Diet with high content of advanced glycation end products induces systemic inflammation and weight gain in experimental mice: Protective role of curcumin and gallic acid

Rajan, Boopathi Sowndhar; Manivasagam, Senthamizharasi; Dhanusu, Suresh; Chandrasekar, Navvi; Krishna, K.R. Sudarshana; Kalaiarasu, Lakshmi Priya; Babu, Aadhil Ashwaq; Vellaichamy, Elangovan

doi:10.1016/j.fct.2018.02.016

Cited by 37 publications

(28 citation statements)

References 57 publications

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“…In fact, iron overload might interact with AGEs in the development of cognitive alterations, with AGEs specifically triggering inflammation . Mice fed a diet with high AGEs developed systemic inflammation as compared with those fed a control diet . Of note, in this study we found that hsCRP was independently associated with CVLT scores and brain iron content.…”

Section: Discussionmentioning

confidence: 47%

Glycated Hemoglobin, but not Insulin Sensitivity, is Associated with Memory in Subjects with Obesity

Arnoriaga-Rodríguez

Blasco

Coll

et al. 2019

Obesity

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Objective: Obesity has been related to later-life dementia. Serum glucose levels and insulin resistance are known to influence cognition in individuals with diabetes. This study aimed to evaluate memory function in middle-aged individuals with obesity in association with glucose metabolism and brain iron content. Methods: This was a cross-sectional case-control study including 121 participants aged 27.2 to 66.6 years (56 without obesity, 65 with obesity) stratified according to sex and menopausal status. Insulin sensitivity, body composition, brain iron content, and memory function were evaluated by euglycemic hyperinsulinemic clamp, dual-energy x-ray absorptiometry, magnetic resonance relaxometry (R2*), and California Verbal Learning Test, respectively. Results: Women with obesity, but not men, had lower scores in some California Verbal Learning Tests in association with metabolic parameters and increased brain iron content compared with controls. Fasting plasma glucose, glycated hemoglobin (HbA1c; within normal range), and R2* were negatively associated with memory scores, whereas insulin sensitivity showed positive associations. Remarkably, only HbA1c levels and R2* in the right inferior fronto-orbital region remained significant after controlling for age, sex, education, and BMI. Conclusions: Impairments in memory function in middle-aged women with obesity are associated with HbA1c levels and brain iron content independently of insulin sensitivity. These results may have implications in the design of therapeutic strategies in women with obesity.Obesity (2019) 27, 932-942.

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Section: Discussionmentioning

confidence: 47%

Glycated Hemoglobin, but not Insulin Sensitivity, is Associated with Memory in Subjects with Obesity

Arnoriaga-Rodríguez

Blasco

Coll

et al. 2019

Obesity

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“…In addition, an HFD may enhance endogenous AGE formation [55,56]. An animal study showed that an HFD induced visceral AGE formation [55], and mice fed high dietary AGEs exhibited increased systemic inflammatory cytokines and weight gain [57]. An in vitro study showed that AGEs suppressed human chorionic gonadotropin-induced T synthesis in a dose-dependent manner in primary rat Leydig's cells via inducing oxidative stress and endoplasmic reticular stress-associated pathways [21].…”

Section: Discussionmentioning

confidence: 99%

Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity

et al. 2020

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The literature suggests a bidirectional relationship between testosterone (T) and iron, but mechanisms underlying this relationship remain unclear. We investigated effects of iron on advanced glycation end products (AGEs) in obesity-related androgen deficiency. In total, 111 men were recruited, and iron biomarkers and N(ɛ)-(carboxymethyl)lysine (CML) were measured. In an animal study, rats were fed a 50% high-fat diet (HFD) with (0.25, 1, and 2 g ferric iron/kg diet) or without ferric citrate for 12 weeks. Obese rats supplemented with >1 g iron/kg diet had decreased testicular total T compared to HFD alone. Immunohistochemical staining showed that >1 g of ferric iron increased iron and AGE retention in testicular interstitial tissues, which is associated with increased expression of the receptor for AGEs (RAGE), tumor necrosis factor-α, and nitric oxide. Compared with normal weight, overweight/obese men had lower T levels and higher rates of hypogonadism (19% vs. 11.3%) and iron overload (29.8% vs.15.9%). A correlation analysis showed serum total T was positively correlated with transferrin saturation (r = 0.242, p = 0.007) and cathepsin D (r = 0.330, p = 0.001), but negatively correlated with red blood cell aggregation (r = −0.419, p<0.0001) and CML (r = −0.209, p < 0.05). In conclusion, AGEs may partially explain the underlying relationship between dysregulated iron and T deficiency.

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“…Polysaccharide nanofibers improved GA and EGCG permeability by opening the tight junctions of human differentiated epithelial Caco-2 cell monolayers and inhibiting efflux transporters (141). Cotreatment with curcumin and GA normalized the circulatory pro-inflammatory, anti-inflammatory cytokines, chemokines, N-εCML, CRP, and HbA1c (142). In addition, The GA derivatives (G-4, G-7, G-9, G-10, G-12, and G-13) also exhibited immunomodulatory activity and had high binding affinities for the INFα-2, IL-6, and IL-4 receptors, among which G-7 has the greatest immunomodulatory activity (143).…”

Section: Ga In Immunomodulationmentioning

confidence: 98%

Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

et al. 2020

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Gallic acid (GA) is a naturally occurring polyphenol compound present in fruits, vegetables, and herbal medicines. According to previous studies, GA has many biological properties, including antioxidant, anticancer, anti-inflammatory, and antimicrobial properties. GA and its derivatives have multiple industrial uses, such as food supplements or additives. Additionally, recent studies have shown that GA and its derivatives not only enhance gut microbiome (GM) activities, but also modulate immune responses. Thus, GA has great potential to facilitate natural defense against microbial infections and modulate the immune response. However, the exact mechanisms of GA acts on the GM and immune system remain unclear. In this review, first the physicochemical properties, bioavailability, absorption, and metabolism of GA are introduced, and then we summarize recent findings concerning its roles in gastrointestinal health. Furthermore, the present review attempts to explain how GA influences the GM and modulates the immune response to maintain intestinal health.

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Diet with high content of advanced glycation end products induces systemic inflammation and weight gain in experimental mice: Protective role of curcumin and gallic acid

Cited by 37 publications

References 57 publications

Glycated Hemoglobin, but not Insulin Sensitivity, is Associated with Memory in Subjects with Obesity

Glycated Hemoglobin, but not Insulin Sensitivity, is Associated with Memory in Subjects with Obesity

Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity

Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

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