Diet, weight status, and physical activity in cancer prevention

Abstract

Background: Cancer is a multifactorial disease involving individual, behavioral and environmental factors that can contribute to its onset. More than 40% of cancers are estimated to be attributable to avoidable risk factors, particularly diet, physical activity, weight status, and alcohol consumption. Aim: To provide insight into the role of weight status, diet, and physical activity in cancer causation and prevention, and to highlight evidence-based recommendations. Material and methods: A literature review of published studies, particularly recent systematic reviews, meta-analyses, and large prospective studies was conducted using PubMed/Medline, ScienceDirect, and Google Scholar databases. Results: There is evidence that diets high in red and processed meats, fat and refined carbohydrates, and low in plant foods such as vegetables, fruits, and whole grains, high consumption of alcohol, overweight/obesity, and physical inactivity are associated with increased risk of tumor development and progression. Therefore, the current recommendations for cancer prevention are based on: (1) eating at least five portions (400g) of vegetables (3 portions) and fruits (2 portions); (2) limiting the consumption of alcohol and unhealthy foods such as red and processed meats, energy-dense foods, and trans-fatty acids; (3) maintaining a healthy weight status; and (4) being at least moderately physically active. Conclusion: While a balanced diet, as defined by the recommendations, can help reduce the risk of certain cancers, no single food can prevent the development of this pathology. The term "anticancer" associated with diet is therefore misleading. Several nutritional factors are associated with an increase or a decrease in the risk of certain cancers. Adopting a healthy and plant-based diets, avoiding overweight/obesity, and being physically active are considered as cornerstones of preventive strategies against cancer. Further studies are needed to elucidate the associations between dietary and lifestyle patterns and cancer. ​Keywords: Cancer, Diet, Weight status, Overweight, Obesity, Physical activity.

Feasibility and Acceptability Evaluation of a Digital Therapeutic Program for Improving Cancer Prevention: A Pre-Post Interventional Study

“…Projections suggest that by 2030, cancer will a ict more than 22 million people globally, causing over 17 million fatalities [1,2]. Lifestyle factors such as tobacco and alcohol consumption [3,4], inadequate sleep [5][6][7][8], heightened stress [9][10][11][12][13][14][15][16], sedentary living [17,18], and poor dietary choices [19] signi cantly elevate cancer risk. In fact, it is estimated that over half of all cancer cases stem from unhealthy individual behavioral choices [20].…”

“…Hence, modifying our lifestyle habits presents an effective strategy for cancer prevention. However, our susceptibility to habits like smoking, excessive drinking, inadequate sleep, and unhealthy eating poses a challenge, fostering irregular and unhealthy behaviors that contribute to cancer onset [17,22,23].…”