Diet, vegetarian food and prostate carcinoma among men in Taiwan

Yc, Chen; Ci, Chiang; Lin, Ren; Pu, Yeong-Shiau; Mk, Lai; Fc, Sung

doi:10.1038/sj.bjc.6602809

Cited by 46 publications

(53 citation statements)

References 27 publications

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“…A despeito dos questionamentos dos efeitos adversos do consumo de soja transgênica, deve-se considerar também que essa leguminosa, na sua forma convencional, tem sido amplamente apontada como agente de prevenção ao câncer (CHEN et al, 2005;GUTIERREZ et al, 2005;INAGAKI et al, 2005). Importantes efeitos biológicos têm sido atribuídos às isoflavonas, como atividade antioxidante (ESAKI et al, 1999;NAIM et al, 1976), antiaterogênica (HUI et al, 2001), hipocolesterolêmica (LUI et al, 2003), propriedades estrogênicas (PARK et al, 2001), além do potencial anticarcinogênico (COWARD et al, 1993) e inibição da atividade enzimática (ESTEVES; MONTEIRO, 2001).…”

Section: Introductionunclassified

Soja transgênica BRS 243 RR: determinação de macronutrientes e das isoflavonas daidzeína e genisteína por Cromatografia Líquida de Alta Eficiência (CLAE)

Alezandro¹,

Almeida²,

Maia³

et al. 2008

Ciênc. Tecnol. Aliment.

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The objective of this work was to evaluate the proximate composition, as well as Daidzein (D) and Genistein (G) contents by HPLC, of BRS 243 RR soybean. Sample preparation for the chromatographic analysis involved the use of hexane to remove lipids. Isoflavones were extracted with 70% ethanol containing 0.1% acetic acid. The optimized chromatographic conditions were: C 18 column, mobile phase methanol:5% acetic acid (1:1 v/v), flow rate 0.5 mL/minute, column temperature 30 °C, UV absorbance at 254 nm and volume injected 40 µL. The validation parameters were: linearity of daidzein (y = 11242 x -37433, r = 0.9976) and genistein (y = 18510 x -66761, r = 0.9980); variation coefficients obtained in intra-day precision assays [CV = 5.3% (D), CV = 6.7% (G)] and inter-day precision assays [CV = 8.7% (D), CV = 9.7% (G)]; quantification limit 10 µg.g ResumoEste trabalho teve por objetivo determinar a composição centesimal e o conteúdo de Daidzeína (D) e Genisteína (G) da cultivar BRS 243 RR por CLAE. O preparo da amostra para cromatografia envolveu a remoção da gordura com hexano . Os analitos foram extraídos com etanol 70% acrescido de 0,1% de ácido acético. As condições cromatográficas otimizadas foram: coluna C 18 , fase móvel metanol: ácido acético 5% IntroduçãoNo Brasil, o alimento geneticamente modificado de maior produção é a soja, sendo que a oferta de suas sementes no mercado nacional é da ordem de 60%. A versatilidade dos grãos de soja dá origem a produtos e subprodutos muito utilizados na agroindústria, na indústria química e na de alimentos, o que determina o seu grande consumo por parte da população .A despeito dos questionamentos dos efeitos adversos do consumo de soja transgênica, deve-se considerar também que essa leguminosa, na sua forma convencional, tem sido amplamente apontada como agente de prevenção ao câncer (CHEN et al., 2005;GUTIERREZ et al., 2005;INAGAKI et al., 2005). Importantes efeitos biológicos têm sido atribuídos às isoflavonas, como atividade antioxidante (ESAKI et al., 1999;NAIM et al., 1976), antiaterogênica (HUI et al., 2001), hipocolesterolêmica (LUI et al., 2003), propriedades estrogênicas (PARK et al., 2001), além do potencial anticarcinogênico (COWARD et al., 1993) e inibição da atividade enzimática (ESTEVES; MONTEIRO,

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Section: Introductionunclassified

Soja transgênica BRS 243 RR: determinação de macronutrientes e das isoflavonas daidzeína e genisteína por Cromatografia Líquida de Alta Eficiência (CLAE)

Alezandro¹,

Almeida²,

Maia³

et al. 2008

Ciênc. Tecnol. Aliment.

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“…It is believed that a reduction in fat consumption would result in reduction in prostate cancer incidence. 47,48 Figure 1 Citrate metabolism and fatty acid pathway. Fats are broken down to fatty acids and glycerol.…”

Section: Diet Fat and Prostate Cancermentioning

confidence: 99%

Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer

Liu¹

2006

Prostate Cancer Prostatic Dis

385

311

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Most malignancies have increased glycolysis for energy requirement of rapid cell proliferation, which is the basis for tumor imaging through glucose analog FDG (2-deoxy-2-fluoro-D-glucose) with positron emission tomography. One of significant characteristics of prostate cancer is slow glycolysis and low FDG avidity. Recent studies showed that prostate cancer is associated with changes of fatty acid metabolism. Several enzymes involved in the metabolism of fatty acids have been determined to be altered in prostate cancer relative to normal prostate, which is indicative of an enhanced b-oxidation pathway in prostate cancer. Increased fatty acid utilization in prostate cancer provides both ATP and acetyl-coenzyme A (CoA); subsequently, increased availability of acetyl-CoA makes acceleration of citrate oxidation possible, which is an important energy source as well. Dominant fatty acid metabolism rather than glycolysis has the potential to be the basis for imaging diagnosis and targeted treatment of prostate cancer.

