Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner

Hubbard, Troy D.; Murray, Iain A.; Nichols, Robert G.; Cassel, Kaitlyn; Podolsky, Michael A.; Kuzu, Guray; Tian, Yuan; Smith, Phillip D.; Kennett, Mary J.; Patterson, Andrew D.; Perdew, Gary H.

doi:10.1016/j.jff.2017.08.038

Cited by 71 publications

(75 citation statements)

References 60 publications

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“…There are several controversial findings about broccoli residues on gut flora. Hubbard et al (2017) reported that consumption of broccoli heightened intestinal aryl hydrocarbon receptor activity, decreased microbial abundance of the family Erysipelotrichaceae and attenuated colitis in mice. Pezeshkpour et al (2018) observed that broccoli extract inhibited the growth of standard and clinical Pseudomonas aeruginosa strains.…”

Section: Effect Of Broccoli Residues Fermented With Probiotics On Thementioning

confidence: 99%

Effect of Broccoli Residues Fermented with Probiotics on the Growth Performance and Health Status of Broilers Challenged with Clostridium Perfringens

Liu

Deng

Chen

et al. 2018

Braz. J. Poult. Sci.

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This study aimed at investigating the effects of broccoli residues fermented with probiotics (BF) on the growth performance, immunity, and gut health in broilers challenged with Clostridium perfringens (C. perfringens). A total of 600 broilers (one day old) were randomly allotted into five treatments with six replicates of 20 birds each and were reared until 42 days of age. The treatments included a positive control (PC, fed a basal diet and reared on uncontaminated litter), a negative control (NC, birds reared on litter contaminated with C. perfringens and fed a basal diet), and NC plus BF at 25, 50 or 75 g/kg of diet. The BF contained yeast 3.1 × 10 7 cfu/g, lactic acid bacteria 9.5 × 10 6 cfu/g and Bacillus subtilis 3.5 × 10 6 cfu/g. Birds in the NC group showed lower (p<0.05) feed intake and body weight gain, whereas BF supplementation recovered (p<0.05) the growth performance to the levels of PC group. Dietary BF at 50and 75 g/kg reduced (p<0.05) broiler mortality. Similarly, compared to the NC group, BF increased (p<0.05) immune organ weights and serum immunoglobulins A, G, and M to the levels of PC group. The ileal populations of Escherichia coli and Gram-negative bacteria were decreased (p<0.05) by BF to the levels of PC, and C. perfringens was also decreased (p<0.05) by BF. The serum profiles of mono-and di-amine oxidase were decreased (p<0.05) by BF. BF at 75 g/kg reduced (p<0.05) monoamine oxidase compared with the other BF doses. The results suggest that broccoli residues fermented with probiotics can be a novel biological feed additive to protect the performance and health of broilers against C. perfringens infection.

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Section: Effect Of Broccoli Residues Fermented With Probiotics On Thementioning

confidence: 99%

Effect of Broccoli Residues Fermented with Probiotics on the Growth Performance and Health Status of Broilers Challenged with Clostridium Perfringens

Liu

Deng

Chen

et al. 2018

Braz. J. Poult. Sci.

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“…Most of the current researches are focused on the content of secondary metabolites, mainly of glucosinolates. Many epidemiologic studies indicate that a high ingestion of brassicaceous vegetables is associated to a reduced risk of cancer [5,16], cardiovascular diseases [17], gut diseases (e.g., colite) [18], [19], and diabetes [20].…”

Section: Brassicas' Phytochemical Compositionmentioning

confidence: 99%

Agronomic Factors Influencing Brassica Productivity and Phytochemical Quality

Borges¹,

Seabra²,

Ponce³

et al. 2018

Brassica Germplasm - Characterization, Breeding and Utilization

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Agronomic practices and climatic factors affect the content and profile of phytochemicals. The effects of the environment, such as salinity, climate, and other abiotic factors, promote biochemical responses, inducing changes in the quantity and quality of polyphenol compounds, carotenoids, vitamins, glucosinolates, and polyamines, which are bioactive compounds. In plants, among the various functions, some phytochemicals can protect against biotic factors. Brassica vegetables are a source of several primary and secondary metabolism compounds, and they might be responsible for disease prevention. In addition, the increase of bioactive compounds in plant-based foods is important to the diet and consequently for the improvement of public health. In this chapter, we will point out the abiotic factors that affect the productive performance, quality, and chemical composition of different Brassica species and cultivars. We will also discuss its implications on plant protection and human health.

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“…Certain dietary compounds like polyphenols, mainly flavonoids, and tryptophan derivatives have been reported as AhR ligands . Recent studies showed the major significance of dietary compounds like tryptophan and phytochemicals like indole‐derivatives in both intestinal and microbial homeostasis in relation to AhR in mouse colitis models . As little is known about how metabolism of these compounds by microbes alters the AhR‐mediated signaling activity, we sought to study the kinetics of their release and the ability to activate the AhR using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME), simulating the ascending (AC), transverse (TC), and descending (DC) colon .…”

Section: Introductionmentioning

confidence: 99%

Polyphenols and Tryptophan Metabolites Activate the Aryl Hydrocarbon Receptor in an in vitro Model of Colonic Fermentation

Koper

Loonen

Wells

et al. 2018

Molecular Nutrition Food Res

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Scope Many dietary phytochemicals have been reported to promote gut health. Specific dietary phytochemicals, such as luteolin, as well as specific microbial metabolites of tryptophan are ligands of the aryl hydrocarbon receptor (AhR), which plays a role in immunity and homeostasis of the gut barrier. Here, the fate of luteolin during colonic fermentation and the contribution of tryptophan metabolites to AhR activity in different parts of the colon are investigated. Methods and results Several polyphenols are screened for AhR activation and oregano, containing the ligand luteolin, is added to batch cultures of human microbiota from the distal colon. Luteolin is rapidly metabolized, with no measurable increase in AhR activity. In the second experiment, using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME), not all luteolin is metabolized in the ascending colon, but disappear rapidly in the transverse colon. The greatest AhR activity is due to microbiota‐derived metabolites of tryptophan, particularly in the descending colon. Conclusions Luteolin in food is rapidly metabolized in the transverse colon. Tryptophan metabolism by the microbiota in the colon contributes substantially to the pool of lumen metabolites that can activate the AhR.

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Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner

Cited by 71 publications

References 60 publications

Effect of Broccoli Residues Fermented with Probiotics on the Growth Performance and Health Status of Broilers Challenged with Clostridium Perfringens

Effect of Broccoli Residues Fermented with Probiotics on the Growth Performance and Health Status of Broilers Challenged with Clostridium Perfringens

Agronomic Factors Influencing Brassica Productivity and Phytochemical Quality

Polyphenols and Tryptophan Metabolites Activate the Aryl Hydrocarbon Receptor in an in vitro Model of Colonic Fermentation

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