

et al. 2023

Foods

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“…It has been proposed that communication between infecting nematodes and gut microflora is facilitated by helminth derived extracellular vesicles (EVs) that contain immunomodulatory factors, such as transforming growth factor β (TGF-β) and peroxiredoxins, that induce responses to infection and regulate anthelmintic type-2 responses [33]. EVs have also been implicated in parasite migration during changing larval stages and for nutrition, and their presence in the gut can affect a number of beneficial commensals such as probiotics [174]. A deeper understanding of how parasite mucosal vaccines are affected by changes to the microbiome could help develop new vaccine antigens and increase the efficiency of vaccine delivery in the host.…”

Section: Parasite Immune Modulation Of the Host Mucosal Microenvironmentmentioning

confidence: 99%

Mucosal Immunity of Major Gastrointestinal Nematode Infections in Small Ruminants Can Be Harnessed to Develop New Prevention Strategies

Palkumbura,

Mahakapuge,

Wijesundera

et al. 2024

IJMS

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Gastrointestinal parasitic nematode (GIN) infections are the cause of severe losses to farmers in countries where small ruminants such as sheep and goat are the mainstay of livestock holdings. There is a need to develop effective and easy-to-administer anti-parasite vaccines in areas where anthelmintic resistance is rapidly rising due to the inefficient use of drugs currently available. In this review, we describe the most prevalent and economically significant group of GIN infections that infect small ruminants and the immune responses that occur in the host during infection with an emphasis on mucosal immunity. Furthermore, we outline the different prevention strategies that exist with a focus on whole and purified native parasite antigens as vaccine candidates and their possible oral–nasal administration as a part of an integrated parasite control toolbox in areas where drug resistance is on the rise.

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Diet‐microbiota crosstalk and immunity to helminth infection

Cited by 2 publications

References 105 publications

In Vitro Prebiotic Effects and Antibacterial Activity of Five Leguminous Honeys

In Vitro Prebiotic Effects and Antibacterial Activity of Five Leguminous Honeys

Mucosal Immunity of Major Gastrointestinal Nematode Infections in Small Ruminants Can Be Harnessed to Develop New Prevention Strategies

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