Dietary and Non-dietary Phytochemicals in Cancer Control

Tailor, Dhanir; Singh, Rana P.

doi:10.1007/978-94-007-2923-0_24

Cited by 2 publications

(1 citation statement)

References 187 publications

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“…Table II details a list of phytochemicals that can induce CRC cell cycle arrest at different phases of the cell cycle (45,48,51,54,55,57,59,60,63–84). Phytochemicals are classified according to their chemical structure, for example, carotenoids, alkaloids and phenolic compounds such as flavonoids, phenolic acid, stilbenes (resveratrol), curcuminoids, tannins and cumarins (85). The following sections discuss the apoptotic mechanisms of different classes in detail.…”

Section: Apoptosis-inducing Phytochemicals In Crcmentioning

confidence: 99%

Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review)

et al. 2019

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Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fruits and vegetables have a significantly reduced incidence rate of CRC. This chemo-preventive effect is primarily associated with the presence of phytochemicals in the dietary components. Plant-derived chemical agents act as a prominent source of novel compounds for drug discovery. Phytochemicals have been the focus of an increasing number of studies due to their ability to modulate carcinogenic processes through the alteration of multiple cancer cell survival pathways. Despite promising results from experimental studies, only a limited number of phytochemicals have entered into clinical trials. The purpose of the current review is to compile previously published pre-clinical and clinical evidence of phytochemicals in cases of CRC. A PubMed, Google Scholar and Science Direct search was performed for relevant articles published between 2008–2018 using the following key terms: ‘Phytochemicals with colorectal cancers’, ‘apoptosis’, ‘cell cycle’, ‘reactive oxygen species’ and ‘clinical anticancer activities’. The present review may aid in identifying the most investigated phytochemicals in CRC cells, and due to the limited number of studies that make it from the laboratory bench to clinical trial stage, may provide a novel foundation for future research.

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Section: Apoptosis-inducing Phytochemicals In Crcmentioning

confidence: 99%

Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review)

et al. 2019

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Natural Products Possess Bioactive Agents Investigated for Their Anticancer Potential

Padma

Don

2022

Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics

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Cancer is regarded as a deadly disease and characterized as one of largest problems among the universal population. Worldwide, the population insists on a positive approach for curing the disease. However, plant resources are found to possess multiple phytochemicals which revealed promising effects for various cancer maladies. Over 60% of drugs are obtained from natural source only. Therapy for common cancer involves radiotherapy or chemotherapy, which alters the physical condition of the individual with diverse side effects and ultimately drains the immunity of the individual. Several available drugs are also unable to cure cancer completely, but recent advancement in utilization of plant-based compounds revealed greater beneficial efficacy in management of cancerous cell growth. Therefore, this chapter portrays the bioactive compounds obtained from natural sources and how these traditional medicines act as drug candidates against cancer.

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Dietary and Non-dietary Phytochemicals in Cancer Control

Cited by 2 publications

References 187 publications

Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review)

Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer (Review)

Natural Products Possess Bioactive Agents Investigated for Their Anticancer Potential

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