Dietary antioxidant intake and the risk of developing Barrett’s oesophagus and oesophageal adenocarcinoma

Kang, James Hong-En; Luben, Robert; Alexandre, Leo; Hart, Andrew

doi:10.1038/s41416-018-0113-y

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…Vc is one of the commonly used antioxidants. Several studies have demonstrated that Vc can decrease the risk of developing gastrointestinal diseases via reducing oxidative stress response 50,51 . In the present study, we found that rats given Vc had higher contents of CAT and SOD, as well as a higher mRNA expression level of GCLC.…”

Section: Discussionsupporting

confidence: 66%

“…Several studies have demonstrated that Vc can decrease the risk of developing gastrointestinal diseases via reducing oxidative stress response. 50,51 In the present study, we found that rats given Vc had higher contents of CAT and SOD, as well as a higher mRNA expression level of GCLC. Meanwhile, the administration of Vc increased the protein expression levels of p-Nrf2, p-p38 and JNK.…”

Section: Discussionsupporting

confidence: 64%

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Regulation of wheat bran feruloyl oligosaccharides in the intestinal antioxidative capacity of rats associated with the p38/JNK‐Nrf2 signaling pathway and gut microbiota

et al. 2022

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BACKGROUND Feruloyl oligosaccharides (FOs), the ferulic acid ester of oligosaccharides, may possess the physiological functions of both ferulic acid and oligosaccharides, including antioxidative activity and gut microbiota modulation capacity. The present study aimed to investigate whether FOs could regulate the intestinal antioxidative capacity of rats by modulating the MAPKs/Nrf2 signaling pathway and gut microbiota. Thirty Wistar rats were randomly divided into five groups. Rats received a standard diet and were gavaged once daily with 0.85% normal saline, 100 mg kg−1 body weight vitamin C or FOs solution at doses of 20, 40 and 80 mg kg−1 body weight for 21 days. RESULTS FOs strengthened the antioxidative capacity of the jejunum, as indicated by increased in contents of catalase, superoxide dismutase and glutathione peroxidase, as well as glutathione. Moreover, FOs administration upregulated the mRNA expression level of antioxidant‐related genes (glutamate‐cysteine ligase catalytic subunit, glutamate‐cysteine ligase modifier subunit and heme oxygenase‐1) in the jejunum. Increases in phosphorylation levels of Nrf2, p38 and JNK were also observed. Administration with 40 mg kg−1 FOs altered the structure and composition of the cecal microbiota, which was indicated by the increased the relative abundances of Actinobacteria, Proteobacteria and Acidobacteriota, and the decreased the relative abundances of Firmicutes, Lachnospiraceae_NK4A136_group and Blautia. Furthermore, Spearman correlation analysis revealed that the altered cecal microbiota closely correlated with jejunal antioxidative capacity of rats. CONCLUSION FOs could be used as an antioxidant for gut heath improvement through modulating the p38/JNK‐Nrf2 signaling pathway and gut microbiota. © 2022 Society of Chemical Industry.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionsupporting

confidence: 64%

Regulation of wheat bran feruloyl oligosaccharides in the intestinal antioxidative capacity of rats associated with the p38/JNK‐Nrf2 signaling pathway and gut microbiota

et al. 2022

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“…This is because cancer cells have redox regulation genes, suggesting that low ROS levels are required for their survival; however, the therapeutic approach may be crucial to treating this pathology. Nevertheless, in clinical trials has been shown that antioxidant consumption might be beneficial [ 167 , 168 , 169 , 170 , 171 , 172 ] or have no effect [ 167 , 172 , 173 , 174 ], as it is suggested to depend on the metabolic demand of the individual.…”

Section: Inflammation In Cancermentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs

et al. 2023

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Food is our daily companion, performing numerous beneficial functions for our bodies. Many of them can help to alleviate or prevent ailments and diseases. In this review, an extensive bibliographic search is conducted in various databases to update information on unprocessed foods with anti-inflammatory and antioxidant properties that can aid in treating diseases such as cancer. The current state of knowledge on inflammatory processes involving some interleukins and tumor necrosis factor-alpha (TNF-α) is reviewed. As well as unprocessed foods, which may help reduce inflammation and oxidative stress, both of which are important factors in cancer development. Many studies are still needed to take full advantage of the food products we use daily.

