Diet Quality And Inflammatory Index Score Among Women’s Cancer Survivors

Abstract

Despite the known benefits of exercise training in reducing the hyperglycemic state and the harmful effects of Diabetes Mellitus on skeletal muscle health, the optimal exercise intensity to elicit maximal outcomes is still under debate. PURPOSE: To compare the effects of moderate-intensity training (MIT) with those of high intensity interval training (HIIT) sessions on glycemia and changes in GSH antioxidant system in slow-twitch and fast-twitch muscles of streptozotocin-induced diabetic rats. METHODS: Male Wistar rats (30 days old) were randomly divided into four groups: control (C), sedentary diabetic (SD), diabetic with HIIT (HIIT) and diabetic with MIT (MIT). Diabetes was induced by a single streptozotocin injection (100 mg/kg body weight), animals with fasting blood glucose levels ≥ 300 mg/dL were considered as diabetic. Exercise training programs were performed on a treadmill (30 minutes daily, 5 days/week) for 8 weeks. At the end of the intervention, extensor digitorum longus (EDL) muscle (fast-twitch) and soleus (slow-twitch) muscles were dissected and the concentration of reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio were determined. RESULTS: Exercise with MIT, but not HIIT, reduces blood glucose levels by 30.18% (p=0.001) compared to DS group. In diabetes, GSH concentrations were significantly lower in both muscles compared to C group. Both MIT and HIIT induced significant changes by increasing the total glutathione levels (GSH+GSSG) in slow (32.33% and 25.37%, respectively) and fast (188.15% and 156.38%, respectively) muscles compared SD group. However, only HIIT increases the GSH/GSSG ratio in slow muscle (107.36%), instead the MIT promoted greater benefits on fast muscles (55.89%) compared to SD group. CONCLUSIONS: Both exercise protocols have positive effects on GSH antioxidant system in slow-twitch and fast-twitch muscles, however, MIT appeared most effective to reduce diabetesrelated hyperglycemia.