Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study

Jonge, Ester A.L. de; Koromani, Fjorda; Hofman, Albert; Uitterlinden, André G.; Franco, Oscar H.; Rivadeneira, Fernando; Jong, Jessica C. Kiefte‐de

doi:10.1007/s00198-017-4037-9

Cited by 22 publications

(22 citation statements)

References 35 publications

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“…In relation to specific nutrients, we established a plausible favorable relation between high vitamin A intake from the diet with fracture risk in overweight subjects [ 201 ]. We also determined that a diet high in acid-forming nutrients (e.g., proteins) may be detrimental to bone health in participants with high intake of dietary fibre [ 202 ]. Further, we identified dietary patterns influencing bone health, where beneficial effects on higher BMD were seen with “Health conscious” patterns in contrast to patterns characterized “Processed food” indicate potential susceptibility to presenting low BMD [ 117 ].…”

Section: Locomotor Diseasesmentioning

confidence: 99%

The Rotterdam Study: 2018 update on objectives, design and main results

et al. 2017

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The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

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Section: Locomotor Diseasesmentioning

confidence: 99%

The Rotterdam Study: 2018 update on objectives, design and main results

et al. 2017

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“…As a consequence, the increased acid production can lead to a decrease in muscle mass [ 42 , 43 , 44 , 45 ]. In addition, regular acidic diet may trigger a reduction in bone mineralisation, an increase in urinary calcium excretion and pose a risk of bone fractures [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Acid-Base Balance in High-Performance Athletes

Baranauskas

Jablonskienė

Abaravičius

et al. 2020

IJERPH

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Physical exercise leads to metabolic changes that affect the acid-base balance in skeletal muscles and other tissues. Nutrition is one of the factors that may influence the acid-base balance in the body. Keeping alkaline circumstances in the body is important not only for health and athletic performance in training but also during competition in many sport events. This is especially significant for athletes who practice in sport at the highest level of competition. The aim of the study was to determine the dietary acid-base balance in competitive Lithuanian high-performance athletes, and to evaluate the effect of actual diets of athletes on NEAP (net endogenous acid production), muscle mass and body mineral content during a four-year Olympic cycle. The research participants were 18.1 ± 3.3-year-old Lithuanian high performance athletes (n = 323). The actual diet was investigated using the 24 h recall dietary survey method. The measurements of body composition were performed using BIA (bioelectrical impedance analysis). The potential renal acid load of the diets of athletes (dietary PRAL) and NEAP were calculated. In 10.2% of athletes, NEAP exceeds 100 mEq · day−1 and is on average 126.1 ± 32.7 mEq · day−1. Higher NEAP in athletes is associated with lower muscle mass (β -1.2% of body weight, p < 0.001) but has no effect on the amount of minerals in the body (β 0.01% of body weight, p = 0.073). Overall, 25–30% of Lithuanian high-performance athletes use high-protein diets (2.0–4.8 g · kg−1 · day−1) leading to a dietary acid-base imbalance as well as an excessive production of endogenous acids in the body. Athletes are recommended to consume higher amounts of potassium and magnesium. An increase in calcium intake up to 1500 mg per day is recommended. In exceptional cases, periodised nutrition for athletes may involve diets complemented with bicarbonate and/or beta-alanine supplements.

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“…To our knowledge, there have been no studies on LD use and LS-TBS. TBS is a measurement related to bone microarchitecture which provides skeletal information that is not captured from the standard BMD measurements [31]. Also, TBS might be an appropriate measure to study in regard to lifestyle factors that are adaptable, such as dietary intake [31,32].…”

Section: Discussionmentioning

confidence: 99%

“…TBS is a measurement related to bone microarchitecture which provides skeletal information that is not captured from the standard BMD measurements [31]. Also, TBS might be an appropriate measure to study in regard to lifestyle factors that are adaptable, such as dietary intake [31,32]. Other studies have reported lower TBS among individuals with primary hyperparathyroidism [38].…”

Section: Discussionmentioning

confidence: 99%

“…LS-TBS predicts future fractures (all type) independent of areal BMD [30]. Moreover, recent studies have shown that LS-TBS may be an applicable measure of trabecular bone integrity to study in regard to lifestyle factors that are adaptable, such as a dietary intake [31,32]. LS-TBS was derived from the same lumbar DXA scans that BMD was obtained from and it was analysed using TBS iNsight software (version 1.9; Medimaps, Geneva, Switzerland) at the Bone Disease Unit of the University of Lausanne (Lausanne, Switzerland).…”

Section: Outcome Assessmentmentioning

confidence: 99%

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Do Vitamin D Level and Dietary Calcium Intake Modify the Association Between Loop Diuretics and Bone Health?

et al. 2019

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Loop diuretics (LD) may affect bone health by inhibiting renal calcium reuptake. However, whether vitamin D status and dietary calcium intake modify the association between LD and bone outcome is unclear. Therefore, this study aimed to evaluate whether vitamin D level or calcium intake modify the association between LD and various indices of bone health including bone mineral density (BMD) and Trabecular Bone Score (TBS). From The Rotterdam Study, a prospective population-based cohort study, we used data from 6990 participants aged > 45 year with a DXA scan (2002-2008), 6908 participants with femoral neck (FN)-BMD, 6677 participants with lumbar spine (LS)-BMD and 6476 participants with LS-TBS measurements. Use of LD was available from pharmacy dispensing records. Vitamin D (25(OH)D) level was measured in serum, and dietary calcium intake was measured with a validated food frequency questionnaire. Almost eight percent of the participants used LD. The association between LD (past-users compared to never-users) and LS-TBS was significantly different by 25(OH) D concentrations (P for interaction = 0.04). A significantly lower LS-TBS among LD past-users was observed for 25(OH) D ≥ 50 nmol/l compared to ≤ 20 and 20-50 nmol/l (β = − 0.036, 95% CI − 0.060; − 0.013 vs. β = − 0.012, 95% CI − 0.036; 0.013 and β = − 0.031, 95% CI − 0.096; 0.034, respectively). However, no other significant effect modification by 25(OH)D and dietary calcium intake was found in the associations between LD use and bone health outcomes (P-interaction > 0.13). This study suggests that the association between LD use and indices of bone health is not consistently modified by vitamin D or dietary calcium intake.

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Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study

Cited by 22 publications

References 35 publications

The Rotterdam Study: 2018 update on objectives, design and main results

The Rotterdam Study: 2018 update on objectives, design and main results

Dietary Acid-Base Balance in High-Performance Athletes

Do Vitamin D Level and Dietary Calcium Intake Modify the Association Between Loop Diuretics and Bone Health?

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