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“…Based on data from 11 case-cohort studies (La Vecchia et al, 1991;Ewings et al, 1996;Gronberg et al, 1996;Jain et al, 1999;Sung et al, 1999;Bosetti et al, 2004;Sonoda et al, 2004;Chen et al, 2005;Ukoli et al, 2009;Tyagi et al, 2010;Deneo-Pellegrini et al, 2012), we found no association between high intake of eggs and risk of prostate cancer (OR 1.09, 95% CI 0.89-1.31) (Figure 2). There was a significant heterogeneity between studies (p = 0.022, I 2 = 52.2%).…”

Section: Case-control Studiesmentioning

confidence: 99%

“…Of all studies reviewed, three cohort studies presented RR estimates for fatal prostate cancer (Snowdon et al, 1984;Hsing et al, 1990;Richman et al, 2011). Seven studies were conducted in US/Canada (Snowdon et al, 1984;Mills et al, 1989;Severson et al, 1989;Hsing et al, 1990;Le Marchand et al, 1994;Jain et al, 1999;Richman et al, 2011), six in Europe (La Vecchia et al, 1991;Ewings et al, 1996;Gronberg et al, 1996;Schuurman et al, 1999;Bosetti et al, 2004;Allen et al, 2008), five in Asia (Sung et al, 1999;Allen et al, 2004;Sonoda et al, 2004;Chen et al, 2005;Tyagi et al, 2010), one in Negeria (Ukoli et al, 2009) and one in Uruguay (Deneo-Pellegrini et al, 2012). Overall, this meta-analysis included 5791 cases of prostate cancer, and most studies suggested a non-significant relationship between eggs consumption and prostate cancer.…”

Section: Figure 1 Flowchart Of Study Searchmentioning

confidence: 99%

“…One case-control study published partly duplicated data in three different articles, and we selected the recent one with largest sample size (Deneo-Pellegrini et al, 2012). Finally, the remaining 20 publications were retained for the meta-analysis (Snowdon et al, 1984;Mills et al, 1989;Severson et al, 1989;Hsing et al, 1990;La Vecchia et al, 1991;Le Marchand et al, 1994;Ewings et al, 1996;Gronberg et al, 1996;Jain et al, 1999;Schuurman et al, 1999;Sung et al, 1999;Allen et al, 2004;Bosetti et al, 2004;Sonoda et al, 2004;Chen et al, 2005;Allen et al, 2008;Ukoli et al, 2009;Tyagi et al, 2010;Richman et al, 2011;Deneo-Pellegrini et al, 2012).…”

Section: Figure 1 Flowchart Of Study Searchmentioning

confidence: 99%

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No Association between Egg Intake and Prostate Cancer Risk: A Meta-analysis

Xie¹,

He²

2012

Asian Pacific Journal of Cancer Prevention

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Asian Pacific J Cancer Prev, 13 (9), 4677-4681 IntroductionProstate cancer is the most common cancer among men in United States. It is also one of the leading causes of cancer death among men of all races (Siegel et al., 2012). Although age and family history have been established as strong risk factors for prostate cancer, the role of individual dietary factors is not well understood. The large variation in incidence across countries may also suggest the role of lifestyle and dietary factors in its cause (Yu et al., 1991). Eggs are frequently consumed worldwide, supply substantial portions of protein, fat, retinal, riboflavin and iron. Eggs are also unique among foods, given their relatively high content of several substances, such as cholesterol, choline, biotin, and avidin. There is evidence pointing to a possible role of eggs consumption on cancer etiology. A positive association has been observed between eggs consumption and risk of colorectal cancer (Steinmetz et al., 1994). For other cancer sites, there is no established association with eggs. Several studies considered the relation between eggs intake and prostate cancer. Though most of them reported no association, results were often inconsistent. With the aim to investigate the relationship between prostate cancer and eggs consumption, we carried out a meta-analysis of epidemiological studies published up to July 2012. Materials and MethodsA systematic literature search was carried out in the AbstractObjective: Egg consumption has been suggested to increase the risk of colorectal and some other cancers. The present study summarized and quantified the current evidence relating dietary intake of eggs and prostate cancer. Materials and methods: Literature searches were conducted to identify peer-reviewed manuscripts published up to July 2012. Twenty manuscripts from nine cohort studies and 11 case-control studies were identified. Summary risk estimates with 95% confidence intervals (CIs) were calculated for case-control and cohort studies separately. Results: Neither the case-control not the cohort studies showed any association of prostate cancer incidence with egg consumption (case-control studies: odds ratio 1.09, 95% CI 0.86-1.31; cohort studies: relative risk 0.97, 95% CI 0.97-1.07). The results were consistent in subgroup analysis. Furthermore, no association was observed between egg consumption and prostate cancer-specific mortality. Conclusions: Our analyses provided no evidence of a significant influence of egg consumption on prostate cancer incidence and mortality. However, more studies, particularly large prospective studies, are needed.

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Diet, vegetarian food and prostate carcinoma among men in Taiwan

Cited by 46 publications

References 27 publications

Soja transgênica BRS 243 RR: determinação de macronutrientes e das isoflavonas daidzeína e genisteína por Cromatografia Líquida de Alta Eficiência (CLAE)

Soja transgênica BRS 243 RR: determinação de macronutrientes e das isoflavonas daidzeína e genisteína por Cromatografia Líquida de Alta Eficiência (CLAE)

Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer

No Association between Egg Intake and Prostate Cancer Risk: A Meta-analysis

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