Dietary astaxanthin-rich extract ameliorates atherosclerosis/retinopathy and restructures gut microbiome in apolipoprotein E-deficient mice fed on a high-fat diet

Liu, Dong; Ji, Yanglin; Chen, Qian; Zhu, Yamin; Zhang, Haibo; Guo, Yatu; Cao, Xiupeng; Wang, Hao

doi:10.1039/d2fo02102a

Cited by 4 publications

(2 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LefSE analysis identified that Akkermansia was the only bacteria with a relative abundance change exceeding 1% in the AX group compared to the HFD group. Numerous studies had reported a growth of Akkermansia following AX supplementation [ 37 , 38 , 62 ]. A decreased abundance of Akkermansia was associated with various diseases such as obesity, diabetes and liver steatosis, while Akkermansia supplementation exhibited anti-obesity effects and improve metabolic disorders induced by HFD [ 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

“…An improved strategy targeting gut dysbiosis could help reduce inflammation and rescue muscle strength [36]. Studies have confirmed the probiotic and anti-gut inflammatory properties of AX in mice fed HFD [37][38][39]. Gut microbiota plays a crucial role in connecting food intervention with disease improvement, as it can be directly influenced by diet.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota

Chen,

Ling,

Chen

et al. 2023

Nutrients

View full text Add to dashboard Cite

Duchenne muscular dystrophy (DMD), a severe X-linked inherited neuromuscular disease, has a high prevalence of obesity. Obesity exacerbates muscle damage and results in adverse clinical outcomes. Preventing obesity helps DMD patients delay disease progression and improve quality of life. Astaxanthin (AX) is a kind of carotenoid which has antioxidant and anti-adipogenesis effects. In this study, male C57BL/10ScSnDmdmdx/J mice were fed with a normal diet, a high-fat diet (HFD), and an HFD containing AX for 16 weeks, respectively. The results showed that AX significantly increased gastrocnemius fiber cross-section area and grip strength, improved treadmill endurance test and mitochondrial morphology, and reduced muscle triglyceride and malonaldehyde levels compared to the HFD. Lipidomic analysis revealed that AX decreased high levels of triglyceride, diglyceride, ceramides, and wax ester induced by HFD. Gut microbiota analysis indicated that AX supplementation failed to alleviate abnormal microbiota diversity, but increased the relative abundances of Akkermansia, Bifidobacterium, Butyricicoccus, and Staphylococcus. In conclusion, AX was expected to alleviate disease progression associated with obesity in DMD patients by reducing lipotoxicity and increasing the abundance of beneficial bacteria.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota

Chen,

Ling,

Chen

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

Astaxanthin alleviates chronic prostatitis/chronic pelvic pain syndrome by increasing colonization of Akkermansia muciniphila in the intestine

Liu,

Xie,

et al. 2024

Phytomedicine

View full text Add to dashboard Cite

Caveolin and NOS in the Development of Muscular Dystrophy

Nakashima,

Suga,

Yoshikawa

et al. 2024

IJMS

View full text Add to dashboard Cite

Caveolin is a structural protein within caveolae that may be involved in transmembrane molecular transport and/or various intercellular interactions within cells. Specific mutations of caveolin-3 in muscle fibers are well known to cause limb–girdle muscular dystrophy. Altered expression of caveolin-3 has also been detected in Duchenne muscular dystrophy, which may be a part of the pathological process leading to muscle weakness. Interestingly, it has been shown that the renovation of nitric oxide synthase (NOS) in sarcolemma with muscular dystrophy could improve muscle health, suggesting that NOS may be involved in the pathology of muscular dystrophy. Here, we summarize the notable function of caveolin and/or NOS in skeletal muscle fibers and discuss their involvement in the pathology as well as possible tactics for the innovative treatment of muscular dystrophies.

show abstract

Dietary astaxanthin-rich extract ameliorates atherosclerosis/retinopathy and restructures gut microbiome in apolipoprotein E-deficient mice fed on a high-fat diet

Abstract: Scope: Atherosclerosis (AS) is the leading cause of ischemic disease. However, the anti-AS effects of astaxanthin and its potential mechanisms remain unclear. This study aimed to investigate the function of...

Cited by 4 publications

References 73 publications

Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota

Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota

Astaxanthin alleviates chronic prostatitis/chronic pelvic pain syndrome by increasing colonization of Akkermansia muciniphila in the intestine

Caveolin and NOS in the Development of Muscular Dystrophy

Contact Info

Product

Resources

About