2018
DOI: 10.1101/342691
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Dietary Advanced Glycation End-Product Consumption Leads to Mechanical Stiffening of Murine Intervertebral Discs

Abstract: StatementDietary advanced glycation end-products (AGE) lead to sex-specific intervertebral disc structural and functional changes and may be targeted for promoting spinal health especially in diabetes where AGEs form rapidly. ABSTRACTBack pain is a leading cause of disability strongly associated with intervertebral disc (IVD) degeneration. Reducing structural disruption and catabolism in IVD degeneration remains an important clinical challenge. Pro-oxidant and structuremodifying advanced glycation end-products… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
36
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
6

Relationship

3
3

Authors

Journals

citations
Cited by 12 publications
(38 citation statements)
references
References 49 publications
2
36
0
Order By: Relevance
“…We identified 9511 published studies related to the issue IVDD. Out of these 27 manuscripts were related to the topic IVDD in diabetic rodent models, which is our research field of interest [ 3 , 15 , 43 , 47 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ], see Table 4 and Table 5 . By further evaluation another four publications were excluded; two of them discussed the diabetic animal models used in IVDD, including rodents, but they were not related to IVDD.…”
Section: Resultsmentioning
confidence: 99%
See 4 more Smart Citations
“…We identified 9511 published studies related to the issue IVDD. Out of these 27 manuscripts were related to the topic IVDD in diabetic rodent models, which is our research field of interest [ 3 , 15 , 43 , 47 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ], see Table 4 and Table 5 . By further evaluation another four publications were excluded; two of them discussed the diabetic animal models used in IVDD, including rodents, but they were not related to IVDD.…”
Section: Resultsmentioning
confidence: 99%
“…LBP affects up to 85% of people around the world and occurs at some point in their lives [ 1 , 2 ]. Degeneration of the intervertebral disc (IVDD) is considered to be an important underlying cause of LBP [ 3 , 4 ], back, neck, and radicular pains [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
See 3 more Smart Citations