Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat

Scherhag, R; Kramer, Herbert J.; Düsing, Rainer

doi:10.1016/0090-6980(82)90082-x

Cited by 78 publications

(16 citation statements)

References 23 publications

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“…EPA in the diet obviously resulted in a decreased synthesis of PGI 2 in the skin as well as in aorta. This confirms earlier observations with regard to rat aorta [7,8,9]. In contrast to PGI2, the release of PGE2 was not lower in the skin of rats on an EPA-containing diet.…”

Section: Discussionsupporting

confidence: 93%

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Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2

Sametz

Juan

1985

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The influence of feeding a marine oil (MaxEPA) with a high content of eicosapentaenoic acid (EPA) to rats for 10 weeks on the development of carrageenin oedema was studied. Since prostaglandins (PGs) are involved in the development of this acute experimental inflammation, the influence of EPA feeding on PG release from aorta (PGI2) and from the subplantar skin of the inflamed foot (PGI2, PGE2) was investigated also. MaxEPA was fed in two daily doses containing 50 or 100 mg EPA/kg/day. In both rat groups there was no influence of EPA on the development of the oedema. However, the capacity of aorta and skin of the plantar region of the experimentally inflamed foot to release PGI2 was strongly reduced by EPA. On the other hand, the release of PGE2 from the skin was not reduced. Indomethacin at a low dose (2 mg/kg perorally) reduced the development of the paw oedema as well as the release of PGs in control rats and rats on an EPA-containing diet. It is concluded that EPA did not influence carrageenin oedema because there was an adequate production of the oedema promoting substance PGE2.

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Section: Discussionsupporting

confidence: 93%

“…Feeding fat fish or fish oils containing high amounts of eicosapentaenoic acid (20: 5, n-3) to rats has been found to reduce the release of at least prostacyclin [7,8,9]. Thus, the question arose as to whether feeding EPA would reduce an acute inflammation by inhibition of PG formation.…”

Section: Introductionmentioning

confidence: 98%

Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2

Sametz

Juan

1985

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“…In Wistar rats the n-3 fatty acids block salt-induced rises in blood pressure (Ziemlanski et al, 1985). Contrastingly, however in the Sprague-Dawley rat high doses of EPA and DHA increased blood pressure, suppressing vascular production of prostacyclins (Scherhag et at., 1982). Wistar-Kyoto rats, used as controls in studies of the spontaneously hypertensive rat (SHR) exhibit no response to n-3 fatty acids (Schoene et al, 1981).…”

Section: Discussionmentioning

confidence: 93%

“…High fat diets, regardless of the type of fat used, increase blood pressure (Bursztyn et al, 1972;Bursztyn & Firth, 1975). n-6 (MacDonald et Dusing et al, 1983) and n-3 (Scherhag et al, 1982) fatty acid classes both appear to have specific modulatory effects.…”

Section: Introductionmentioning

confidence: 95%

Influence of Dietary Fats Upon Systolic Blood Pressure in the Rat

Langley‐Evans

Clamp

Grimble

et al. 1996

International Journal of Food Sciences and Nutrition

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Studies were performed to determine whether feeding diets with differing fatty acid content and composition had an influence on systolic blood pressure in the rat. Weanling male rats were fed standard laboratory chow (2.9% fat in total), or synthetic diets (10% fat in total) containing fish oil, butter, coconut oil or corn oil, for 5 weeks. Coconut oil and butter diets were rich in saturated fatty acids, whilst fish oil and corn oil were rich in the n-3 and n-6 unsaturated fatty acids respectively. Systolic blood pressure was measured using an indirect tail-cuff method at the end of the feeding period, and compared to a group of weanling rats. Feeding the different diets did not alter the growth of the rats, so all animals were of similar weights at the time of blood pressure determination. Control (chow fed) animals, at nine weeks of age, had higher systolic blood pressures than the weanling, baseline control group. Fish oil fed rats had similar pressures to the chow fed rats. Corn oil fed rats had significantly lower systolic pressures than the controls. The rats led the diets rich in saturated fatty acids (butter and coconut oil) had significantly higher blood pressures than all other groups. Systolic blood pressure was found to be significantly related to the dietary intakes of saturated and unsaturated fatty acids. The dietary intake of linoleic acid was significantly higher in corn oil fed rats than in other groups. Systolic blood pressure was inversely related to linoleic acid intake. Feeding a diet rich in saturated fatty acids significantly increases blood pressure in the rat. A high intake of n-6 fatty acids, and in particular linoleic acid, appears to have a hypotensive effect. Prenatal exposure of the rats to a maternal low protein diet, abolished the hypertensive effects of the coconut oil diet and the hypotensive effect of the corn oil diet upon young adult females. The intrauterine environment may, therefore, be an important determinant of the effects of these fatty acids on blood pressure in later life.

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“…At present there is considerable interest in the nutritional properties of polyunsaturated fatty acids [1,2], particularly those n-3 poly unsaturated fatty acids of marine origin, where there is increasing evidence for their preventive role in the development of coro nary heart disease in man [3,4], In studies in either experimental animals or man, various fish oil diets have been reported to alter blood pressure [5,6], lower serum cholesterol levels [7], increase bleeding time [8], reduce platelet aggregation [9], and prevent exper imental myocardial infarction [10]. Many of the effects are thought [3] to be mediated by the long-chain metabolites of a-linolenic acid (18:3,n-3) which include eicosapentaenoic acid (20:5,n-3), docosapentaenoic acid (22:5,n-3), and docosahexaenoic acid (22:6, n-3).…”

Section: Introductionmentioning

confidence: 99%

Altered Levels of n-6/n-3 Fatty Acids in Rat Heart and Storage Fat following Variable Dietary Intake of Linoleic Acid

et al. 1985

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Fat-supplemented diets enriched with linoleic acid by the addition of 12% w/w sunflower seed oil or proportionally reduced in linoleic acid by addition of 12% mutton fat were fed to rats for 18 months before the fatty acid composition of perirenal storage fat and myocardial membranes (phospholipids) was determined. Although the fatty acid composition of perirenal fat generally reflected that of the diet, there was an inverse relationship between the consumption of n-6 and the deposition of n-9 fatty acids. In addition, enhanced deposition of oleic acid (18:l, n-9) appears to be related to the dietary intake of stearic acid (18:0). In contrast, in myocardial membranes the n-3 polyunsaturated fatty acids are found to be increased when the intake of n-6 polyunsaturated fatty acids is reduced. This is particularly evident for docosahexaenoic acid (22:6, n-3) which is significantly increased in phosphatidylcholine, phosphatidylethanolamine, and diphosphatidylgycerol fractions of myocardial membranes, when the mutton fat diet was fed. After feeding the sunflower seed oil diet, the increased consumption of linoleic acid produced only small changes in the 18:2, n-6 content of cardiac phosphatidylcholine and phosphatidylethanolamine. These major classes of membrane phospholipids also showed only small increases in 20:4, n-6. In diphosphatidylglycerol, increased 18:2, n-6 also followed increased dietary intake, but this was not accompanied by increased 20:4, n-6. These changes in myocardial phospholipid fatty acid composition are similar to those observed after short-term feeding reported previously and confirm that changes in dietary n-6/n-3 fatty acid intake affect the fatty acid composition of both myocardial membranes and storage fat. These changes persist for the duration of the feeding period.

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Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat

Cited by 78 publications

References 23 publications

Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2

Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2

Influence of Dietary Fats Upon Systolic Blood Pressure in the Rat

Altered Levels of n-6/n-3 Fatty Acids in Rat Heart and Storage Fat following Variable Dietary Intake of Linoleic Acid

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