Dietary Aronia melanocarpa Pomace Supplementation Enhances the Expression of ZO-1 and Occludin and Promotes Intestinal Development in Pigs

Ren, Zhongshuai; Fang, Hengtong; Zhang, Jing; Wang, Rui; Xiao, Wenyu; Zheng, Kexin; Yu, Hao; Zhao, Yun

doi:10.3389/fvets.2022.904667

Cited by 9 publications

(8 citation statements)

References 52 publications

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“…Commonly, a greater serum TC concentration means a higher risk of cardio-cerebrovascular disease in mammal. Our results showed that the TC was lesser in 1.5% and 2.0% SBP groups and HDL was greater in 2.0% SBP group, which in agreement with a previous study on pig offered Aronia melanocarpa Pomace (Ren et al, 2022). The AST and ALT, as the important indicators that reflect liver damage, were increased as the liver was damaged (Schomaker et al, 2020).…”

Section: Serum Metabolites Indexessupporting

confidence: 92%

Effects of sea buckthorn pomace on growth performance, serum metabolites and antioxidant indexes of growing pigs

Yan,

Liang,

Ding

et al. 2023

Sem. Ci. Agr.

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Sea buckthorn pomace (SBP), an agro-industrial waste, containing useful nutrition compounds for animal production. This study aimed to evaluate the effect of growth performance and serum metabolisms in growing pig when consumed SBP. A total of 40 crossbred 70-day-old growing pig with initial body weight (IBW; 30 ±1.5 kg) were randomly assigned to 4 groups. The pigs were fed dietary supplementation of SBP (0.0%, 0.5, 1.5%, and 2.0 %) for 30 d. It concluded that the appropriate level of 1.5% SBP supplementation could improve pig growth performance. Serum immune and antioxidant indexes performed best in 1.5% SBP supplementation group. We suggested that the appropriate level of SBP supplementation would be 1.5% for growing pig, which could improve their growth performance, serum immune and antioxidant indexes.

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Section: Serum Metabolites Indexessupporting

confidence: 92%

Effects of sea buckthorn pomace on growth performance, serum metabolites and antioxidant indexes of growing pigs

Yan,

Liang,

Ding

et al. 2023

Sem. Ci. Agr.

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“…Additionally, villus height and crypt depth are two common indices used to assess broilers intestinal integrity. Increased villus height indicates increased surface area for nutrient absorption, whereas increased crypt depth indicates rapid tissue turnover, which is typically associated with decreased nutrient digestion and absorption capacity 33 . In this study, the group provided MHA-Zn (90 mg/kg) had a significantly increased ileal villus height and decreased crypt depth in ileum compared with other groups.…”

Section: Discussionmentioning

confidence: 99%

Effects of organic zinc on production performance, meat quality, apparent nutrient digestibility and gut microbiota of broilers fed low-protein diets

Dong

Zhang

et al. 2023

Sci Rep

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The high cost of feed and nitrogen pollution caused by high-protein diets have become major challenges restricting sustainable development in China's animal husbandry sector. Properly reducing protein levels and improving protein utilization in feed are effective approaches to solving this problem. To determine the optimal dose of methionine hydroxyl analogue chelated zinc (MHA-Zn) in broiler diets with a 1.5% reduction in crude protein (CP), a total of 216 1-day-old broilers were randomly assigned into 4 groups (each group consisted of 3 replications with 18 broilers per replicate), and growth and development indexes were assessed after 42 days. The broilers in control group were fed a basic diet, whereas those in the three test groups were fed diets with a 1.5% reduction in CP. The results showed no significant difference in the edible parts of broilers between low-protein (LP) diet group (90 mg/kg MHA-Zn) and normal diet group (p > 0.05), and adding 90 mg/kg MHA-Zn to LP diet significantly improved ileum morphology and apparent total tract digestibility (ATTD) of nutrient (p < 0.01; p < 0.05). A 16S rRNA sequencing analysis indicated that supplementing the LP diet with 90 mg/kg MHA-Zn was adequate for production performance of broilers and promoted beneficial bacteria in the cecum (Lactobacillus, Butyricoccus, Oscillospira, etc.) (p < 0.01). In summary, adding an optimal dose of organic zinc (90 mg/kg MHA-Zn) in low protein diets led to enhanced production performance of broilers and optimized cecum microbiota. Additionally, the reduction of crude protein consumption in broiler production proved to be a cost-effective measure, while also mitigated nitrogen pollutant emissions in the environment.

