Dietary bioactive peptides: Human studies

Bouglé, Dominique; Bouhallab, Saı̈d

doi:10.1080/10408398.2013.873766

Cited by 115 publications

(65 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is easy to predict the cleavage of peptides by the primary digestive enzymes using in silico method, whereas transport and stability is hard to elucidate. It has been generally claimed that small peptides (<6 residues) are able to pass enterocyte, with the absorption efficiency decreasing as peptide length prolongs (Bouglé & Bouhallab, ).…”

Section: Structure–bioavailability Relationship Of Acei Peptidesmentioning

confidence: 99%

Molecular interactions, bioavailability, and cellular mechanisms of angiotensin-converting enzyme inhibitory peptides

2018

View full text Add to dashboard Cite

Food-derived angiotensin-converting enzyme inhibitory (ACEi) peptides have gained substantial interest as potential alternatives to synthetic drugs in the management of hypertension. Peptide size and sequence are two critical factors that determine their potency, bioavailability, and cellular mechanisms. Molecular interaction studies between ACE and ACEi peptides support that potent ACEi peptides are generally composed of hydrophobic, positively charged, and aromatic or cyclic amino acid residues at the third, second, and first position from the C-terminus, respectively. Small peptides containing N-terminal Tyr and/or C-terminal Pro could improve their stability against enterocyte peptidases and, thus, their bioavailability. Different ACEi peptides can reduce aberrant cellular proliferation, excessive inflammation, and oxidative stress but through different mechanisms. Further understanding the structure-activity-bioavailability relationships will help design novel potent ACEi peptides with improved bioavailability and in vivo efficacy. Practical applicationsAngiotensin-converting enzyme inhibitory peptides have the potential for uses as functional food ingredients against hypertension. K E Y W O R D S angiotensin-converting enzyme, angiotensin-converting enzyme inhibitory peptides, bioavailability, cellular mechanisms, molecular docking, vascular endothelial cells, vascular smooth muscle cells J Food Biochem. 2019;43:e12572.

show abstract

Section: Structure–bioavailability Relationship Of Acei Peptidesmentioning

confidence: 99%

Molecular interactions, bioavailability, and cellular mechanisms of angiotensin-converting enzyme inhibitory peptides

2018

View full text Add to dashboard Cite

show abstract

“…Most anti‐inflammatory properties of food‐derived bioactive peptides are assessed on experimental and in vitro and in vivo animal studies but rarely affirmed in human trials. Bioactive peptides from food have been noted to alter the production of pro‐inflammatory interleukins, free radicals, and prostaglandins ex vivo (Bouglé & Bouhallab, ). For instance, Zenk et al reported decrease in the activity score of osteoarthritis upon ingestion of 2 g milk protein concentrate (Zenk, Helmer, & Kuskowski, ).…”

Section: Conclusion and Future Prospective Studiesmentioning

confidence: 99%

Structural-features of food-derived bioactive peptides with anti-inflammatory activity: A brief review

2018

View full text Add to dashboard Cite

Chronic inflammatory conditions such as obesity, type-2 diabetes, and cardiovascular diseases are the leading causes of mortality worldwide. Hence, much research interest in bioactive peptides has been stimulated due to lack of potent pharmacological interventions. Although many such peptides have been identified from food proteins, insufficient information is available on their structurefunction relationship. Presence of hydrophobic and positively charged amino acids is a common occurrence for the peptides with anti-inflammatory properties. However, inconsistent findings have also been reported. Most of the food-derived peptides exhibited their anti-inflammatory activities primarily by inhibiting signaling components of either NF-jB or MAPK pathway, which are the two major pathways involved in chronic inflammation following uncontrolled signal activation. This review highlighted the structural requirements of the peptides to exhibit antiinflammatory activity based on the current knowledge about food-derived anti-inflammatory peptides and their underlying molecular mechanisms of action. Practical applicationsWhile research in the food-derived bioactive peptide is gaining momentum, but the ability to translate these new findings into the commercial product such as nutraceuticals and functional foods, remains delayed. The most prominent reasons for this delay are the lack of detailed research on, (i) the structure-function relationship of the peptide and the underlying molecular mechanisms of these bioactive peptides, and (ii) the interaction of these peptides with different cellular elements in the disease pathophysiology. This review gives an insight into the structure-activity relationship of bioactive peptides involved in anti-inflammatory responses. The information provided here would be highly beneficial to describe the possible anti-inflammatory activity of any newly identified peptides from different food sources. K E Y W O R D Santi-inflammation, bioactive peptides, food proteins, inflammatory responses, structure-function relationships

show abstract

“…Few clinical trials have been conducted involving peptides and cancer (Gustafsson et al, 2004). Some synthetized peptides derived from seaproducts are being tested in phase II trials, these include: BioPep, Plitidepsin, Elisidepsin, and Tasidotin (Bouglé and Bouhallab, 2017). Even so this studies indicate that there is an enormous potential in the bioactivity of peptides derived from foods for the prevention and/or treatment of cancer.…”

Section: Therapeutic Perspectives and Conclusionmentioning

confidence: 99%

Anti-Cancer Activity of Maize Bioactive Peptides

et al. 2017

View full text Add to dashboard Cite

Cancer is one of the main chronic degenerative diseases worldwide. In recent years, consumption of whole-grain cereals and their derivative food products has been associated with a reduced risk of various types of cancer. The main biomolecules in cereals include proteins, peptides, and amino acids, all of which are present in different quantities within the grain. Some of these peptides possess nutraceutical properties and exert biological effects that promote health and prevent cancer. In this review, we report the current status and advances in knowledge regarding the bioactive properties of maize peptides, such as antioxidant, antihypertensive, hepatoprotective, and anti-tumor activities. We also highlight the potential biological mechanisms through which maize bioactive peptides exert anti-cancer activity. Finally, we analyze and emphasize the potential applications of maize peptides.

show abstract

Dietary bioactive peptides: Human studies

Cited by 115 publications

References 90 publications

Molecular interactions, bioavailability, and cellular mechanisms of angiotensin-converting enzyme inhibitory peptides

Molecular interactions, bioavailability, and cellular mechanisms of angiotensin-converting enzyme inhibitory peptides

Structural-features of food-derived bioactive peptides with anti-inflammatory activity: A brief review

Anti-Cancer Activity of Maize Bioactive Peptides

Contact Info

Product

Resources

About