Dietary Antioxidants and Asthma in Adults

Shaheen, Seif O.; Sterne, Jonathan A C; Thompson, Rachel; Songhurst, Christina E; Margetts, Barrie; Burney, Peter

doi:10.1164/ajrccm.164.10.2104061

Cited by 260 publications

(70 citation statements)

References 48 publications

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“…In our sample, however, no effects of antioxidant (vitamins C, E, A, b-carotene) intake or of the consumption of antioxidant-providing food groups such as fruit (eg apples) intake, as potential dietary source of flavonoids, or meat intake, as potential source for selenium on asthma risk, were observed. This is consistent with observations of Woods et al (2003), whereas Shaheen et al (2001) observed an inverse association between apple consumption and selenium intake and asthma.…”

Section: Discussionsupporting

confidence: 92%

Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults

Nagel

Linseisen

2004

Eur J Clin Nutr

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Objective: Within a prospective study, we explored the associations between dietary intake of fatty acids, antioxidants and relevant food sources of these nutrients on the clinical manifestation of asthma in adulthood. Method: A total of 105 newly physician-diagnosed cases of asthma from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort were identified during follow-up and matched with 420 controls. Baseline dietary intake was obtained by means of validated food frequency questionnaires. The association of dietary intake variables and asthma risk was explored by unconditional logistic regression models. Results: A high intake of oleic acid (C18:1 n-9) was positively associated with asthma (P-value for trend 0.035), while no significant associations were found for the other dietary fatty acids. Most prominently, a high margarine intake increased the risk of onset of asthma in adulthood (adjusted odds ratio (OR) 3rd tertile: 1.73 (95% confidence interval (95% CI): 1.05-2.87), P for trend ¼ 0.050), the effect being stronger in men (2nd tertile: OR ¼ 1.66, 3rd tertile: OR ¼ 2.51) than in women (2nd tertile: OR ¼ 0.91; 3rd tertile: OR ¼ 1.47). The dietary intake of antioxidants and their main food sources had no effect on asthma risk. Conclusions: In summary, the present results provide evidence that even in adulthood a high margarine intake increases the risk of clinical onset of asthma. Whether oleic acid may serve as a proxy for margarine-derived trans-fatty acids (C18:1 t9) remains to be clarified.

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Section: Discussionsupporting

confidence: 92%

Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults

Nagel

Linseisen

2004

Eur J Clin Nutr

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“…Whether the worldwide increase in the prevalence of allergic diseases is directly associated with diet is unknown, but a recently reported population-based case-control study found that consumption of apples or red wine was negatively associated with asthma prevalence or severity, respectively, possibly due to the protective effect of flavonoids [24]. In addition, a cohort study in Finland demonstrated a lower asthma incidence for higher total flavonoid intakes (relative risk = 0.65, p = 0.04), mainly in the form of apples and oranges [25].…”

Section: Discussionmentioning

confidence: 99%

Flavonoids such as Luteolin, Fisetin and Apigenin Are Inhibitors of Interleukin-4 and Interleukin-13 Production by ActivatedHuman Basophils

Hirano

Higa²,

Arimitsu³

et al. 2004

Int Arch Allergy Immunol

124

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Background: We have previously shown that fisetin, a flavonol, inhibits IL-4 and IL-13 synthesis by allergen- or anti-IgE-antibody-stimulated basophils. This time, we investigated the inhibition of IL-4 and IL-13 production by basophils by other flavonoids and attempted to determine the fundamental structure of flavonoids related to inhibition. We additionally investigated whether flavonoids suppress leukotriene C4 synthesis by basophils and IL-4 synthesis by T cells in response to anti-CD3 antibody. Methods: Highly purified peripheral basophils were stimulated for 12 h with anti-IgE antibody alone or anti-IgE antibody plus IL-3 in the presence of various concentrations of 18 different kinds of flavones and flavonols. IL-4 and IL-13 concentrations in the supernatants were then measured. Leukotriene C4 synthesis was also measured after basophils were stimulated for 1 h in the presence of flavonoids. Regarding the inhibitory activity of flavonoids on IL-4 synthesis by T cells, peripheral blood mononuclear cells were cultured with flavonoids in anti-CD3-antibody-bound plates for 2 days. Results: Luteolin, fisetin and apigenin were found to be the strongest inhibitors of both IL-4 and IL-13 production by basophils but did not affect leukotriene C4 synthesis. At higher concentrations, these flavonoids suppressed IL-4 production by T cells. Based on a hierarchy of inhibitory activity, the basic structure for IL-4 inhibition by basophils was determined. Conclusions: Due to the inhibitory activity of flavonoids on IL-4 and IL-13 synthesis, it can be expected that the intake of flavonoids, depending on the quantity and quality, may ameliorate allergic symptoms or prevent the onset of allergic diseases.

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“…58 With regard to asthma, a protective relationship was found between dietary Se intake and asthma in adults in a large population-based case-control study in London (OR 0.84 per quintile increase; 95% CI 0.75-0.94; P = 0.002). 59 In a small nested case-control study, current wheeze among New Zealand children was found to be more common in those with low levels of Se in serum samples collected eight-years previously (OR 3.1; 95% CI 0.9-11.8). 60 Another small study in intrinsic asthmatics showed significant clinical improvement upon supplementation with Se at 100mcg/d as sodium selenite.…”

Section: Thyroid Functionmentioning

confidence: 99%