Dietary and lifestyle guidelines for the prevention of Alzheimer's disease

Barnard, Neal D.; Bush, Ashley I.; Ceccarelli, Andrea; Cooper, James; Jager, Celeste de; Erickson, Kirk I.; Fraser, Gary E.; Kesler, Shelli R.; Levin, Susan; Lucey, Brendan P.; Morris, Martha Clare; Squitti, Rosanna

doi:10.1016/j.neurobiolaging.2014.03.033

Cited by 284 publications

(184 citation statements)

References 51 publications

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“…However, this does not rule out the hereditary aspect of some of these neurodegenerative diseases [4]. There are reports that degenerative diseases such as Alzheimer's, Parkinson and other forms of dementia related diseases may be preventable if there is prior neuronal protection using herbs and other food types [5,6].…”

Section: Introductionmentioning

confidence: 99%

Rauwolfia vomitoria and Gongronema latifolium extracts influences cerebellar cortex

Ekong¹,

Nwakanma²

2017

Alzheimers Dement Cogn Neurol

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Oxidative stress and free radical production is an etiology to some neurodegenerative diseases which may be preventable by prior neuronal protection using herbs. Rauwolfia vomitoria and Gongronema latifolium are medicinal herbs with antioxidant, anti-diabetic and analgesic properties among others. While R. vomitoria acts as a brain stimulant, as well as a depressant, neurotoxic effects have also been reported, which G. latifolium has shown the potential to mitigate. This study therefore investigated the effects of the combination of R. vomitoria and G. latifolium on young rats' cerebellar cortex. Twenty young male Wistar rats (100-150 g) were divided equally into 4 groups (n=5). Oral doses of the vehicle (Tween 20™), ethanolic extracts of 200 mg/kg of R. vomitoria (RV), 200 mg/kg of G. latifolium (GL), and the combination of both (RV + GL) were given to the animals for 14 days. On day 15, the animals were sacrificed after ketamine sedation and perfusion-fixed with 10% buffered-formalin. The cerebella were excised and processed for histomorphology by silver impregnation technique and immunolabelled with anti-neuron specific enolase (NSE) and glial fibrillary acidic protein (GFAP). The histology results showed atrophied Purkinje and other neurons with increased NSE and GFAP expressions in the RV group, which were not as such in the GL and RV+GL groups, an indication of cerebellar cortical injury. In conclusion, RV was injurious to the cerebellar cortical neurons and also stimulated NSE and GFAP, but these RV-induced traumas were slightly mitigated with GL combination. This preliminary report of RV+GL combination may be considered an alternative to RV single treatment for better disease management and brain protection.

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Section: Introductionmentioning

confidence: 99%

Rauwolfia vomitoria and Gongronema latifolium extracts influences cerebellar cortex

Ekong¹,

Nwakanma²

2017

Alzheimers Dement Cogn Neurol

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“…El consumo de ácidos grasos poliinsaturados protege contra enfermedades vasculares, ya que mejoran algunos factores de riesgo asociados, son capaces de disminuir los triglicéridos, la presión arterial y mejorar el funcionamiento del miocardio 14 , al contrario, una dieta que involucre el consumo de grasas saturadas y trans aumenta el riesgo de enfermedades cardiovasculares, DM II y con ello EA 43,46 .…”

Section: Dieta Mediterránea Y Protección Cardiovascularunclassified

Dieta mediterránea y sus efectos benéficos en la prevención de la enfermedad de Alzheimer