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“…[ 7 ] Currently, vitamin C (Vc) is the most commonly used supplement for OSD clinical therapy. Several studies have demonstrated that the intake of Vc can reduce the risk of developing digestive system diseases [ 8‐9 ] and reduce liver damage by regulating the oxidative stress response. [ 10 ] However, the long‐term or incorrect intake of Vc supplement is associated with several side effects, such as increased gastric acid production, [ 11 ] poor oral utilization, and increased risk of developing kidney stones.…”

Section: Introductionmentioning

confidence: 99%

Lonicera caerulea L. Polyphenols Alleviate Oxidative Stress‐Induced Intestinal Environment Imbalance and Lipopolysaccharide‐Induced Liver Injury in HFD‐Fed Rats by Regulating the Nrf2/HO‐1/NQO1 and MAPK Pathways

Cheng

Sun

et al. 2020

Molecular Nutrition Food Res

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Scope: This study investigates the modulatory effects of Lonicera caerulea L. polyphenols (LCPs) on the intestinal environment and lipopolysaccharide (LPS)-induced liver injury via the nuclear factor erythroid-2-related factor 2/heme oxygenase-1 (HO-1)/NQO1 and mitogen-activated protein kinase (MAPK) pathways in a rat model of oxidative stress damage (OSD). Methods and results: To examine the prebiotic properties of LCP, a model of high-fat-diet-induced OSD is established using Sprague Dawley rats. In the colon, treatment with LCP for 8 weeks ameliorates enhanced intestinal permeability (glucagon-like peptide-2 content and occludin protein increase, whereas claudin-2 protein decreases), intestinal inflammation (levels of pro-inflammatory cytokines, such as tumor necrosis factor-, interleukin-6, cyclooxygenase-2, and nuclear factor kappa-B p65 (NF-B p65), decrease), and intestinal OSD (through regulation of the Nrf2/HO-1/NQO1 pathway). Moreover, LCP alleviates LPS-induced liver injury by suppressing the nuclear translocation of NF-B p65 and activation of the MAPK signaling pathway. Additionally, Bacilli, Lactobacillales, Lactobacillaceae, Lactobacillus, Akkermansia, Actinobacteria, Proteobacteria, Rothia, and Blautia are found to be the key intestinal microbial taxa related to intestinal OSD and LPS-induced liver injury in rats. Conclusion: LCP treatment potentially modulates the intestinal environment and alleviates liver injury by suppressing oxidative-stress-related pathways and altering the composition of the intestinal microbiota.

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Dietary antioxidant intake and the risk of developing Barrett’s oesophagus and oesophageal adenocarcinoma

Abstract: Data supports a role for dietary antioxidants prevent BO and OAC, perhaps at the earlier stages of carcinogenesis.

Cited by 9 publications

References 15 publications

Regulation of wheat bran feruloyl oligosaccharides in the intestinal antioxidative capacity of rats associated with the p38/JNK‐Nrf2 signaling pathway and gut microbiota

Regulation of wheat bran feruloyl oligosaccharides in the intestinal antioxidative capacity of rats associated with the p38/JNK‐Nrf2 signaling pathway and gut microbiota

Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs

Lonicera caerulea L. Polyphenols Alleviate Oxidative Stress‐Induced Intestinal Environment Imbalance and Lipopolysaccharide‐Induced Liver Injury in HFD‐Fed Rats by Regulating the Nrf2/HO‐1/NQO1 and MAPK Pathways

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