Dieta y prevención en enfermedad de Alzheimer

Arizaga, Raúl Luciano; Barreto, Dolores; Bavec, Claudia Verónica; Berrios, Waleska; Cristalli, Diana; Colli, Liliana Patricia; Garau, Mariela; Golimstok, Ángel; Ollari, Juan; Sarasola, Diego

doi:10.1016/j.neuarg.2017.11.002

Cited by 3 publications

(7 citation statements)

References 174 publications

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“…Some of the more usual clinical features include cognitive impairment, memory loss, language disorders, sudden changes of mood and behavior, and disorientation in time and space, hampering the patient’s ability to perform normal daily activities [6,7]. It typically lasts around 10–12 years, but there is remarkable interindividual variability [8].…”

Section: Alzheimer’s Diseasementioning

confidence: 99%

“…Belonging to the ω3 series, DHA also decreases the activity of the secretases of the amyloidogenic route and indirectly potentiates the non-amyloidogenic one. On top of these observations, the MD is related to moderate consumption of red wine, usually during meals, with a positive effect due to its polyphenols [8,14,34], while also containing ethanol, which might help preserve cerebrovascular function [47].…”

Section: Relevance Of Dietary Patternsmentioning

confidence: 99%

“…In addition, some dietary patterns may affect AD risk and development indirectly, through modulation of some AD risk factors. For instance, obesity, type 2 diabetes, or cardiovascular disease have been established to increase the risk of developing AD [8,15,39,50] and certain dietary and lifestyle interventions have been proven to prevent or alleviate the impact of these conditions in health. Thus, this improvement may translate as a diminished risk of developing AD or another type of dementia [51].…”

Section: Relevance Of Dietary Patternsmentioning

confidence: 99%

“…On the other hand, if homocysteine accumulation reaches concentrations higher than 15 µmol/L, it is considered hyperhomocysteinemia. This situation produces both a greater cognitive impairment and an increase of vascular dysfunction associated with dementia, due to atherogenic and prothrombotic properties, thus constituting a risk factor for cardiovascular disease with possible relevance in AD [8,15]. To evaluate this hypothesis, a study was conducted in AD patients with low levels of folic acid and vitamin B12, but elevated homocysteine.…”

Section: Nutrients That Modulate Alzheimer’s Diseasementioning

confidence: 99%

“…Some authors propose vitamin B12, B9, or B6 supplementation as a means to reduce homocysteine levels, based on the role they play in its metabolism [8,103]. This accords with previous results showing that female transgenic mice model of AD Tg2576 overexpressing the human APP with the Swedish mutation (K670N/M671L) that were fed a diet low in folic acid (<0.2 mg/kg), vitamin B12 (<0.001 mg/kg), and vitamin B6 (<0.1 mg/kg) displayed hyperhomocysteinemia, which caused an increase in Aβ as a consequence of enhanced γ-secretase activity [104].…”

Section: Nutrients That Modulate Alzheimer’s Diseasementioning

confidence: 99%

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Modulating Effect of Diet on Alzheimer’s Disease

2019

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As life expectancy is growing, neurodegenerative disorders, such as Alzheimer’s disease, are increasing. This disease is characterised by the accumulation of intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein, senile plaques composed of an extracellular deposit of β-amyloid peptide (Aβ), and neuronal loss. This is accompanied by deficient mitochondrial function, increased oxidative stress, altered inflammatory response, and autophagy process impairment. The present study gathers scientific evidence that demonstrates that specific nutrients exert a direct effect on both Aβ production and Tau processing and their elimination by autophagy activation. Likewise, certain nutrients can modulate the inflammatory response and the oxidative stress related to the disease. However, the extent to which these effects come with beneficial clinical outcomes remains unclear. Even so, several studies have shown the benefits of the Mediterranean diet on Alzheimer’s disease, due to its richness in many of these compounds, to which can be attributed their neuroprotective properties due to the pleiotropic effect they show on the aforementioned processes. These indications highlight the potential role of adequate dietary recommendations for clinical management of both Alzheimer’s diagnosed patients and those in risk of developing it, emphasising once again the importance of diet on health.