2017

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Role of Mediterranean diet on the prevention of Alzheimer diseaseL a Enfermedad de Alzheimer (EA) es la causa más común de demencia en los adultos mayores afectando a 11% de ellos, la incidencia aumenta con la edad 1 y en Chile la prevalencia de demencia en los mayores de 60 años es 10,4% según cifras de la Encuesta Nacional de Salud 2009-2010, ubicándose dentro de las 10 primeras causas de muerte de este grupo etario 2 , siendo un tema importante en salud pública, ya que el envejecimiento se relaciona con el desarrollo de deterioro cognitivo y sumado al aumento en la esperanza de vida poblacional, gatilla que patologías como la EA vayan en aumento 3 .En lo que respecta a su etiopatogenia, se ha establecido que la pérdida neuronal y sináptica se debe a la aparición de placas neuríticas y ovillos neurofibrilares a nivel cerebral, siendo estos elementos patológicos quienes repercuten en el desarrollo de la enfermedad y la diferencian de otros tipos de demencia, como la de origen vascular 4 . Esta enfermedad cursa con deterioro cognitivo, sin embargo, este se caracteriza por comprometer solamente el estado cognitivo del paciente, sin ser un estado de gravedad tal que implique un diagnóstico de demencia o EA 5 .El desarrollo de placas neuríticas está ligado al depósito extraneuronal de oligómeros de péptido beta-amiloide (Ab), originado a partir de la proteína precursora de amiloide (amyloid precursor protein, APP) ubicada a nivel de la membrana citoplasmática, la cual normalmente durante su proteólisis por las secretasas a, b y g, produce sustancias proteicas no tóxicas, pero en los pacientes con EA, debido a la acción de la secretasa b y g, se desencadena en mayor cuantía la producción del péptido Ab que posee efecto citotóxico (Figura 1). La placa neurítica es una estructura esférica que contiene Ab rodeada por neuritas distróficas, proteoglicanos, Apoe 4 , antiquimiotripsina a 1 y otras proteínas 4,[6][7][8][9][10][11] .

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“…Kişi bu çerçeveden uzaklaştıkça, işlevlerinin kusurlu hale geçişi mümkündür (14,15 (18). Diyette kalori kısıtlaması, başta Alzheimer olmak üzere, özellikle yaşla artan nörodejeneratif hastalıklara karşı koruyucu etkiye sahiptir (19). İstisna olarak sadece ALS'de diyette kalori kısıtlanması yerine diyet içeriğinde yağca zengin beslenme önerilmektedir (20,21).…”

Section: Beslenmenin Rolüunclassified

Beyi̇n Sağliğinda Beslenmeni̇n Etki̇si̇ / the Effect of the Nutrition on the Brain Health

Yildiz¹,

Dönderici²

2016

Osmangazi̇ Journal of Medicine

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ÖZET: Dünya'da ve ülkemizde yaşlanan nüfus ile birlikte, sağlıklı yaşlanmak ve beyin sağlığını korumak toplumların en öncelikli hedefi olmuştur. Bugün için insan sağlığını tehdit eden türlü çevresel etkilere karşın, bilim dünyasının sağlığı korumaya ve tedavi etmeye yönelik arayışları sürmektedir. Oksidatif stres olarak adlandırdığımız bu nedenlerin beynimizde yarattığı olumsuzluklar, hastalıkların da daha erken ve daha şiddetli ortaya çıkmasına neden olmaktadır. Tüm bu çevresel faktörler içinde kontrol edebileceğimiz en önemli etken ise beslenmemizdir. Bu noktada beyin sağlığının korunmasında beslenmemizin içeriği önem kazanmaktadır. Yaşamımızın her döneminde beslenmemizi önemsemeli, diyet içeriğimizin uzun ve sağlıklı bir yaşamın en önemli anahtarı olduğunu unutmamalıyız. Bu derlemede beyin sağlığı, çevresel etkenler ve beslenmenin rolü üzerine bir değerlendirme sunulmuştur.. ANAHTAR KELİMELER: Beyin, sağlık, oksidatif stres, beslenme THE EFFECT OF THE NUTRITION ON THE BRAIN HEALTHABSTRACT: Worldwide, it has become the primary goal of healthy aging to maintain brain health. Due to the the impact of any threat to human health, scientists continue to search for global health protection and treatment. Disadvantages caused by oxidative stress in the brain lead to an earlier emergence of diseases that are more severe. Of all of these factors, the most important environmental factors that we can control is our diet. The content of our diet is important in maintaining brain health. Care for our nutrition should be taken at every period of our life, and we should not forget that the most important key to a long and healthy life is the content of our diet. In this review, brain health is presented as an assessment of the role of environmental factors and nutrition.

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Dietary and lifestyle guidelines for the prevention of Alzheimer's disease

Cited by 284 publications

References 51 publications

Rauwolfia vomitoria and Gongronema latifolium extracts influences cerebellar cortex

Rauwolfia vomitoria and Gongronema latifolium extracts influences cerebellar cortex

Dieta mediterránea y sus efectos benéficos en la prevención de la enfermedad de Alzheimer

Beyi̇n Sağliğinda Beslenmeni̇n Etki̇si̇ / the Effect of the Nutrition on the Brain Health

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