Dietary Acrylamide Intake during Pregnancy and Postnatal Growth and Obesity: Results from the Norwegian Mother and Child Cohort Study (MoBa)

Abstract

Background: Prenatal acrylamide exposure has been negatively associated with fetal growth but the association with child growth is unknown. Objectives: We studied the association between prenatal acrylamide exposure and child postnatal growth up to 8 years in the Norwegian Mother and Child Cohort Study (MoBa). Methods: In 51,952 mother-child pairs from MoBa, acrylamide intake during pregnancy was estimated by combining maternal food intake with food concentrations of acrylamide. Mothers reported their child's weight and length/height up to 11 times between 6 weeks and 8 years. Weight and height growth trajectories were modelled using Jenss-Bayley's growth model. Logistic regression models were used to study the association with overweight/obese status at 3, 5 and 8 years, as identified using the International Obesity Task Force cutoffs. Linear mixed-effect models were used to explore associations with overall growth. Results: At 3 years, the adjusted odds ratios (95% Confidence Intervals (CI)) of being overweight/obese were 1.10 (1.02, 1.20), 1.12 (1.04, 1.22) and 1.21 (1.11, 1.31) by increasing prenatal acrylamide exposure quartile. Similar dose-response associations were found at 5 and 8 years. Acrylamide intake during pregnancy was associated with higher weight growth velocity in childhood. Children exposed at the highest level had 22g (95%CI: 8, 37), 57g (95%CI: 32, 81), and 194g (95%CI: 110, 278) higher weight at 0.5, 2, and 8 years, respectively, compared to their low exposed peers. Conclusions: Children prenatally exposed to acrylamide in the highest quartile experienced a moderate increase in weight growth velocity during early childhood that resulted in a moderately increased prevalence of overweight/obesity compared to peers in

Environmental contaminants and child’s growth

“…Three longitudinal studies have shown a relationship between higher maternal acrylamide exposure and lower birth weight or higher risk of having a small for gestational age baby 123 124 To our knowledge one study showed a positive association between acrylamide exposure and postnatal growth 125 …”

Relationship between gestational acrylamide exposure and offspring’s growth: a systematic review and meta-analysis of cohort studies

“…A recent study indicated the significant associations between AA exposure level and the likelihoods of allergy-related outcomes in the general US population (6) . The biological mechanisms for the effects of AA on Study or Subgroup Kadawathagedara et al (10) Kadawathagedara et al (10) b Kadawathagedara et al (10) c Kadawathagedara et al (9) a Kadawathagedara et al (9) b Kadawathagedara et al (9) c Nagata et al (12) e Nagata et al (12) f Pedersen et al (11) a Pedersen et al (11) b Pedersen et al (11) c Total (95 % CI) Heteogeneity: Tau Kadawathagedara et al (10) a Duarte-Salles et al (8) a Duarte-Salles et al (8) b Duarte-Salles et al (8) c Kadawathagedara et al (10) b Kadawathagedara et al (10) c Pedersen et al (11) Total (95 % CI) Heteogeneity: Tau Nagata et al (12) e Nagata et al (12) f Pedersen et al (11) a Pedersen et al (11) b…”

“…A total of 1028 articles were identified, and after removal of duplicates (n 474), 554 articles remained. After title and abstract screening and full-text review, five full-text studies (8)(9)(10)(11)(12) met the inclusion criteria and were remained for the present meta-analysis.…”

“…Five studies (8)(9)(10)(11)(12) (two studies (8,9) had overlapping study samples) reported the relationship between prenatal AA exposure and birth weight. The pooled SMD suggested that offspring's birth weight was significantly lower in high AA exposure group (SMD -0•05, 95 % CI -0•09, -0•02, P = 0•005) (Fig.…”

“…Secondary outcomes: acrylamide and offspring's growth One study (9) reported the association between prenatal AA exposure and offspring's overweight/obesity. OR suggested that children had a high risk of developing overweight/obesity in the future in maternal high AA exposure group ( Fig.…”