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“…Here, dietary supplementation with CTC or 10-HDA effectively reduced the LPS-induced elevation of serum DAO levels. Moreover, intestinal tight junction proteins play key roles in the formation of the intestinal selective permeability barrier, contributing to maintaining the integrity of the intestinal structure ( Ren et al, 2022 ). We found that supplementation with CTC or 10-HDA could ameliorate the downregulation of ZO-1 and OCLN expression in the chickens’ jejunum induced by LPS.…”

Section: Discussionmentioning

confidence: 99%

10-hydroxy-2-decenoic acid alleviates lipopolysaccharide-induced intestinal mucosal injury through anti-inflammatory, antioxidant, and gut microbiota modulation activities in chickens

Han,

Zhang,

et al. 2023

Front. Microbiol.

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IntroductionThis study aimed to investigated the effects of 10-hydroxy-2-decenoic acid (10-HDA) on the growth performance, intestinal barrier, inflammatory response, oxidative stress, and gut microbiota of chickens challenged with lipopolysaccharide (LPS).MethodsA total of 240 one-day-old chickens were randomly assigned to five treatment groups: (1) control group (basal diet + saline); (2) LPS group (basal diet + LPS); (3) Chlortetracycline (CTC) group (basal diet containing 75 mg/kg CTC + LPS); (4) 0.1% 10-HDA group (basal diet containing 1 g/kg 10-HDA + LPS); and (5) 0.5% 10-HDA group (basal diet containing 5 g/kg 10-HDA + LPS). All chickens were injected intraperitoneally with 0.5 mg/kg body weight of either LPS or saline at 17, 19, and 21 days of age.ResultsThe results showed that dietary 10-HDA supplementation attenuated the loss in growth performance caused by the LPS challenge (p < 0.05). 10-HDA effectively alleviated LPS-induced intestinal mucosal injury, as evidenced by reduced bleeding, decreased serum diamine oxidase levels (p < 0.05), and increased villus/crypt ratios of the jejunum and ileum (p < 0.05). Dietary treatment with 0.1% 10-HDA reduced the concentrations of inflammatory cytokines (TNF-α, IL-1β, IL-6; p < 0.05), and increased immunoglobulin (IgA, IgG) and antioxidant enzyme levels (CAT, GSH-px, T-SOD) in the serum of LPS-challenged chickens (p < 0.05). These effects were similar to those observed in the CTC group. Moreover, 0.1% 10-HDA treatment reversed the LPS-induced variations in the mRNA expression of genes related to inflammation, antioxidant capacity, and intestinal tight junctions (p < 0.05). 16S rRNA analysis revealed that 10-HDA supplementation increased the relative abundance of Faecalibacterium and Clostridia_UCG-014 (p < 0.05). Additionally, it decreased the abundance of Clostridia_vadinBB60_group, Eubacterium_nodatum_group, and UC5-1-2E3 (p < 0.05). These changes were correlated with reduced inflammation and improved antioxidant capacity in the LPS-challenged chickens.ConclusionCollectively, dietary 10-HDA supplementation alleviated LPS-induced intestinal mucosal injury and the loss of growth performance through anti-inflammatory, antioxidant, and gut microbiota modulation activities in chickens. Moreover, 0.1% 10-HDA supplementation had comparable or even better protection for LPS-challenged chickens than supplementation with antibiotics or 0.5% 10-HDA. 10-HDA has the potential to be used as an alternative to antibiotics in protecting the intestinal health and improving the performance of poultry.

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Dietary Aronia melanocarpa Pomace Supplementation Enhances the Expression of ZO-1 and Occludin and Promotes Intestinal Development in Pigs

Cited by 9 publications

References 52 publications

Effects of sea buckthorn pomace on growth performance, serum metabolites and antioxidant indexes of growing pigs

Effects of sea buckthorn pomace on growth performance, serum metabolites and antioxidant indexes of growing pigs

Effects of organic zinc on production performance, meat quality, apparent nutrient digestibility and gut microbiota of broilers fed low-protein diets

10-hydroxy-2-decenoic acid alleviates lipopolysaccharide-induced intestinal mucosal injury through anti-inflammatory, antioxidant, and gut microbiota modulation activities in chickens

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