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Section: Alzheimer’s Diseasementioning

confidence: 99%

Section: Relevance Of Dietary Patternsmentioning

confidence: 99%

Section: Relevance Of Dietary Patternsmentioning

confidence: 99%

Section: Nutrients That Modulate Alzheimer’s Diseasementioning

confidence: 99%

Section: Nutrients That Modulate Alzheimer’s Diseasementioning

confidence: 99%

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Modulating Effect of Diet on Alzheimer’s Disease

2019

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Lípidos y su relación con enfermedades neurodegenerativas en adultos

Marcillo-Marcillo,

Segura-Betancourt,

Mina-Ortiz

2024

MQRInvestigar

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En el campo de la bioquímica y la salud cerebral, se ha investigado la influencia de los lípidos en el desarrollo de enfermedades neurodegenerativas en adultos mayores. El objetivo de este estudio fue analizar las enfermedades neurodegenerativas causadas por alteraciones lipídicas, describir los mecanismos de los lípidos en su desarrollo, e identificar los efectos de los lípidos en estas enfermedades. La metodología aplicada incluyó la revisión bibliográfica de estudios primarios y secundarios publicados en los últimos 5 años, utilizando bases de datos científicas y palabras clave relacionadas con lípidos, enfermedades neurodegenerativas y adultos mayores. Se seleccionaron estudios relevantes que abordaban la relación entre los lípidos y las enfermedades neurodegenerativas en humanos. Los resultados más relevantes destacaron que el estrés oxidativo, causado por el desequilibrio entre la producción de especies reactivas de oxígeno y la capacidad de reparación del sistema biológico, es un mecanismo prominente en el desarrollo de enfermedades neurodegenerativas relacionadas con los lípidos. Se evidenció que la disminución o inhibición de los mecanismos antioxidantes endógenos puede desencadenar este estado de estrés oxidativo. Este estudio resalta la importancia de comprender la influencia de los lípidos en las enfermedades neurodegenerativas en adultos mayores, subrayando la relevancia del equilibrio lipídico y la protección contra el estrés oxidativo como posibles estrategias preventivas y terapéuticas.

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Diagnóstico Del Alzheimer Y Su Impacto Emocional en Las Familias De Los Adultos Mayores

Cedeño Macías,

Galarza Schoenfeld,

Joza Gonzalez

2024

Tejedora

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Esta investigación plantea como objetivo, comprender la relación entre el diagnóstico de Alzheimer y las repercusiones emocionales en las familias de los afectados. El problema identificado radica en la falta de comprensión integral sobre cómo el diagnóstico de Alzheimer afecta emocionalmente a las familias en Manabí, esta creciente incidencia de esta enfermedad neurodegenerativa presenta desafíos significativos para las familias, quienes a menudo experimentan ansiedad, estrés y cambios en la dinámica familiar al asumir roles de cuidadores. Se adoptó un enfoque cuantitativo donde se da la implementación de encuestas como técnicas de investigación, que brindan una visión completa de la experiencia de las familias, permitiendo identificar necesidades específicas y proponer recomendaciones para mejorar el apoyo emocional. Entre los principales resultados se conoció que 1 de 4 casos confirmados de alzheimer cuentan con historial familiar, el 85% de los cuidadores sufren de estrés emocional en diferentes niveles y solo el 15% de estos han buscado ayuda profesional, demostrando la poca importancia que los cuidadores le dan a su propia salud. En conclusión, el diagnóstico del Alzheimer afecta mayormente en la salud mental y emocional de los familiares de los adultos mayores que padecen esta enfermedad

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Dieta y prevención en enfermedad de Alzheimer

Cited by 3 publications

References 174 publications

Modulating Effect of Diet on Alzheimer’s Disease

Modulating Effect of Diet on Alzheimer’s Disease

Lípidos y su relación con enfermedades neurodegenerativas en adultos

Diagnóstico Del Alzheimer Y Su Impacto Emocional en Las Familias De Los Adultos Mayores

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