Dietary anthocyanins balance immune signs in osteoarthritis and obesity – update of human
            <i>in vitro</i>
            studies and clinical trials

Pomilio, Alicia B.; Szewczuk, Nicolas A; Duchowicz, Pablo R.

doi:10.1080/10408398.2022.2124948

Cited by 8 publications

(4 citation statements)

References 192 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gao et al [ 187 ] showed that anthocyanins from purple vegetables—purple cabbage, purple sweet potato, purple corn and Gynura bicolor —effectively inhibited the production of pro-inflammatory factors such as nitric oxide (NO) and tumour necrosis factor alpha (TNF-α) [ 187 ]. Anthocyanins have also been shown to counteract the progression of obesity and osteoarthritis [ 188 ]. Ngamsamer et al [ 189 ] highlighted the ability of anthocyanins to reduce markers of obesity-induced inflammation.…”

Section: The Effects Of Anthocyanins On the Prevention And Supportive...mentioning

confidence: 99%

“…In addition, blueberry, blackberry, cranberry and blackcurrant anthocyanins have been reported to inhibit inflammation in preadipocytes, which store low-grade inflammatory biomarkers associated with obesity [ 228 ]. Dietary anthocyanins have also been found to have beneficial effects on chronic inflammatory disorders such as intestinal diseases [ 188 ]. The antioxidant, anti-inflammatory and immunomodulatory properties of anthocyanins contribute to their anti-inflammatory effects [ 229 ].…”

Section: The Effects Of Anthocyanins On the Prevention And Supportive...mentioning

confidence: 99%

See 1 more Smart Citation

Effects of Anthocyanins on Components of Metabolic Syndrome—A Review

Godyla-Jabłoński,

Raczkowska,

Jodkowska

et al. 2024

Nutrients

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is a significant health problem. The co-occurrence of obesity, carbohydrate metabolism disorders, hypertension and atherogenic dyslipidaemia is estimated to affect 20–30% of adults worldwide. Researchers are seeking solutions to prevent and treat the conditions related to MetS. Preventive medicine, which focuses on modifiable cardiovascular risk factors, including diet, plays a special role. A diet rich in fruits and vegetables has documented health benefits, mainly due to the polyphenolic compounds it contains. Anthocyanins represent a major group of polyphenols; they exhibit anti-atherosclerotic, antihypertensive, antithrombotic, anti-inflammatory and anticancer activities, as well as beneficial effects on endothelial function and oxidative stress. This review presents recent reports on the mechanisms involved in the protective effects of anthocyanins on the body, especially among people with MetS. It includes epidemiological data, in vivo and in vitro preclinical studies and clinical observational studies. Anthocyanins are effective, widely available compounds that can be used in both the prevention and treatment of MetS and its complications. Increased consumption of anthocyanin-rich foods may contribute to the maintenance of normal body weight and modulation of the lipid profile in adults. However, further investigation is needed to confirm the beneficial effects of anthocyanins on serum glucose levels, improvement in insulin sensitivity and reduction in systolic and diastolic blood pressure.

show abstract

Section: The Effects Of Anthocyanins On the Prevention And Supportive...mentioning

confidence: 99%

Section: The Effects Of Anthocyanins On the Prevention And Supportive...mentioning

confidence: 99%

Effects of Anthocyanins on Components of Metabolic Syndrome—A Review

Godyla-Jabłoński,

Raczkowska,

Jodkowska

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…The value of anthocyanins in protecting against the progression of OA and obesity has been comprehensively demonstrated ( 123 ). Cyanidin, one of the main anthocyanins, has been reported to have anti-inflammatory activity.…”

Section: Natural Flavonoids Exhibit Protective Activity Against Oa De...mentioning

confidence: 99%

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

Zhou

2023

Front. Endocrinol.

View full text Add to dashboard Cite

Osteoarthritis (OA) is a typical joint disease associated with chronic inflammation. The nuclear factor-kappaB (NF-κB) pathway plays an important role in inflammatory activity and inhibiting NF-κB-mediated inflammation can be a potential strategy for treating OA. Flavonoids are a class of naturally occurring polyphenols with anti-inflammatory properties. Structurally, natural flavonoids can be divided into several sub-groups, including flavonols, flavones, flavanols/catechins, flavanones, anthocyanins, and isoflavones. Increasing evidence demonstrates that natural flavonoids exhibit protective activity against the pathological changes of OA by inhibiting the NF-κB signaling pathway. Potentially, natural flavonoids may suppress NF-κB signaling-mediated inflammatory responses, ECM degradation, and chondrocyte apoptosis. The different biological actions of natural flavonoids against the NF-κB signaling pathway in OA chondrocytes might be associated with the differentially substituted groups on the structures. In this review, the efficacy and action mechanism of natural flavonoids against the development of OA are discussed by targeting the NF-κB signaling pathway. Potentially, flavonoids could become useful inhibitors of the NF-κB signaling pathway for the therapeutic management of OA.

show abstract

“…The use of phytochemicals in the treatment of inflammatory diseases has become an emerging trend due to their recognized biological activities and low intrinsic toxicity. Some flavonoids have shown promise in the treatment of sepsis (Chen, Luo, et al, 2022) and osteoarthritis (Pomilio et al, 2022) by inhibiting pyroptosis. Apigenin (API), a classical flavonoid found in parsley, garlic, and chamomile, is well known for its excellent anti‐inflammatory and antioxidative activities, which contribute to its numerous pharmacological applications, such as antitumor and cardiovascular protection (Xu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the NF‐κB pathway and ameliorates atherosclerosis

Weng

Luo

Dai

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Pyroptosis plays an important role in inflammatory diseases such as viral hepatitis and atherosclerosis. Apigenin exhibits various bioactivities, particularly anti‐inflammation, but its effect on pyroptosis remains unclear. The aim of this study is to investigate the effect of apigenin on pyroptosis and explore its potential against inflammatory diseases. THP‐1 macrophages treated by lipopolysaccharides/adenosine 5′‐triphosphate were used as the in vitro pyroptosis model. Western blot was used to detect the expression of NLRP3 inflammasome components and key regulators. Immunofluorescence was used to observe ROS production and intracellular location of p65. The potential of apigenin against inflammatory diseases was evaluated using atherosclerotic mice. Plaque progression was observed by pathological staining. Immunofluorescence was used to observe the expression of NLRP3 inflammasome components in plaques. The results showed that apigenin inhibited NLRP3 inflammasome activation. Apigenin reduced ROS overproduction and inhibited p65 nuclear translocation. Additionally, apigenin decreased the expression of NLRP3 inflammasome components in the plaque. Plaque progression was inhibited by apigenin. In conclusion, apigenin exhibited a preventive effect on macrophage pyroptosis by reducing oxidative stress and inhibiting the NF‐κB pathway. Apigenin may alleviate atherosclerosis at least partially by inhibiting macrophage pyroptosis. These findings suggest apigenin to be a promising therapeutic agent for inflammatory diseases.

show abstract

Dietary anthocyanins balance immune signs in osteoarthritis and obesity – update of human in vitro studies and clinical trials

Cited by 8 publications

References 192 publications

Effects of Anthocyanins on Components of Metabolic Syndrome—A Review

Effects of Anthocyanins on Components of Metabolic Syndrome—A Review

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the NF‐κB pathway and ameliorates atherosclerosis

Contact Info

Product

Resources

About