Dietary agents in mitigating chemotherapy-related cognitive impairment (chemobrain or chemofog): first review addressing the benefits, gaps, challenges and ways forward

Raghu, Shamprasad Varija; Kudva, Avinash K.; Rao, Suresh; Prasad, Krishna; Mudgal, Jayesh; Baliga, Manjeshwar Shrinath

doi:10.1039/d1fo02391h

Cited by 4 publications

(3 citation statements)

References 212 publications

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“…Our results working with the modulator of the nAChRs, Cotinine, acting as a positive allosteric modulator of the α7nAChRs enhanced contextual fear memory extinction without altering the acquisition and short-term retention of fear memory in a nAChR dependent-manner ( Lotfipour et al, 2013 ). Based on th current evidence, we have postulated that cotinine-induced enhancement of extinction is mediated by increased neuronal plasticity and neurogenesis in rodents ( Echeverria et al, 2017 ; Sadigh-Eteghad et al, 2020 ; Bastianini et al, 2021 ; Raghu et al, 2021 ). Few years ago, Sadigh-Eteghad et al (2020) found that chronic cotinine ameliorated learning and memory in aged animals in the MWM and novel object recognition (NOR) tasks ( Sadigh-Eteghad et al, 2020 ), and also increased the expression of (a) antioxidant factors such as the superoxide dismutase (SOD), (b) synaptic proteins (PSD95, GAP-43, and synaptophysin), (c) neurotrophic factors brain-derived neurotrophic factor (BDNF), and neural growth factor (NGF), while decreasing cytokines (TNFα and IL1β) in the hippocampus of aged mice ( Sadigh-Eteghad et al, 2020 ).…”

Section: Role Of the Nachrs In Learning And Memorymentioning

confidence: 99%

Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases

2023

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Animal survival depends on cognitive abilities such as learning and memory to adapt to environmental changes. Memory functions require an enhanced activity and connectivity of a particular arrangement of engram neurons, supported by the concerted action of neurons, glia, and vascular cells. The deterioration of the cholinergic system is a common occurrence in neurological conditions exacerbated by aging such as traumatic brain injury (TBI), posttraumatic stress disorder (PTSD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). Cotinine is a cholinergic modulator with neuroprotective, antidepressant, anti-inflammatory, antioxidant, and memory-enhancing effects. Current evidence suggests Cotinine’s beneficial effects on cognition results from the positive modulation of the α7-nicotinic acetylcholine receptors (nAChRs) and the inhibition of the toll-like receptors (TLRs). The α7nAChR affects brain functions by modulating the function of neurons, glia, endothelial, immune, and dendritic cells and regulates inhibitory and excitatory neurotransmission throughout the GABA interneurons. In addition, Cotinine acting on the α7 nAChRs and TLR reduces neuroinflammation by inhibiting the release of pro-inflammatory cytokines by the immune cells. Also, α7nAChRs stimulate signaling pathways supporting structural, biochemical, electrochemical, and cellular changes in the Central nervous system during the cognitive processes, including Neurogenesis. Here, the mechanisms of memory formation as well as potential mechanisms of action of Cotinine on memory preservation in aging and neurological diseases are discussed.

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Section: Role Of the Nachrs In Learning And Memorymentioning

confidence: 99%

Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases

2023

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“…This fungus is primarily found in the Tibetan Plateau and surrounding regions, including Qinghai, Tibet, Gansu, Sichuan, and Yunnan provinces in China, as well as certain areas in Bhutan and Nepal, typically at altitudes ranging from 3500 to 5000 m [ 2 ]. Modern pharmacological studies have revealed its diverse biological activities, such as hepatorenal protection has, for example revealed its diverse biological activities; hepatorenal protection [ 3 , 4 ], immunomodulation [ 5 ], anti-aging [ 6 ], anti-inflammatory [ 7 ], and anti-tumor effects [ 8 ]. However, due to its highwater content, a suitable drying method is essential to preserve the nutritional value, efficacy, and taste of Cordyceps sinensis [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Drying Methods on Morphological Characteristics, Metabolite Content, and Antioxidant Capacity of Cordyceps sinensis

