Dietary and Lifestyle Factors and Medical Conditions Associated with Urinary Citrate Excretion

Mandel, Ernest I.; Taylor, Eric N.; Curhan, Gary C.

doi:10.2215/cjn.07190712

Cited by 34 publications

(16 citation statements)

References 51 publications

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“…We found thiazide use associated with decreased urinary citrate, as previously shown (Mandel et al. ). This is likely caused by thiazide‐induced hypokalemia, which would stimulate citrate reabsorption in the proximal tubules (Zuckerman and Assimos ).…”

Section: Discussionsupporting

confidence: 90%

“…Conversely, Mandel and colleagues found having high BMI was associated with a lower urinary citrate (Mandel et al. ). Since we found an effect of weight, but not BMI on urinary citrate in the main effects model, it suggests that body habitus is important.…”

Section: Discussionmentioning

confidence: 98%

“…Powell and colleagues studied 5942 stone formers of which 414 were obese (>120 kg in males >100 kg in females) and also found the obese group to have a higher 24-h urinary citrate excretion (Powell et al 2000). Conversely, Mandel and colleagues found having high BMI was associated with a lower urinary citrate (Mandel et al 2013). Since we found an effect of weight, but not BMI on urinary citrate in the main effects model, it suggests that body habitus is important.…”

Section: Discussionmentioning

confidence: 99%

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Association of urinary citrate excretion, pH, and net gastrointestinal alkali absorption with diet, diuretic use, and blood glucose concentration

et al. 2017

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Urinary citrate (Ucit) protects against urinary stone formation. Acid base status and diet influence Ucit. However, the effect of demographics, diet, and glucose metabolism on Ucit excretion, urinary pH (U‐pH) and net gastrointestinal alkali absorption (NAA) are not known. Twenty‐four hour urine samples, blood glucose, creatinine, and cystatin C were obtained from non‐Hispanic white sibships in Rochester, MN (n = 446; 64.5 ± 9 years; 58% female). Diet was assessed by a food frequency questionnaire. The impact of blood glucose, demographics and dietary elements on Ucit excretion, U‐pH, and NAA were evaluated in bivariate and multivariable models and interaction models that included age, sex, and weight. NAA significantly associated with Ucit and U‐pH. In multivariate models Ucit increased with age, weight, eGFRC ys, and blood glucose, but decreased with loop diuretic and thiazide use. U‐pH decreased with serum creatinine, blood glucose, and dietary protein but increased with dietary potassium. NAA was higher in males and increased with age, weight, eGFRC ys and dietary potassium. Significant interactions were observed for Ucit excretion with age and blood glucose, weight and eGFRC ys, and sex and thiazide use. Blood glucose had a significant and independent effect on U‐pH and also Ucit. This study provides the first evidence that blood glucose could influence urinary stone risk independent of urinary pH, potentially providing new insight into the association of obesity and urinary stone disease.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Association of urinary citrate excretion, pH, and net gastrointestinal alkali absorption with diet, diuretic use, and blood glucose concentration

et al. 2017

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“…Not only this, other studies which are conducted in two different countries also supported the association of carbohydrate-rich food with kidney stone disease, they reported that kidney stone disease had a strong significant correlation with higher intake of cereals, grains, and caffeine (Amin et al 2017;Ryu et al 2017). Coming to the prevention of kidney stone formation, increase intake of fruits and vegetables lower the risk of kidney stone (Meschi et al 2004;Salmeh et al 2012;Yasui et al 2013;Mandel et al 2013) whereas green leafy vegetables which have higher amount of oxalate contains are also risk factors for the formation of kidney stone, consumption of leafy vegetables that contain high oxalate, more than three times per day also resulted in the formation of kidney stones in both men and women (Dai et al 2013). Less physical activity is also one of the major risk factors for the formation of kidney stone disease.…”

Section: Resultsmentioning

confidence: 77%

Association of kidney stone disease with dietary factors: a review

Konjengbam¹,

Meitei²

2020

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Kidney stone disease is one of the most common urologic disorders worldwide. The incidence of kidney stones disease is increasing all over the world. It is a multifactorial disease accompanied by various factors. The dietary factor is one of the most important risk factors for the formation and recurrence of kidney stone disease. Formation and recurrence of kidney stone disease can be prevented by modifying our day to day dietary habits. Fewer intakes of animal protein, higher intake of fluid, higher intake of fruits, and higher intake of green leafy vegetables, which contain a low amount of oxalate, can prevent the formation of kidney stones and recurrence of kidney stones. From this review, it may be presumed that the higher prevalence rate of kidney stone disease in northeast India may be the dietary factors accompanied by environmental and climatic conditions of the region.

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“…Nonetheless, hypertension, diabetes mellitus and chronic kidney disease (CKD) were proved to be correlated with nephrolithiasis. Many authors agree and it is our firm belief that stones in patients with CKD should be cleared [5]. However, the risk factor that may influence the calculus kidney damage is still unclear and needs further evaluation.…”

Section: Introductionmentioning

confidence: 96%

Correlative Analysis Between Severity of Urolithiasis and Laboratory Parameters and Its Implication in Evaluation of the Probable Risk Profile

T.P¹,

Singh²,

Barua³

et al. 2018

World J Nephrol Urol

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Background: Urolithiasis presents serious hazard which significantly elevates the cost of national health expenditure in almost every part of both the hemispheres. There is high risk of hospitalization with loss of valuable human resource and decreased productivity along with it. Risk factors still evade the exact etiology and search for optimal serum panel is still in its infancy. Urolithiasis incidence has gradually increased in last 3 decades which suggests that some constant metabolic and urinary parameters are implicated in the risk of occurrence of urinary stone. The present study is intended to identify a panel of serum parameters, urinary parameters, radiological characteristics and correlating it with the clinical severity of stone disease. Methods: The present study was conducted at the Department of Urology at GMCH Guwahati. The authors retrospectively analyzed 151 patients undergoing stone surgery from a period of January 2016 to August 2017. Data comprised of all serum and urinary examinations done 1 week preoperatively and radiological scans within 1 month before surgery. Spearman test was used to determine correlation and analysis of variance (ANOVA) was applied for comparison between more than two categories. Results: Stone multiplicity was positively correlated with upper tract stone sides (r = 0.530, P < 0.01), large stone volume (r = 0.172, P < 0.02), stone recurrence, urinary infection and urine protein. Upper tract stone sides number was positively correlated with upper tract obstruction sides (r = 0.542, P < 0.03), large stone volume (r =-0.321, P < 0.01). Upper tract obstruction sides number was positively correlated with large stone volume (r =-0.848, P < 0.01). Conclusions: Results demonstrated that urinary tract obstruction and total stone volume significantly correlated with abnormal serum panel, urinary profile and were harbinger of complex stone pattern.

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Dietary and Lifestyle Factors and Medical Conditions Associated with Urinary Citrate Excretion

Cited by 34 publications

References 51 publications

Association of urinary citrate excretion, pH, and net gastrointestinal alkali absorption with diet, diuretic use, and blood glucose concentration

Association of urinary citrate excretion, pH, and net gastrointestinal alkali absorption with diet, diuretic use, and blood glucose concentration

Association of kidney stone disease with dietary factors: a review

Correlative Analysis Between Severity of Urolithiasis and Laboratory Parameters and Its Implication in Evaluation of the Probable Risk Profile

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