Dietary branched-chain amino acids intake exhibited a different relationship with type 2 diabetes and obesity risk: a meta-analysis

Okekunle, Akinkunmi Paul; Zhang, Meng; Wang, Zhen; Onwuka, Justina Ucheojor; Wu, Xiaoyan; Feng, Rennan; Li, Chunlong

doi:10.1007/s00592-018-1243-7

Cited by 34 publications

(22 citation statements)

References 54 publications

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“…Another cross-sectional study demonstrated that obese subjects, compared with non-obese individuals, had lower intakes of dietary BCAAs (24). In a recent meta-analysis, a contra-positive correlation between BCAAs intake and risk of obesity was found (10). Different ndings might be explained by methodological discrepancies across studies including difference in target population, dietary assessment tools, and controlling for confounding factors in the analyses.…”

Section: Discussionmentioning

confidence: 98%

“…Another cross-sectional study demonstrated a positive relationship between BCAAs and visceral adipose tissue and insulin resistance. Some studies have revealed that dietary intake of BCAAs was associated with increased circulating levels of these amino acids (10). Lu et al in a cross-sectional study investigated that increased BCAAs intake is associated with increased risk of insulin resistance and obesity in children (11).…”

Section: Introductionmentioning

confidence: 99%

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Dietary intake of branched-chain amino acids in relation to general and abdominal obesity

et al. 2021

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Purpose: Despite the huge evidence on the link between dietary protein intake and obesity, limited studies have examined the role of individual amino acids in this regard. This study aimed to investigate the association between dietary total and individual BCAAs intake and odds of general and abdominal obesity in a large group of adults. Methods: This cross-sectional study was conducted among 8691 adults aged 18-55 years in Isfahan, Iran. Dietary BCAAs were assessed using a validated dish-based 106-item semi-quantitative food frequency questionnaire (DS-FFQ). Information about weight and waist circumference were collected through a self-reported validated questionnaire. General obesity was de ned as body mass index (BMI) ≥30 kg/m 2 , and abdominal obesity was de ned as waist circumference (WC) ≥88 cm for women and ≥102 cm for men.Results: Mean age of study participants was 36.8±8.1 years. Prevalence of general obesity was 9.2% in men and 9.7% in women and that of abdominal obesity was 13.3% and 36.2% in men and women, respectively. We found that participants in the top tertile of total BCAAs intake had higher odds of general obesity compared with those in the bottom tertile (OR: 1.42; 95% CI: 1.09-1.84). Such signi cant association was seen in men (OR: 1.57; 95% CI: 1.05-2.34), but not in women (OR: 1.33; 95% CI: 0.94-1.89) in our strati ed analysis. We found no signi cant association between total BCAAs intake and odds of abdominal obesity. Strati ed by sex, no signi cant association was observed between total BCAAs intake and odds of abdominal obesity [

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Dietary intake of branched-chain amino acids in relation to general and abdominal obesity

et al. 2021

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“…The amino acid supplementation may have beneficial effects on the satiation signaling and energy intake [9], and the muscle metabolism supporting blood glucose control [10]. However, the impact of oral supplementation of BCAA in the modulation of metabolic risk seems to be influenced by the dietary environment exposure [116]. The potential health benefits have contributed to the popularity of these products.…”

Section: The Risks Of Unsupervised Protein and Amino Acid Supplemementioning

confidence: 99%

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

et al. 2019

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Sports nutrition products are developed and targeted mainly for athletes to improve their nutrient intake, performance, and muscle growth. The fastest growing consumer groups for these products are recreational sportspeople and lifestyle users. Although athletes may have elevated physiological protein requirements and they may benefit from dietary supplements, the evidence regarding the role of dietary protein and supplements in the nutrition of recreational sportspeople and sedentary populations is somewhat complex and contradictory. In high-protein diets, more undigested protein-derived constituents end up in the large intestine compared to moderate or low-protein diets, and hence, more bacterial amino acid metabolism takes place in the colon, having both positive and negative systemic and metabolic effects on the host. The aim of the present review is to summarize the impact of the high-protein products and diets on nutrition and health, in sportspeople and in sedentary consumers. We are opening the debate about the current protein intake recommendations, with an emphasis on evidence-based effects on intestinal microbiota and personalized guidelines regarding protein and amino acid supplementation in sportspeople and lifestyle consumers.

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“…Higher circulating BCAAs concentrations are associated with greater insulin resistance and type 2 diabetes [16,17]. With regard to Asian populations, however, a high BCAAs intake was found to reduce the risk of diabetes in a Japanese study [6], whereas higher BCAAs in a Chinese study [2] was related to higher risk of diabetes.…”

Section: Discussionmentioning

confidence: 95%

Independent and Opposite Associations Between Branched-Chain Amino Acids and Lysophosphatidylcholines With Incident Diabetes in Thais

et al. 2020

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Branched-chain amino acids (BCAAs) and lysophosphatidylcholines (LPCs) have been reported to be associated with diabetes. The purpose of the present study was to investigate the relative contributions of BCAAs and LPCs to the progression of prediabetes to diabetes using a targeted metabolomic approach. This study was part of a health survey of employees of the Electricity Generating Authority of Thailand (n = 79; nine females and 70 males). A targeted metabolomics analysis was performed using an AbsoluteIDQ® p180 kit, flow injection analysis, and liquid chromatography-tandem mass spectrometry. The highest variable importance in projection (VIP) scores for the progression to diabetes of the amino acids and phospholipids were associated with isoleucine and LPC acyl C28:1, respectively. Using logistic regression analysis, we found that high baseline isoleucine concentration was associated with a higher incidence of diabetes, while high LPC acyl 28:1 was associated with a lower incidence. Isoleucine and LPC acyl 28:1 were independently associated with incident diabetes in a model that also included conventional risk factors for diabetes (baseline fasting plasma glucose (FPG), age, sex, and body mass index (BMI)). In addition, isoleucine and LPC acyl 28:1 were independently associated with serum HbA1c 5 years later in a robust regression model that also included baseline FPG, age, sex, and BMI. Isoleucine, LPC acyl 28:1, age, and FPG were significantly associated with HbA1c at this time. In conclusion, these results provide evidence that isoleucine and LPC acyl C28:1 have respective positive and negative independent associations with incident diabetes.

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Dietary branched-chain amino acids intake exhibited a different relationship with type 2 diabetes and obesity risk: a meta-analysis

Cited by 34 publications

References 54 publications

Dietary intake of branched-chain amino acids in relation to general and abdominal obesity

Dietary intake of branched-chain amino acids in relation to general and abdominal obesity

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

Independent and Opposite Associations Between Branched-Chain Amino Acids and Lysophosphatidylcholines With Incident Diabetes in Thais

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