Xiao,

Wang,

Tang

et al. 2024

Foods

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Cordyceps sinensis is a rare and endangered medicinal herb in China and a typical medicinal and food plant. Most of the research related to Cordyceps sinensis focuses on its pharmacological effects, artificial cultivation and clinical applications. However, there are few comprehensive evaluations on the quality of Cordyceps sinensis under different drying methods. In this study, the effects of vacuum freeze-drying (DG), oven-drying (HG) and air-drying (YG) on the morphological characteristics, microstructure, antioxidant activity and metabolites of Cordyceps sinensis were investigated using wild Cordyceps sinensis as the research object. The results showed that in their appearance and morphology, the YG- and HG-method Cordyceps sinensis samples were darker in color and wilted, while the DG- method Cordyceps sinensis samples were golden yellow in color and had better fullness. In terms of microstructure, the stomata of the YG and HG method Cordyceps sinensis samples were relatively small and irregularly shaped, whereas those of the DG method Cordyceps sinensis samples were larger and neat. In terms of antioxidant capacity, the HG-method samples were the lowest, followed by the YG group, and the DG group had the highest total antioxidant capacity. A correlation analysis revealed a significant relationship between antioxidant capacity and lipids, lipid molecules, nucleosides, nucleotides, and analogs. A metabolomics analysis identified 1937 metabolites from 18 superclasses, with lipids, lipid-like molecules, organic acids and derivatives, organoheterocyclic compounds, and organic oxygen compounds being the predominant metabolites in Cordyceps sinensis. Differentially accumulated metabolites (DAMs) in DG samples showed higher levels of lipids and lipid molecules, organic oxygen compounds, organic acids and derivatives, and organoheterocyclic compounds compared to the other drying methods, suggesting DG as the optimal preservation method for Cordyceps sinensis. These findings offer insights for selecting appropriate drying methods and maintaining the post-drying quality of Cordyceps sinensis.

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“… 2 Chemobrain or chemofog, chemotherapy-induced cognitive dysfunction, is widely recognized as a common adverse reaction following the administration of chemotherapeutic drugs. 3 More than 75% of cancer patients suffered from it. 4 Its clinical manifestations include forgetfulness, trouble with multi-tasking and executing tasks, learning difficulties, memory problems, and poor attention span.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization

Liu¹,

Tang²,

He³

et al. 2023

DDDT

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Objective This study aimed to investigate the effect of resveratrol (Res) on paclitaxel (PTX)-induced cognitive impairment and elucidate the underlying molecular mechanisms. Methods Morris Water Maze (MWM) test was used to evaluate the mice’s spatial learning and memory abilities. Western blotting was applied to detect protein expression of receptor-interacting protein (RIP3), mixed lineage kinase domain-like protein (MLKL), silencing information regulator 2 related enzyme 1 (SIRT1), peroxisome proliferator activated receptor coactivator-1 (PGC-1α), NADPH oxidase 2 (NOX2), NOX4, postsynaptic density zone 95 (PSD95), arginase-1 (Arg-1) and inducible nitric oxide synthase (iNOS). Immunofluorescence of RIP3, MLKL, Arg-1, Iba-1 and iNOS was conducted to observe the apoptosis of hippocampal cells and the polarization of microglia. qRT-PCR was performed to detect BDNF mRNA expressions. DHE staining was used to assess the level of oxidative stress response. Golgi-Cox staining and dendritic spine counting were applied to visualize synaptic structural plasticity. Postsynaptic density was performed by transmission electron microscope. ELISA was used to detect the contents of tumour necrosis factor alpha (TNF-α), IL-1β, IL-4, and IL-10. Results PTX-induced cognitive impairment model was constructed after the application of PTX, represented as longer latency to platform and less platform crossing times over the whole period in PTX group. After Res treatment, the above indicators were reversed, indicating that cognitive function was improved. Moreover, Res reduced neuronal apoptosis and oxidative stress through SIRT1/PGC-1α pathway in mice, manifesting as down-regulated expression of RIP3, MLKL, NOX2 and NOX4. Meanwhile, Res increased the density of dendritic spines and the expression of PSD95 and BDNF, thereby ameliorating the PTX induced synaptic damage. Besides, M2 microglia was in the majority, eliciting the expression of anti-inflammatory cytokines IL-4 and IL-10 after Res treatment in PTX+Res group, while immunofluorescence images results demonstrated an decrease in the proportion of M2 microglia a following SIRT1 inhibitor EX-527. Conclusion Res improves PTX-induced cognitive impairment in mice by activating SIRT1/PGC-1α pathways to regulate neuronal state and microglia cell polarization.

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Dietary agents in mitigating chemotherapy-related cognitive impairment (chemobrain or chemofog): first review addressing the benefits, gaps, challenges and ways forward

Abstract: Chemobrain or chemofog is one of the important but less investigated side effects, where the cancer survivors treated with chemotherapy develop long-term cognitive impairments, affecting their quality of life.

Cited by 4 publications

References 212 publications

Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases

Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases

Effects of Drying Methods on Morphological Characteristics, Metabolite Content, and Antioxidant Capacity of Cordyceps sinensis

Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization

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